scholarly journals Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease

2017 ◽  
Vol 46 (1) ◽  
pp. 71-72 ◽  
Author(s):  
Kumar Sharma
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Amino Acids ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Myeloperoxidase Activity ◽  
Artery Disease

scholarly journals 83-Year-Old Man With Chronic Kidney Disease, Fluid Overload, and Coronary Artery Disease Develops Altered Mental Status

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. e111-e114 ◽  
Author(s):  
Brett C. Bade ◽  
Sean P. Callahan ◽  
Jean Paul Higuero ◽  
Nicholas Pastis ◽  
John Terrill Huggins
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Mental Status ◽  
Fluid Overload ◽  
Altered Mental Status ◽  
Artery Disease

Influence of chronic kidney disease on coronary plaque components in coronary artery disease patients with both diabetes mellitus and hypertension

2019 ◽  
Vol 34 (7) ◽  
pp. 1065-1075 ◽  
Author(s):  
Eiji Shigemoto ◽  
Atsushi Iwata ◽  
Makito Futami ◽  
Yuta Kato ◽  
Motoki Yamashita ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Coronary Plaque ◽  
Artery Disease

scholarly journals Improved Detection of Potentially Pleiotropic Genes in Coronary Artery Disease and Chronic Kidney Disease Using GWAS Summary Statistics

2020 ◽  
Vol 11 ◽  
Author(s):  
Haimiao Chen ◽  
Ting Wang ◽  
Jinna Yang ◽  
Shuiping Huang ◽  
Ping Zeng
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Association Studies ◽  
Functional Enrichment ◽  
Genome Wide Association Studies ◽  
Summary Statistics ◽  
Genetic Determination ◽  
Artery Disease

The coexistence of coronary artery disease (CAD) and chronic kidney disease (CKD) implies overlapped genetic foundation. However, the common genetic determination between the two diseases remains largely unknown. Relying on summary statistics publicly available from large scale genome-wide association studies (n = 184,305 for CAD and n = 567,460 for CKD), we observed significant positive genetic correlation between CAD and CKD (rg = 0.173, p = 0.024) via the linkage disequilibrium score regression. Next, we implemented gene-based association analysis for each disease through MAGMA (Multi-marker Analysis of GenoMic Annotation) and detected 763 and 827 genes associated with CAD or CKD (FDR < 0.05). Among those 72 genes were shared between the two diseases. Furthermore, by integrating the overlapped genetic information between CAD and CKD, we implemented two pleiotropy-informed informatics approaches including cFDR (conditional false discovery rate) and GPA (Genetic analysis incorporating Pleiotropy and Annotation), and identified 169 and 504 shared genes (FDR < 0.05), of which 121 genes were simultaneously discovered by cFDR and GPA. Importantly, we found 11 potentially new pleiotropic genes related to both CAD and CKD (i.e., ARHGEF19, RSG1, NDST2, CAMK2G, VCL, LRP10, RBM23, USP10, WNT9B, GOSR2, and RPRML). Five of the newly identified pleiotropic genes were further repeated via an additional dataset CAD available from UK Biobank. Our functional enrichment analysis showed that those pleiotropic genes were enriched in diverse relevant pathway processes including quaternary ammonium group transmembrane transporter, dopamine transport. Overall, this study identifies common genetic architectures overlapped between CAD and CKD and will help to advance understanding of the molecular mechanisms underlying the comorbidity of the two diseases.

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