scholarly journals Development of Auditory Evoked Responses in Normally Developing Preschool Children and Children with Autism Spectrum Disorder

2017 ◽  
Vol 39 (5) ◽  
pp. 430-441 ◽  
Author(s):  
Julia M. Stephen ◽  
Dina E. Hill ◽  
Amanda Peters ◽  
Lucinda Flynn ◽  
Tongsheng Zhang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Tone Burst ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Auditory Evoked Potential ◽  
Spectrum Disorder ◽  
Evoked Responses ◽  
Auditory Evoked Responses ◽  
Cortical Responses ◽  
The Mean

The cortical responses to auditory stimuli undergo rapid and dramatic changes during the first 3 years of life in normally developing (ND) children, with decreases in latency and changes in amplitude in the primary peaks. However, most previous studies have focused on children >3 years of age. The analysis of data from the early stages of development is challenging because the temporal pattern of the evoked responses changes with age (e.g., additional peaks emerge with increasing age) and peak latency decreases with age. This study used the topography of the auditory evoked magnetic field (AEF) to identify the auditory components in ND children between 6 and 68 months (n = 48). The latencies of the peaks in the AEF produced by a tone burst (ISI 2 ± 0.2 s) during sleep decreased with age, consistent with previous reports in awake children. The peak latencies of the AEFs in ND children and children with autism spectrum disorder (ASD) were compared. Previous studies indicate that the latencies of the initial components of the auditory evoked potential (AEP) and the AEF are delayed in children with ASD when compared to age-matched ND children >4 years of age. We speculated whether the AEF latencies decrease with age in children diagnosed with ASD as in ND children, but with uniformly longer latencies before the age of about 4 years. Contrary to this hypothesis, the peak latencies did not decrease with age in the ASD group (24-62 months, n = 16) during sleep (unlike in the age-matched controls), although the mean latencies were longer in the ASD group as in previous studies. These results are consistent with previous studies indicating delays in auditory latencies, and they indicate a different maturational pattern in ASD children and ND children. Longitudinal studies are needed to confirm whether the AEF latencies diverge with age, starting at around 3 years, in these 2 groups of children.

scholarly journals Delayed Auditory Evoked Responses in Autism Spectrum Disorder across the Life Span

2019 ◽  
Vol 41 (3-4) ◽  
pp. 223-233 ◽  
Author(s):  
Junko Matsuzaki ◽  
Matthew Ku ◽  
Marissa Dipiero ◽  
Taylor Chiang ◽  
Joni Saby ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Life Span ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Evoked Responses ◽  
Auditory Evoked Responses

Quality of life among parents of South African children with autism spectrum disorder

2018 ◽  
Vol 30 (4) ◽  
pp. 226-231 ◽  
Author(s):  
Ayman Alhazmi ◽  
Reneva Petersen ◽  
Kirsten A Donald
Keyword(s):  
Quality Of Life ◽  
Autism Spectrum Disorder ◽  
South African ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Life Assessment ◽  
Children With Asd ◽  
The Mean

AbstractObjectiveTo describe the quality of life (QOL) of South African parents caring for children with autism spectrum disorder (ASD) as compared with parents of typically developing (TD) children from the same community.MethodsA cross-sectional study was done evaluating the QOL of parents of 52 children (26 parents of children with ASD versus 26 parents of TD children) using a structured measure, (World Health Organization Quality of Life Assessment-BREF).ResultsThe mean age of the children with ASD was 64.9 months (SD 14.5) versus 60.1 months (SD 13.5) for TD group. There was a male predominance among group of children with ASD (48 boys, four girls). The mean parental age of the ASD group was 32.9 years (SD 7.8) compared with 33.8 years (SD 6.8) for the TD group. As compared with parents of the TD children, parents of children with ASD had lower mean QOL scores in the four QOL domains: physical, psychological, social and environmental health (p<0.0001). the domain where the discrepancy between groups was greatest was the physical domain Where the mean score was 52.1 (SD 18.7) in the ASD group and 92 (SD 10.4) in the TD group. Lower income, severity level of ASD and lack of access to school placement of children with ASD were found significantly associated with parents’ QOL domains.ConclusionQOL of parents of children with ASD is significant lower than that of the parents of their TD peers across all domains and is an important component in management of the family which needs to be explored and addressed.

scholarly journals Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Wilaiwan Sriwimol ◽  
Pornprot Limprasert
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Alpha Synuclein ◽  
Spectrum Disorder ◽  
Enzyme Linked Immunosorbent Assay ◽  
Not Otherwise Specified ◽  
The Mean ◽  
Presynaptic Proteins

Alpha-synuclein (α-synuclein) and beta-synuclein (β-synuclein) are presynaptic proteins playing important roles in neuronal plasticity and synaptic vesicle regulation. To evaluate the association of these two proteins and autism spectrum disorder (ASD), we investigated the plasma α-synuclein and β-synuclein levels in 39 male children with ASD (2 subgroups: 25 autism and 14 pervasive developmental disorder-not otherwise specified (PDD-NOS)) comparing with 29 sex- and age-matched controls by using enzyme-linked immunosorbent assay (ELISA). We first determined the levels of these two proteins in the ASD subgroups and found that there were no significant differences in both plasma α-synuclein and β-synuclein levels in the autism and PDD-NOS groups. Thus, we could combine the 2 subgroups into one ASD group. Interestingly, the mean plasma α-synuclein level was significantly lower (P<0.001) in the ASD children (10.82±6.46 ng/mL) than in the controls (29.47±18.62 ng/mL), while the mean plasma β-synuclein level in the ASD children (1344.19±160.26 ng/mL) was significantly higher (P<0.05) than in the controls (1219.16±177.10 ng/mL). This is the first study examining the associations between α-synuclein and β-synuclein and male ASD patients. We found that alterations in the plasma α-synuclein and β-synuclein levels might be implicated in the association between synaptic abnormalities and ASD pathogenesis.

scholarly journals Family support provided to children with autism spectrum disorder during COVID-19 pandemic: الدعم الأسري المقدم للأبناء ذوي اضطراب طيف التوحد في ظل جائحة COVID-19

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Suhair Mamdouh Al-Tal, Fuad Eid Al-Jawaldeh, Heyam Musa Al-T
Keyword(s):  
Autism Spectrum Disorder ◽  
Family Support ◽  
Economic Status ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Three Dimensions ◽  
Validity And Reliability ◽  
The Mean ◽  
The Impact

The study aimed to identify the level of family support provided to children with autism in light of the Covid 19 pandemic, and the Descriptive analytical method was adopted. To achieve the goals of this study, the researchers developed a tool that consisted of (29) items distributed into (3) dimensions (psychological, training, and recreational). The indications for the validity and reliability of this tool have been verified. The study sample included (86) mothers of children with autism spectrum disorder who were enrolled in special education centers for the year 2019/2020 in Amman, and the researchers reached many results, the most important of which are: The level of family support provided to children in light of the Covid 19 pandemic, according to their mothers' point of view, was average in the overall score of the Family Support Scale and in its three dimensions, where the mean of the total score was (3.34), and for the training dimension the mean was (3.51), while the recreational dimension was (3.41) and the psychological dimension was (3.12), the results indicated that there were no statistically significant differences at the level of significance (α = 0.05) in the level of family support provided to children with autism spectrum disorder in light of the Covid 19 pandemic according to the variables (economic status and educational qualification of mothers) and (age variable for children). The study recommended conducting more studies related to the impact of the Covid 19 pandemic on people with disabilities specifically for people with autism spectrum disorder, it also recommended to the relevant authorities the necessity to provide families and mothers of children with autism spectrum disorder with sufficient and necessary information about family support, its importance and the mechanism of its implementation

Instruction Using Augmentative and Alternative Communication Supports: Description of Current Practices by Speech-Language Pathologists Who Work With Children With Autism Spectrum Disorder

2020 ◽  
Vol 29 (2) ◽  
pp. 586-596 ◽  
Author(s):  
Kaitlyn A. Clarke ◽  
Diane L. Williams
Keyword(s):  
Autism Spectrum Disorder ◽  
Augmentative And Alternative Communication ◽  
Communication Systems ◽  
Diagnostic Category ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Alternative Communication ◽  
Speech Language Pathologists ◽  
Processing Differences

Purpose The aim of this research study was to examine common practices of speech-language pathologists (SLPs) who work with children with autism spectrum disorder (ASD) with respect to whether or not SLPs consider processing differences in ASD or the effects of input during their instruction. Method Following a qualitative research method, how SLPs instruct and present augmentative and alternative communication systems to individuals with ASD, their rationale for method selection, and their perception of the efficacy of selected interventions were probed. Semistructured interviews were conducted as part of an in-depth case report with content analysis. Results Based on completed interviews, 4 primary themes were identified: (a) instructional method , (b) input provided , (c) decision-making process , and (d) perceived efficacy of treatment . Additionally, one secondary theme, training and education received , was identified . Conclusions Clinicians reported making decisions based on the needs of the child; however, they also reported making decisions based on the diagnostic category that characterized the child (i.e., ASD). The use of modeling when teaching augmentative and alternative communication to individuals with ASD emerged as a theme, but variations in the method of modeling were noted. SLPs did not report regularly considering processing differences in ASD, nor did they consider the effects of input during instruction.

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