scholarly journals Role of Immune Cells in Acute Kidney Injury and Repair

Nephron ◽  
2017 ◽  
Vol 137 (4) ◽  
pp. 282-286 ◽  
Author(s):  
Sul A Lee ◽  
Sanjeev Noel ◽  
Mohanraj Sadasivam ◽  
Abdel R.A. Hamad ◽  
Hamid Rabb
Keyword(s):  
Acute Kidney Injury ◽  
Immune Cells ◽  
Kidney Injury ◽  
Injury And Repair

scholarly journals The Role of Myeloid Cells in Acute Kidney Injury and Kidney Repair

Kidney360 ◽  
2021 ◽  
Vol 2 (11) ◽  
pp. 1852-1864
Author(s):  
Leyuan Xu
Keyword(s):  
Acute Kidney Injury ◽  
Immune Responses ◽  
Immune Cells ◽  
Experimental Studies ◽  
Myeloid Cells ◽  
Kidney Injury ◽  
Adaptive Immune Responses ◽  
Injury Repair ◽  
Adaptive Immune

AKI remains highly prevalent, yet no optimal therapy is available to prevent it or promote recovery after initial insult. Experimental studies have demonstrated that both innate and adaptive immune responses play a central role during AKI. In response to injury, myeloid cells are first recruited and activated on the basis of specific signals from the damaged microenvironment. The subsequent recruitment and activation state of the immune cells depends on the stage of injury and recovery, reflecting a dynamic and diverse spectrum of immunophenotypes. In this review, we highlight our current understanding of the mechanisms by which myeloid cells contribute to injury, repair, and fibrosis after AKI.

A review of the role of immune cells in acute kidney injury

2017 ◽  
Vol 33 (10) ◽  
pp. 1629-1639 ◽  
Author(s):  
Anthony Bonavia ◽  
Kai Singbartl
Keyword(s):  
Acute Kidney Injury ◽  
Immune Cells ◽  
Kidney Injury

scholarly journals A zebrafish model of infection-associated acute kidney injury

2018 ◽  
Vol 315 (2) ◽  
pp. F291-F299 ◽  
Author(s):  
Xiaoyan Wen ◽  
Liyan Cui ◽  
Seth Morrisroe ◽  
Donald Maberry ◽  
David Emlet ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Unmet Need ◽  
Kidney Injury ◽  
Edwardsiella Tarda ◽  
Adult Zebrafish ◽  
Zebrafish Model ◽  
Pericardial Edema ◽  
Kidney Injury Molecule 1 ◽  
Dose Dependent

Sepsis-associated acute kidney injury (S-AKI) independently predicts mortality among critically ill patients. The role of innate immunity in this process is unclear, and there is an unmet need for S-AKI models to delineate the pathophysiological response. Mammals and zebrafish ( Danio rerio) share a conserved nephron structure and homologous innate immune systems, making the latter suitable for S-AKI research. We introduced Edwardsiella tarda to the zebrafish. Systemic E. tarda bacteremia resulted in sustained bacterial infection and dose-dependent mortality. A systemic immune reaction was characterized by increased mRNA expressions of il1b, tnfa, tgfb1a, and cxcl8-l1 ( P < 0.0001, P < 0.001, P < 0.001, and P < 0.01, respectively). Increase of host stress response genes ccnd1 and tp53 was observed at 24 h postinjection ( P < 0.0001 and P < 0.05, respectively). Moderate E. tarda infection induced zebrafish mortality of over 50% in larvae and 20% in adults, accompanied by pericardial edema in larvae and renal dysfunction in both larval and adult zebrafish. Expression of AKI markers insulin-like growth factor-binding protein-7 (IGFBP7), tissue inhibitor of metalloproteinases 2 (TIMP-2), and kidney injury molecule-1 (KIM-1) was found to be significantly increased in the septic animals at the transcription level ( P < 0.01, P < 0.05, and P < 0.05) and in nephric tubules compared with noninfected animals. In conclusion, we established a zebrafish model of S-AKI induced by E. tarda injection, with both larval and adult zebrafish showing nephron injury in the setting of infection.

Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy

2010 ◽  
Vol 43 (1) ◽  
pp. 237-240 ◽  
Author(s):  
Suhail Al-Salam ◽  
Ahmad Shaaban ◽  
Maha Alketbi ◽  
Naveed U. Haq ◽  
Samra Abouchacra
Keyword(s):  
Acute Kidney Injury ◽  
B Cell ◽  
Renal Biopsy ◽  
Cell Lymphoma ◽  
Kidney Injury ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Renoprotective effects of estrogen on acute kidney injury: the role of SIRT1

2021 ◽  
Author(s):  
Fatemeh Darvishzadeh Mahani ◽  
Mohammad Khaksari ◽  
Alireza Raji-amirhasani
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury

scholarly journals Autophagy in Acute Kidney Injury and Repair

2014 ◽  
Vol 127 (1-4) ◽  
pp. 56-60 ◽  
Author(s):  
Liyu He ◽  
Man J. Livingston ◽  
Zheng Dong
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Injury And Repair
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