scholarly journals Effect of Restriction of Foods with High Fructose Corn Syrup Content on Metabolic Indices and Fatty Liver in Obese Children

Obesity Facts ◽  
2017 ◽  
Vol 10 (4) ◽  
pp. 332-340 ◽  
Author(s):  
Lorena del Rocio Ibarra-Reynoso ◽  
Hilda Lissette López-Lemus ◽  
Ma Eugenia Garay-Sevilla ◽  
Juan Manuel Malacara
Keyword(s):  
Fatty Liver ◽  
High Fructose Corn Syrup ◽  
Obese Children ◽  
Corn Syrup ◽  
High Fructose ◽  
Metabolic Indices

scholarly journals The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases

2021 ◽  
Vol 22 (21) ◽  
pp. 12058
Author(s):  
Katsumi Iizuka
Keyword(s):  
Fatty Liver ◽  
Binding Protein ◽  
Carbohydrate Intake ◽  
Fibroblast Growth Factor 21 ◽  
High Fructose Corn Syrup ◽  
Response Element ◽  
Corn Syrup ◽  
High Fructose ◽  
Element Binding Protein ◽  
The Relationship

Carbohydrates are macronutrients that serve as energy sources. Many studies have shown that carbohydrate intake is nonlinearly associated with mortality. Moreover, high-fructose corn syrup (HFCS) consumption is positively associated with obesity, cardiovascular disease, and type 2 diabetes mellitus (T2DM). Accordingly, products with equal amounts of glucose and fructose have the worst effects on caloric intake, body weight gain, and glucose intolerance, suggesting that carbohydrate amount, kind, and form determine mortality. Understanding the role of carbohydrate response element binding protein (ChREBP) in glucose and lipid metabolism will be beneficial for elucidating the harmful effects of high-fructose corn syrup (HFCS), as this glucose-activated transcription factor regulates glycolytic and lipogenic gene expression. Glucose and fructose coordinately supply the metabolites necessary for ChREBP activation and de novo lipogenesis. Chrebp overexpression causes fatty liver and lower plasma glucose levels, and ChREBP deletion prevents obesity and fatty liver. Intestinal ChREBP regulates fructose absorption and catabolism, and adipose-specific Chrebp-knockout mice show insulin resistance. ChREBP also regulates the appetite for sweets by controlling fibroblast growth factor 21, which promotes energy expenditure. Thus, ChREBP partly mimics the effects of carbohydrate, especially HFCS. The relationship between carbohydrate intake and diseases partly resembles those between ChREBP activity and diseases.

Fructose and high fructose corn syrup: are they a two-edged sword?

2021 ◽  
pp. 1-23
Author(s):  
Nasim Khorshidian ◽  
Mahdi Shadnoush ◽  
Maryam Zabihzadeh Khajavi ◽  
Sara Sohrabvandi ◽  
Mojtaba Yousefi ◽  
...  
Keyword(s):  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
High Fructose
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