Prostate-Specific Antigen and Prostatic Acid Phosphatase in the Detection of Early Prostate Cancer and in the Prediction of Regional Lymph Node Métastasés

1992 ◽  
Vol 21 (4) ◽  
pp. 263-268 ◽  
Author(s):  
M.P. Wirth ◽  
H.G.W. Frohmüller
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Acid Phosphatase ◽  
Prostate Specific Antigen ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Specific Antigen ◽  
Prostatic Acid Phosphatase ◽  
Early Prostate Cancer ◽  
Node Metastases

Comparison of 11C-choline-PET/CT and whole body-MRI for staging of prostate cancer

2007 ◽  
Vol 46 (05) ◽  
pp. 161-168 ◽  
Author(s):  
A. C. Pfannenberg ◽  
A. Rieger ◽  
P. Aschoff ◽  
M. Müller ◽  
F. Paulsen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Bone Metastases ◽  
Lymph Node Metastases ◽  
Specific Antigen ◽  
Whole Body ◽  
Curative Therapy ◽  
Pet Ct ◽  
Node Metastases ◽  
Consensus Reading

SummaryAim of this study was to compare the diagnostic accuracy of positron emission tomography and computed tomography with 11C-Choline (Cho-PET/CT) and whole body magnetic resonance imaging (WB-MRI) for diagnostic work-up of prostate cancer. Patients, methods: We evaluated retrospectively 42 patients with untreated prostate cancer (n = 17), or increasing levels of prostate-specific antigen (PSA) after curative therapy (n = 25) who had been investigated by both Cho-PET/CT and WB-MRI. MRI, CT, and PET images were separately analyzed by experienced radiologists or nuclear medicine experts, followed by consensus reading. Validation was established by histology, follow-up, or consensus reading. Results: 88/103 detected lesions were considered as malignant: 44 bone metastases, 22 local tumor, 15 lymph node metastases, 3 lung, and 3 brain metastases. One further lesion was located in the adrenal gland, which was a second tumor. Overall sensitivity, specificity and accuracy for Cho-PET/CT were 96.6%, 76.5%, and 93.3%, resp., and for WB-MRI 78.4%, 94.1%, and 81.0%, resp. 3 vertebral metastases had initially been missed by Cho-PET/CT and were found retrospectively. MRI identified 2 bone metastases and 1 lymph node metastasis after being informed about the results of Cho-PET/CT. Conclusions: Cho-PET/CT and WB-MRI both presented high accuracy in the detection of bone and lymph node metastases. The strength of MRI is excellent image quality providing detailed anatomical information whereas the advantage of Cho-PET/CT is high image contrast of pathological foci.

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