The Impact of Prostate-Specific Antigen, Its Density and the Gleason Score in the Prediction of Extracapsular Disease in Prostate Carcinoma

1997 ◽  
Vol 31 (3) ◽  
pp. 311-316 ◽  
Author(s):  
Atif Akdaş ◽  
Tufan Tarcan ◽  
Levent Türkeri ◽  
Tuğrul Biren ◽  
Sevgi Küllü ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Prostate Carcinoma ◽  
Specific Antigen ◽  
The Impact

scholarly journals IMMUNOHISTOCHEMISTRY OF PROSTATE SPECIFIC ANTIGEN IN ADVANCED STAGE PROSTATE CARCINOMA. INMUNOHISTOQUÍMICA DEL ANTÍGENO PROSTÁTICO ESPECÍFICO EN ESTADÍOS AVANZADOS DEL CARCINOMA DE PRÓSTATA

2016 ◽  
Vol 2 (3) ◽  
pp. 106-111
Author(s):  
Elena V Bocan ◽  
Ovidiu Mederle ◽  
Marius Raica
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Gleason Score ◽  
Prostate Carcinoma ◽  
Perineural Invasion ◽  
Specific Antigen ◽  
Cell Hyperplasia ◽  
Prostate Hyperplasia ◽  
Cáncer De Próstata ◽  
Well Differentiated

El cáncer de próstata es la malignidad más frecuente en los seres humanos en la actualidad. Los estudios post mortem hacen una estimación que el carcinoma de próstata (PCa) se propagará en 25% de los hombres con enfermedad establecida histológica-mente. Material y método: Se ha hecho una investigación retrospectiva sobre la expresión inmune histoquímica de antígeno prostático específico (PSA) en 84 pacientes ingresados en el hospital con sospecha clínica de cáncer de próstata. Fueron examinadas portaobjetos del archivo de biopsia de resección transuretral, biopsia por punción con aguja hueca y cirugía abierta. Portaobjetos tenidos fueron utilizados para el diagnóstico patológico y para la puntuacion de Gleason. Portaobjetos adicionales fueron tenidos para antígeno prostático específico y la reacción final del producto fue estimado en negativo (0), bajo/moderado positivo (+1) y positivo intenso (+2). Resultados: Hiperplasia benigna próstata  fue encontrado en 14 casos, y todos mostraron una reacción moderada /intensa para el antígeno prostático específico. Hiperplasia asociada basal de células fue siempre negativa. Carcinoma fue encontrado en 68 pacientes. La reacción inmune para antígeno prostático específico fue positiva en 88.2% casos, y encontramos una relación directa entre la intensidad de la reacción y la puntuacion de Gleason. Todas las carcinomas uroteliales y pequeñas fueron negativas. La reacción PSA ha detectado 39.68 % de los casos con invasión perineural en comparación con solamente 23.8% encontrado en los portaobjetos tenidos hematoxilina-eosina (H&E). La expresión inmune antígeno prostático específico no discrimina entre lesiones benignas atípicas y el carcinoma  bien diferenciados. Conclusión: Se concluye que la reacción inmune antígeno prostático específico ayuda mucho para el diagnóstico diferenciado, detección de la invasión perineural, y el metástasis ganglionar.  Prostate cancer is the most frequent malignancy in human nowadays. Postmortem studies estimate that prostate carcinoma (PCa) will spread in only 25% of men with histologically defined disease. Material and method: It was retrospectively investigated the immunohistochemical expression of prostate-specific antigen (PSA) in 84 patients admitted with clinical suspicion of prostate cancer. Slides were performed from archive biopsies taken by transurethral resection, core biopsy and open surgery. Routine stained slides were used for the pathologic diagnosis and Gleason score. Additional slides were stained for PSA, and the final reaction product was estimated as negative (0), weak/moderate positive (+1), and intense positive (+2). Results: Benign prostate hyperplasia was found in 14 cases, and all showed moderate/intense reaction for PSA. Associated basal cell hyperplasia was always negative. Carcinoma was found in 68 patients. The immunoreaction for PSA was positive in 88.2% cases, and we found a direct relationship between the intensity of the reaction and Gleason score. All urothelial and small carcinomas were negative. PSA immunoreaction detected 39.68% cases with perineural invasion as compared with only 23.8% found on hematoxylin-eosin (H&E) stained slides. PSA immunoexpression does not discriminate between atypical benign lesions and well-differentiated carcinoma. Conclusion: It is concluded that PSA immunoreaction is helpful for the differential diagnosis, detection of the perineural invasion, and lymph node metastases. 

The impact of a delay in initiating radiation therapy on prostate-specific antigen outcome for patients with clinically localized prostate carcinoma

Cancer ◽  
2005 ◽  
Vol 103 (10) ◽  
pp. 2053-2059 ◽  
Author(s):  
Paul L. Nguyen ◽  
Richard Whittington ◽  
Sophia Koo ◽  
Delray Schultz ◽  
Kerri B. Cote ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Prostate Specific Antigen ◽  
Prostate Carcinoma ◽  
Specific Antigen ◽  
The Impact

scholarly journals Persistent Intraprostatic Androgen Concentrations after Medical Castration in Healthy Men

2006 ◽  
Vol 91 (10) ◽  
pp. 3850-3856 ◽  
Author(s):  
Stephanie T. Page ◽  
Daniel W. Lin ◽  
Elahe A. Mostaghel ◽  
David L. Hess ◽  
Lawrence D. True ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Transrectal Ultrasound ◽  
Receptor Expression ◽  
Prostate Cell ◽  
Hormone Levels ◽  
Prostate Biopsies ◽  
Clinical Consequences ◽  
Normal Men ◽  
The Impact

Abstract Context: The impact of serum androgen manipulation on prostate tissue hormone levels in normal men is unknown. Studies of men with prostate cancer have suggested that prostatic androgens are preserved in the setting of castration. Tissue androgens might stimulate prostate growth, producing adverse clinical consequences. Objective: The objective of the study was to determine the effect of serum androgen manipulation on intraprostatic androgens in normal men. Design: Thirteen male volunteers ages 35–55 yr (prostate-specific antigen < 2.0 ng/ml; normal transrectal ultrasound) were randomly assigned to: 1) a long-acting GnRH-antagonist, acyline, every 2 wk; 2) acyline plus testosterone (T) gel (10 mg/d); or 3) placebo for 28 d. Serum hormones were assessed weekly. Prostate biopsies were obtained on d 28. Extracted androgens were measured by RIA, and immunohistochemistry for androgen-regulated proteins was performed. Results: The mean decrease in serum T was 94%, whereas prostatic T and dihydrotestosterone levels were 70 and 80% lower, respectively, in subjects receiving acyline alone compared with controls (P < 0.05). Despite this decrease in prostate androgens, there were no detectable differences in prostate epithelial proliferation, apoptosis, prostate-specific antigen, and androgen receptor expression. Conclusion: In this small study of healthy subjects, despite a 94% decrease in serum T with medical castration, intraprostatic T and dihydrotestosterone levels remained 20–30% of control values, and prostate cell proliferation, apoptosis, and androgen-regulated protein expression were unaffected. Our data highlight the importance of assessing tissue hormone levels. The source of persistent prostate androgens associated with medical castration and their potential role in supporting prostate metabolism deserves further study.

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