Expression of Proliferating Cell Nuclear Antigen and Deoxyribonucleic Acid Value in Renal Cell Carcinoma: Correlation with Different Histopathological Parameters and Patient Survival

1996 ◽  
Vol 29 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Isteaq Ahmed Shameem ◽  
Tomoyuki Shimabukuro ◽  
Takashi Wada ◽  
Hiroaki Kurisu ◽  
Katsusuke Naito
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Deoxyribonucleic Acid ◽  
Patient Survival ◽  
Acid Value ◽  
Nuclear Antigen ◽  
Proliferating Cell

Proliferating Cell Nuclear Antigen: A New Prognostic Indicator in Renal Cell Carcinoma

1994 ◽  
Vol 152 (3) ◽  
pp. 834-836 ◽  
Author(s):  
K.J. Cronin ◽  
N.N. Williams ◽  
M.J. Kerin ◽  
T.A. Creagh ◽  
P.A. Dervan ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Indicator ◽  
Nuclear Antigen ◽  
Antigen A ◽  
Proliferating Cell

Relation to Pulmonary Metastasis of Alterations in p53 and Proliferating Cell Nuclear Antigen in Renal Cell Carcinoma

2000 ◽  
Vol 13 (2-3) ◽  
pp. 73-84
Author(s):  
Akinobu Gotoh ◽  
Toshiro Shirakawa ◽  
Keisuke Hanioka ◽  
Masato Fujisawa ◽  
Kazuo Gohji ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Pulmonary Metastasis ◽  
Renal Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferating Cell

The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma

2017 ◽  
Vol 68 (8) ◽  
pp. 1804-1806
Author(s):  
Daniela Anca Puscasiu ◽  
Gabriela Tanasie ◽  
Marius Georgescu ◽  
Romulus Fabian Tatu ◽  
Carmen Sofica Tatu
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Life Quality ◽  
Nuclear Antigen ◽  
Positive Expression ◽  
Immunohistochemical Techniques ◽  
Degree Of Differentiation ◽  
Proliferating Cell

The drive to prolong life and to improve life quality in patients suffering from cancer forms of any kind means that, aside from the necessary treatment, prognostic evaluations are needed. In our present study we included 63 patients with renal cell carcinoma. The histological samples obtained in surgery were studied through the classical histopathology methods, histochemical and immunohistochemical techniques. The histological degree of tumor differentiation was assessed for all cases, falling within all 4 classification grades. The immunohistochemical reaction for PCNA (proliferating cell nuclear antigen) was performed, utilizing the PC 10-LSAB antibody through visualization with the LSAB-DAB kit. This was the method used for assessing the process of tumor proliferation. Subsequently, the histological degree of differentiation was correlated with the PCNA score. We anticipate a reserved prognosis for patients with a positive expression on most tumor cells, which represents a high PCNA score.

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