Correlation between Bactericidal Activity of Fosfomycin Trometamol in an in vitro Model of the Urinary Bladder and Susceptibility Testing

1987 ◽  
Vol 13 (1) ◽  
pp. 80-85 ◽  
Author(s):  
C. Pinasi ◽  
E. Albini ◽  
G. Marca
Keyword(s):  
Urinary Bladder ◽  
Bactericidal Activity ◽  
In Vitro Model ◽  
Susceptibility Testing ◽  
Fosfomycin Trometamol ◽  
Vitro Model

Antibacterial Activity of Fosfomycin Trometamol in an in vitro Model of the Urinary Bladder

2015 ◽  
pp. 255-260 ◽  
Author(s):  
Giuseppe Cornaglia ◽  
Raffaello Pompei ◽  
Giovanni Foddis ◽  
Giuseppe Satta
Keyword(s):  
Antibacterial Activity ◽  
Urinary Bladder ◽  
In Vitro Model ◽  
Fosfomycin Trometamol ◽  
Vitro Model

An in vitro model of the urinary bladder

1978 ◽  
Vol 4 (2) ◽  
pp. 113-120 ◽  
Author(s):  
David Greenwood ◽  
Francis O'Grady
Keyword(s):  
Urinary Bladder ◽  
In Vitro Model ◽  
Vitro Model

scholarly journals Impact of sarA on Antibiotic Susceptibility of Staphylococcus aureus in a Catheter-Associated In Vitro Model of Biofilm Formation

2009 ◽  
Vol 53 (6) ◽  
pp. 2475-2482 ◽  
Author(s):  
Elizabeth C. Weiss ◽  
Horace J. Spencer ◽  
Sonja J. Daily ◽  
Brian D. Weiss ◽  
Mark S. Smeltzer
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Isolate ◽  
Antimicrobial Susceptibility ◽  
Antibiotic Susceptibility ◽  
Biofilm Formation ◽  
In Vitro Model ◽  
Susceptibility Testing ◽  
Specific Context ◽  
Vitro Model

ABSTRACT Mutation of the staphylococcal accessory regulator (sarA) in Staphylococcus aureus limits but does not abolish the capacity of the organism to form a biofilm. As a first step toward determining whether this limitation is therapeutically relevant, we carried out in vitro studies comparing the relative susceptibility of an S. aureus clinical isolate (UAMS-1) and its isogenic sarA mutant (UAMS-929) in the specific context of a catheter-associated biofilm. The antibiotics tested were daptomycin, linezolid, and vancomycin, all of which were evaluated by using concentrations based on the MIC defined as the breakpoint for a susceptible strain of S. aureus (≤1.0, ≤2.0, and ≤4.0 μg/ml for daptomycin, vancomycin, and linezolid, respectively). Mutation of sarA had no significant impact on the MIC of UAMS-1 for any of the targeted antibiotics, as defined by Etest antimicrobial susceptibility testing. However, mutation of sarA did result in a significant increase in antimicrobial susceptibility to all targeted antibiotics when they were tested in the specific context of a biofilm. Additionally, whether susceptibility was assessed by using UAMS-1 or its sarA mutant, daptomycin was found to be more effective against established S. aureus biofilms than either linezolid or vancomycin.

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