A Multimodal Imaging Guide to the Evaluation and Management of Neovascular Age-Related Macular Degeneration

2017 ◽  
pp. 14-31
Author(s):  
Sean T. Garrity ◽  
K. Bailey Freund ◽  
David Sarraf
Keyword(s):  
Macular Degeneration ◽  
Multimodal Imaging ◽  
Age Related Macular Degeneration ◽  
Age Related

Choroidal neovascular membranes secondary to intraocular tuberculosis misdiagnosed as neovascular age-related macular degeneration

2017 ◽  
Vol 28 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Alessandro Invernizzi ◽  
Aniruddha Agarwal ◽  
Maura Di Nicola ◽  
Fabio Franzetti ◽  
Giovanni Staurenghi ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Choroidal Neovascularization ◽  
Multimodal Imaging ◽  
Age Related Macular Degeneration ◽  
Enhanced Depth Imaging ◽  
Fundus Photography ◽  
Imaging Features ◽  
Neovascular Amd ◽  
Age Related ◽  
Intraocular Tuberculosis

Purpose: Intraocular tuberculosis (IOTB) can be complicated by choroidal neovascularization (CNV). However, when the CNV development is not accompanied by clear signs of inflammation, the etiology can be missed, especially in countries nonendemic for tuberculosis. We describe the clinical and imaging features of CNVs presenting as the first sign of IOTB initially misdiagnosed as exudative age-related macular degeneration (AMD). Methods: A retrospective review of clinical and imaging data of patients initially misdiagnosed with neovascular AMD later diagnosed with inflammatory CNV secondary to IOTB at tertiary referral centers was conducted. Features of fundus photography, fluorescein angiography, indocyanine green angiography, and enhanced depth imaging optical coherence tomography were analyzed. Distinguishing features between neovascular AMD and IOTB-associated CNV were evaluated. Results: Five patients over 55 years of age, erroneously diagnosed with exudative AMD, were included in the study. Multimodal imaging analysis allowed identification of peculiar choroidal alterations such as choroidal granulomas or choroiditis suggestive for posterior uveitis. Systemic workup for granulomatous uveitis including immunologic investigations such as tuberculin skin test or QuantiFERON TB Gold® and radiologic investigations revealed tubercular etiology in all the cases, allowing correct diagnosis and management of the uveitis and related CNV. Conclusions: Choroidal neovascularization represents a rare and unusual presenting sign of IOTB that can be misleading especially when it occurs in the elderly living in countries with low prevalence of the disease. Multimodal imaging can be helpful and should be employed, especially in atypical cases of CNV, in order to avoid misdiagnosis and/or diagnostic delays.

scholarly journals Multimodal imaging of dry age-related macular degeneration

2012 ◽  
Vol 90 (4) ◽  
pp. e281-e287 ◽  
Author(s):  
Raimondo Forte ◽  
Giuseppe Querques ◽  
Lea Querques ◽  
Nathalie Massamba ◽  
Valerie Le Tien ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Multimodal Imaging ◽  
Age Related Macular Degeneration ◽  
Age Related

Comparison of Exudative Age-related Macular Degeneration Subtypes in Japanese and French Patients: Multicenter Diagnosis With Multimodal Imaging

2014 ◽  
Vol 158 (2) ◽  
pp. 309-318.e2 ◽  
Author(s):  
Gabriel Coscas ◽  
Kenji Yamashiro ◽  
Florence Coscas ◽  
Umberto De Benedetto ◽  
Akitaka Tsujikawa ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Multimodal Imaging ◽  
Age Related Macular Degeneration ◽  
Age Related

PREVALENCE OF RETICULAR PSEUDODRUSEN IN AGE-RELATED MACULAR DEGENERATION USING MULTIMODAL IMAGING

Retina ◽  
2016 ◽  
Vol 36 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Flore De Bats ◽  
Thibaud Mathis ◽  
Martine Mauget-Faÿsse ◽  
Fabien Joubert ◽  
Philippe Denis ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Multimodal Imaging ◽  
Age Related Macular Degeneration ◽  
Reticular Pseudodrusen ◽  
Age Related

Bacillary layer detachment on optical coherence tomography in exudative age-related macular degeneration

2021 ◽  
pp. 112067212110640
Author(s):  
Ramesh Venkatesh ◽  
Nikitha G Reddy ◽  
Sameeksha Agrawal ◽  
Arpitha Pereira ◽  
Naresh Kumar Yadav ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Multimodal Imaging ◽  
Subretinal Fluid ◽  
Age Related Macular Degeneration ◽  
Intravitreal Injections ◽  
Optical Coherence ◽  
Photoreceptor Layer ◽  
Age Related ◽  
Subretinal Hyperreflective Material

Purpose To report the bacillary layer detachment on optical coherence tomography in exudative age-related macular degeneration. Methods Retrospective, observational cases Case descriptions Two cases of exudative age-related macular degeneration, one diagnosed as polypoidal choroidal vasculopathy following exudative age-related macular degeneration and other as wet age-related macular degeneration with choroidal neovascular membrane showed separation of myoid and ellipsoid zones of photoreceptor layer on optical coherence tomography. This is termed as BALAD. Other associated features noted were the presence of subretinal hyperreflective material, submacular hemorrhage and subretinal fluid. Both cases were treated with monthly intravitreal injections of Inj. Ranibizumab (0.5 mg/0.05 ml). Following 3 intravitreal injections at monthly intervals, reattachment of the bacillary layer detachment were noted in case 1 while the bacillary layer detachment persisted in case 2. Conclusion Multimodal imaging using optical coherence tomography in these cases revealed the separation of the bacillary layer following exudative age-related macular degeneration; a finding which is not routinely described in literature.

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