Preoperative Intra-Arterial Infusion Chemotherapy for Patients with Bladder Cancer

1989 ◽  
Vol 16 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Yoko Kubota ◽  
Hiroshi Kakizak ◽  
Kazuo Numasawa ◽  
Kiichi Suzuki ◽  
Hiroaki Kato
2001 ◽  
Vol 24 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Senji Hoshi ◽  
Ken-Ichi Suzuki ◽  
Ichiro Shintaku ◽  
Katsuko Sato ◽  
Yasuhiro Kaihou ◽  
...  

1983 ◽  
Vol 11 (S1) ◽  
Author(s):  
Shori Kanoh ◽  
Tomokazu Umeyama ◽  
Shinichi Nemoto ◽  
Satoru Ishikawa ◽  
Ryosuke Nemoto ◽  
...  

1997 ◽  
Vol 4 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Senji Hoshi ◽  
Hauping Mao ◽  
Toshiko Takahashi ◽  
Kenichi Suzuki ◽  
Masato Nose ◽  
...  

1987 ◽  
Vol 20 (S1) ◽  
Author(s):  
Hiroshi Kakizaki ◽  
Hitoshi Suzuki ◽  
Yoko Kubota ◽  
Kazuo Numasawa ◽  
Kiichi Suzuki

2018 ◽  
Vol 11 (2) ◽  
pp. 383-387
Author(s):  
Hiroshi Kano ◽  
Sotaro Miwa ◽  
Kiyoshi Koshida ◽  
Keiichi Kawai

We present a case in which neoadjuvant arterial infusion chemotherapy was effective in treating a large superficial bladder cancer. A 50-year-old male was admitted to the Kanazawa Medical Center with the complaint of dizziness. The patient exhibited severe anemia, and his computer tomography showed a large bladder tumor. Cystoscopy revealed a large papillary tumor. Magnetic resonance imaging showed no muscle invasion and no metastasis. To avoid a prolonged operation time and excessive blood loss, we performed neoadjuvant arterial infusion chemotherapy for tumor volume reduction before transurethral resection of the bladder tumor (TUR-BT). The arterial infusion chemotherapy was performed twice, and the tumor size gradually reduced from 275 to 28 cm3. After neoadjuvant chemotherapy, TUR-BT was safely performed without blood transfusion. The tumor was staged as T1 with G1. This is the first report demonstrating that neoadjuvant arterial infusion chemotherapy is effective in treating large superficial bladder cancer and is a possible strategy for bladder preservation.


Author(s):  
Qing Gou ◽  
Lingeng Wu ◽  
Wei Cui ◽  
Zhiqiang Mo ◽  
Dejin Zeng ◽  
...  

Abstract Objective To evaluate the efficacy and safety of stent placement combined with intraluminal radiofrequency ablation (intra-RFA) and hepatic arterial infusion chemotherapy (HAIC) for patients with advanced biliary tract cancers (Ad-BTCs) and biliary obstruction (BO). Methods We retrospectively reviewed data for patients with Ad-BTCs and BO who underwent stent placement with or without intra-RFA and HAIC in three centres between November 2013 and November 2018. The stent patency time (SPT), overall survival (OS), and adverse events (AEs) were analysed. Results Of the 135 enrolled patients, 64 underwent stent placement combined with intra-RFA and HAIC, while 71 underwent only stent placement. The median SPT was significantly longer in the combination group (8.2 months, 95% confidence interval [CI]: 7.1–9.3) than in the control group (4.3 months, 95% CI: 3.6–5.0; p < 0.001). A similar result was observed for OS (combination: 13.2 months, 95% CI: 11.1–16.5; control: 8.5 months, 95% CI: 7.6–9.6; p < 0.001). The incidence of AEs related to biliary tract operation was not significantly different between the two groups (p > 0.05). The most common AE and serious AE related to HAIC were alanine aminotransferase elevation (24/64; 37.5%) and thrombocytopenia (8/64; 12.5%), respectively. All AEs were tolerable, and there was no death from AEs. Conclusions Stent placement combined with intra-RFA and HAIC may be a safe, potential treatment strategy for patients with Ad-BTCs and BO. Key Points • Advanced biliary cancers (Ad-BTCs) with biliary obstruction (BO) can rapidly result in liver failure and cachexia with an extremely poor prognosis. • Stent placement combined with intraluminal radiofrequency ablation and hepatic arterial infusion chemotherapy may be safe and effective for patients with Ad-BTCs and BO. • The long-term efficacy and safety of the combined treatment is promising.


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