scholarly journals Multi-Infarct Dementia: A Historical Perspective

2017 ◽  
Vol 7 (1) ◽  
pp. 160-171 ◽  
Author(s):  
Erin McKay ◽  
Scott E. Counts
Keyword(s):  
Vascular Dementia ◽  
Historical Perspective ◽  
Original Description ◽  
Research Strategies ◽  
Research Technology ◽  
History Of ◽  
New Research

Background: Multi-infarct dementia (MID), a prominent subtype of vascular dementia (VaD), has only achieved recognition in the last 4 decades. Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. Summary: This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges. This paper follows the first descriptive decade, a shift to a preventative focus, a renewed interest coinciding with timely advances in research technology, and a hopeful return to treatment possibilities for VaD. Key Message: Concisely tracing the historical lineage of the modern understanding of MID, both as a singular entity and as part of the VaD con­stellation of disorders, provides a novel perspective on the foundation upon which future advances in combating vascular contributions to dementia will be based.

scholarly journals Defining research priorities in dystonia

Neurology ◽  
2020 ◽  
Vol 94 (12) ◽  
pp. 526-537 ◽  
Author(s):  
Codrin Lungu ◽  
Laurie Ozelius ◽  
David Standaert ◽  
Mark Hallett ◽  
Beth-Anne Sieber ◽  
...  
Keyword(s):  
Research Priorities ◽  
Large Data ◽  
Therapeutic Interventions ◽  
Research Progress ◽  
Data Sets ◽  
Cellular Mechanisms ◽  
Research Technology ◽  
Current State ◽  
History Of ◽  
New Research

ObjectiveDystonia is a complex movement disorder. Research progress has been difficult, particularly in developing widely effective therapies. This is a review of the current state of knowledge, research gaps, and proposed research priorities.MethodsThe NIH convened leaders in the field for a 2-day workshop. The participants addressed the natural history of the disease, the underlying etiology, the pathophysiology, relevant research technologies, research resources, and therapeutic approaches and attempted to prioritize dystonia research recommendations.ResultsThe heterogeneity of dystonia poses challenges to research and therapy development. Much can be learned from specific genetic subtypes, and the disorder can be conceptualized along clinical, etiology, and pathophysiology axes. Advances in research technology and pooled resources can accelerate progress. Although etiologically based therapies would be optimal, a focus on circuit abnormalities can provide a convergent common target for symptomatic therapies across dystonia subtypes. The discussions have been integrated into a comprehensive review of all aspects of dystonia.ConclusionOverall research priorities include the generation and integration of high-quality phenotypic and genotypic data, reproducing key features in cellular and animal models, both of basic cellular mechanisms and phenotypes, leveraging new research technologies, and targeting circuit-level dysfunction with therapeutic interventions. Collaboration is necessary both for collection of large data sets and integration of different research methods.

Competing Research Traditions in American Industry: Uncertain Alliances between Engineering and Science at Westinghouse Electric, 1886–1935

2005 ◽  
Vol 6 (4) ◽  
pp. 601-645 ◽  
Author(s):  
Ronald R. Kline ◽  
Thomas C. Lassman
Keyword(s):  
World War Ii ◽  
Materials Testing ◽  
American Industry ◽  
Research Strategies ◽  
Engineering Research ◽  
History Of ◽  
Fundamental Research ◽  
Set Up ◽  
Westinghouse Electric ◽  
New Research

Westinghouse Electric opened a new research laboratory near the company’s main factory in East Pittsburgh, Pennsylvania, in 1916. Located in the suburban borough of Forest Hills, the laboratory was set up to provide scientific knowledge for the older materials testing and product development laboratories at the factory. Unlike its industrial counterparts, however, the Forest Hills laboratory was dominated by a strong engineering research tradition that disrupted efforts undertaken in the 1920s and again in the 1930s to build and sustain a diversified fundamental research program. Whereas Eastman Kodak, DuPont, AT&T, and General Electric had successfully integrated fundamental research into their corporate laboratories, the Forest Hills laboratory remained the site of recurring tensions between two cultures of innovation—one based on fundamental science, the other on engineering research. Although such tensions often resulted in competing research strategies, managerial conflicts, and mismatched corporate priorities, the long-standing culture of engineering research contributed far more to Westinghouse’s strategic growth than even the most advanced fundamental research. More generally, the interactions between the cultures of engineering and science that characterize the early history of industrial research at Westinghouse highlight the evolving and sometimes conflicting patterns of technological innovation and organizational change in American industry before World War II.

Economic Views of L. Trotsky

2004 ◽  
pp. 142-157
Author(s):  
M. Voeikov ◽  
S. Dzarasov
Keyword(s):  
Civil War ◽  
20Th Century ◽  
Significant Role ◽  
Historical Perspective ◽  
Russian Revolution ◽  
Russian History ◽  
History Of

The paper written in the light of 125th birth anniversary of L. Trotsky analyzes the life and ideas of one of the most prominent figures in the Russian history of the 20th century. He was one of the leaders of the Russian revolution in its Bolshevik period, worked with V. Lenin and played a significant role in the Civil War. Rejected by the party bureaucracy L. Trotsky led uncompromising struggle against Stalinism, defending his own understanding of the revolutionary ideals. The authors try to explain these events in historical perspective, avoiding biases of both Stalinism and anticommunism.

‘The Stuff of Slow Constitution’: Reading Down Syndrome for Race, Disability, and the Timing that Makes Them So

Somatechnics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 235-248 ◽  
Author(s):  
Mel Y. Chen
Keyword(s):  
Down Syndrome ◽  
Trisomy 21 ◽  
Historical Perspective ◽  
Early History ◽  
Present Moment ◽  
History Of ◽  
Living Being

In this paper I would like to bring into historical perspective the interrelation of several notions such as race and disability, which at the present moment seem to risk, especially in the fixing language of diversity, being institutionalised as orthogonal in nature to one another rather than co-constitutive. I bring these notions into historical clarity primarily through the early history of what is today known as Down Syndrome or Trisomy 21, but in 1866 was given the name ‘mongoloid idiocy’ by English physician John Langdon Down. In order to examine the complexity of these notions, I explore the idea of ‘slow’ populations in development, the idea of a material(ist) constitution of a living being, the ‘fit’ or aptness of environmental biochemistries broadly construed, and, finally, the germinal interarticulation of race and disability – an ensemble that continues to commutatively enflesh each of these notions in their turn.

FBI and Religion

2017 ◽  
Keyword(s):  
Religious Orientation ◽  
Religious Communities ◽  
Academic Scholarship ◽  
History Of ◽  
Interdisciplinary Assessment ◽  
Civic Religion ◽  
New Research ◽  
The Relationship ◽  
The Way

This volume is an interdisciplinary assessment of the relationship between religion and the FBI. We recount the history of the FBI’s engagement with multiple religious communities and with aspects of public or “civic” religion such as morality and respectability. The book presents new research to explain roughly the history of the FBI’s interaction with religion over approximately one century, from the pre-Hoover period to the post-9/11 era. Along the way, the book explores vexed issues that go beyond the particulars of the FBI’s history—the juxtaposition of “religion” and “cult,” the ways in which race can shape the public’s perceptions of religion (and vica versa), the challenges of mediating between a religious orientation and a secular one, and the role and limits of academic scholarship as a way of addressing the differing worldviews of the FBI and some of the religious communities it encounters.

THE FIRST WISCONSIN ACCOUNTANCY BILL: AN HISTORICAL PERSPECTIVE

1998 ◽  
Vol 25 (2) ◽  
pp. 113-128
Author(s):  
Joann Noe Cross
Keyword(s):  
Historical Perspective ◽  
Documentary History ◽  
History Of ◽  
La Follette

Wisconsin's first attempt to pass legislation certifying accountants occurred in 1901, the beginning of the La Follette era. Overwhelmed by the issues of the day, this first bill died and another was not introduced until the incorporation of the Wisconsin Association of Accountants in 1905. Subsequent legislation failed to pass each year until 1913 when a bill was finally signed by Governor Francis McGovern. The details of these efforts hint at political rivalries and professional dedication. This paper attempts to relate not only the documentary history of these bills, but also to convey a sense of the underlying debates.

Clause Structure and Word Order in the History of German

2018 ◽  
Keyword(s):  
Word Order ◽  
Left Periphery ◽  
Structural Factors ◽  
Clause Structure ◽  
Verb Second ◽  
Verb Forms ◽  
History Of ◽  
New Research ◽  
The Right ◽  
Theoretical Analyses

Over roughly the last decade, there has been a notable rise in new research on historical German syntax in a generative perspective. This volume presents a state-of-the-art survey of this thriving new line of research by leading scholars in the field, combining it with new insights into the syntax of historical German. It is the first comprehensive and concise generative historical syntax of German covering numerous central aspects of clause structure and word order, tracing them throughout various historical stages. Each chapter combines a solid empirical basis and valid descriptive generalizations with reference also to the more traditional topological model of the German clause with a detailed discussion of theoretical analyses couched in the generative framework. The volume is divided into three parts according to the main parts of the clause: the left periphery dealing with verbal placement and the filling of the prefield (verb second, verb first, verb third orders) as well as adverbial connectives; the middle field including discussion of pronominal syntax, order of full NPs and the history of negation; and the right periphery with chapters on basic word order (OV/VO), prosodic and information-structural factors, and the verbal complex including the development of periphrastic verb forms and the phenomena of IPP (infinitivus pro participio) and ACI (accusativus cum infinitivo). This book thus provides a convenient overview of current research on the major issues concerning historical German clause structure both for scholars interested in more traditional description and for those interested in formal accounts of diachronic syntax.

scholarly journals Medical Education From a Theory–Practice–Philosophy Perspective

2021 ◽  
Vol 8 ◽  
pp. 237428952110102
Author(s):  
Susan A. Kirch ◽  
Moshe J. Sadofsky
Keyword(s):  
United States ◽  
Medical Education ◽  
Curriculum Design ◽  
Historical Perspective ◽  
Curriculum And Instruction ◽  
Medical Curriculum ◽  
Educational Theory ◽  
The United States ◽  
History Of ◽  
How People Learn

Medical schooling, at least as structured in the United States and Canada, is commonly assembled intuitively or empirically to meet concrete goals. Despite a long history of scholarship in educational theory to address how people learn, this is rarely examined during medical curriculum design. We provide a historical perspective on educational theory–practice–philosophy and a tool to aid faculty in learning how to identify and use theory–practice–philosophy for the design of curriculum and instruction.

scholarly journals Ernst von Leyden (1832–1910): a pioneer in making oncology a respected medical discipline

2021 ◽  
Author(s):  
Peter Voswinckel ◽  
Nils Hansson
Keyword(s):  
International Association ◽  
German Society ◽  
Scientific Discipline ◽  
Strong Impact ◽  
Medical Discipline ◽  
History Of ◽  
National Socialists ◽  
New Research ◽  
German Physician

Abstract Purpose This article presents new research on the role of the renowned German physician Ernst von Leyden (1832–1910) in the emergence of oncology as a scientific discipline. Methods The article draws on archival sources from the archive of the German Society of Haematology and primary and secondary literature. Results Leyden initiated two important events in the early history of oncology: the first international cancer conference, which took place in Heidelberg, Germany, in 1906, and the founding of the first international association for cancer research (forerunner of today's UICC) in Berlin in 1908. Unfortunately, these facts are not mentioned in the most recent accounts. Both had a strong impact on the professionalization of oncology as a discipline in its own right. Conclusion Although not of Jewish origin, von Leyden was considered by the National Socialists to be “Jewish tainted”, which had a lasting effect on his perception at home and abroad.

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