Increased Right Ventricular Wall Thickness in Hypertrophic Cardiomyopathy

1988 ◽  
Vol 2 (3) ◽  
pp. 134-139 ◽  
Author(s):  
J. Candell-Riera ◽  
A. Alvarez-Auñón ◽  
F. Balda-Caravedo ◽  
H. Garcia-del-Castillo ◽  
G. Permanyer-Miralda ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Right Ventricular ◽  
Wall Thickness ◽  
Ventricular Wall ◽  
Right Ventricular Wall ◽  
Ventricular Wall Thickness

The Prevalence and Long-Term Outcomes of Extreme Right versus Extreme Left Ventricular Hypertrophic Cardiomyopathy

Cardiology ◽  
2015 ◽  
Vol 133 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Xiying Guo ◽  
Chaomei Fan ◽  
Hongyue Wang ◽  
Shihua Zhao ◽  
Fujian Duan ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Right Ventricular ◽  
Wall Thickness ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Ventricular Wall ◽  
Extreme Right ◽  
Mortality And Morbidity ◽  
Right Ventricular Wall ◽  
Ventricular Wall Thickness

Objectives: Extreme left ventricular hypertrophy (LVH) is a known risk factor for sudden cardiac death in hypertrophic cardiomyopathy (HCM). Extreme right ventricular hypertrophy (RVH) is rare, and whether it is linked to a poor outcome is unknown. This study was designed to investigate differences between HCM patients with extreme RVH and those with extreme LVH. Methods: Among 2,413 HCM patients, 31 with extreme RVH (maximum right ventricular wall thickness ≥10 mm) and 194 with extreme LVH (maximum left ventricular wall thickness ≥30 mm) were investigated. The main clinical features and natural history were compared between the 2 groups. Results: The prevalence of extreme RVH and extreme LVH was 1.3 and 8.0%, respectively. Patients with extreme RVH tended to be younger and female (p < 0.01). Cardiovascular-related mortality and morbidity within 10 years were significantly greater in the extreme RVH group (p < 0.05). Multivariate analysis demonstrated 3 independent predictors for cardiovascular mortality - extreme RVH, left ventricular end-diastolic dimension ≥50 mm, and age ≤18 years at baseline - and 2 for morbidity - extreme RVH and presyncope. Conclusions: Compared with extreme LVH, extreme RVH was quite uncommon in HCM and had a worse prognosis. A right ventricle examination should be performed in routine HCM evaluation.

Inferior Right Ventricular Wall Thickness by Echocardiogram: A Novel Method of Assessing Hypertrophy in Neonates and Infants

2020 ◽  
Vol 41 (8) ◽  
pp. 1617-1622
Author(s):  
Harrison D. Pravder ◽  
Emina Hodzic ◽  
Puneet Bhatla ◽  
Melissa Busovsky-McNeal ◽  
James C. Nielsen
Keyword(s):  
Right Ventricular ◽  
Wall Thickness ◽  
Ventricular Wall ◽  
Right Ventricular Wall ◽  
Ventricular Wall Thickness ◽  
Novel Method ◽  
Neonates And Infants

scholarly journals Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension The first two authors contributed equally to this manuscript.

2020 ◽  
Vol 10 (2) ◽  
pp. 204589402091097
Author(s):  
Fotios Spyropoulos ◽  
Sally H. Vitali ◽  
Marlin Touma ◽  
Chase D. Rose ◽  
Carter R. Petty ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Wall Thickness ◽  
Ventricular Wall ◽  
Right Ventricular Systolic Pressure ◽  
Acceleration Time ◽  
Non Invasive ◽  
Right Ventricular Wall ◽  
Ventricular Wall Thickness ◽  
Pulmonary Arterial

Echocardiography is the gold standard non-invasive technique to diagnose pulmonary hypertension. It is also an important modality used to monitor disease progression and response to treatment in patients with pulmonary hypertension. Surprisingly, only few studies have been conducted to validate and standardize echocardiographic parameters in experimental animal models of pulmonary hypertension. We sought to define cut-off values for both invasive and non-invasive measures of pulmonary hemodynamics and right ventricular hypertrophy that would reliably diagnose pulmonary hypertension in three different rat models. The study was designed in two phases: (1) a derivation phase to establish the cut-off values for invasive measures of right ventricular systolic pressure, Fulton's index (right ventricular weight/left ventricle + septum weight), right ventricular to body weight ratio, and non-invasive echocardiographic measures of pulmonary arterial acceleration time, pulmonary arterial acceleration time to ejection time ratio and right ventricular wall thickness in diastole in the hypoxic and monocrotaline rat models of pulmonary hypertension and (2) a validation phase to test the performance of the cut-off values in predicting pulmonary hypertension in an independent cohort of rats with Sugen/hypoxia-induced pulmonary hypertension. Our study demonstrates that right ventricular systolic pressure ≥35.5 mmHg and Fulton's Index ≥0.34 are highly sensitive (>94%) and specific (>91%) cut-offs to distinguish animals with pulmonary hypertension from controls. When pulmonary arterial acceleration time/ejection time and right ventricular wall thickness in diastole were both measured, a result of either pulmonary arterial acceleration time/ejection time ≤0.25 or right ventricular wall thickness in diastole ≥1.03 mm detected right ventricular systolic pressure ≥35.5 mmHg or Fulton's Index ≥0.34 with a sensitivity of 88% and specificity of 100%. With properly validated non-invasive echocardiography measures of right ventricular performance in rats that accurately predict invasive measures of pulmonary hemodynamics, future studies can now utilize these markers to test the efficacy of different treatments with preclinical therapeutic modeling.

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