Left Ventricular Blood Flow Patterns Assessed by Magnetic Resonance Velocity Mapping in Patients with Ischemic Heart Disease

1994 ◽  
Vol 8 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Kim Houlind ◽  
Erik M. Pedersen ◽  
Sten Oyre ◽  
W. Yong Kim ◽  
Peter Walker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Magnetic Resonance ◽  
Ischemic Heart Disease ◽  
Flow Patterns ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Velocity Mapping ◽  
Blood Flow Patterns ◽  
Magnetic Resonance Velocity Mapping

The function of the aorta in ischemic heart disease: A magnetic resonance and angiographic study of aortic compliance and blood flow patterns

1989 ◽  
Vol 118 (2) ◽  
pp. 234-247 ◽  
Author(s):  
Hugo G. Bogren ◽  
Raad H. Mohiaddin ◽  
Richard K. Klipstein ◽  
David N. Firmin ◽  
Richard S. Underwood ◽  
...  
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Magnetic Resonance ◽  
Ischemic Heart Disease ◽  
Flow Patterns ◽  
Ischemic Heart ◽  
Aortic Compliance ◽  
Angiographic Study ◽  
Blood Flow Patterns

Morphology of Coronary Arteries in relation to Ischemic Heart Disease

2021 ◽  
Vol 27 ◽  
Author(s):  
Aurelio Leone
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Coronary Arteries ◽  
Coronary Circulation ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Ventricular Wall ◽  
The Right

Background: Background. The anatomical features of the coronary circulation show some interesting data which have been obtained by both in vivo and postmortem studies. Methods: This editorial describes the morphology and main alterations of coronary arteries, which supply blood flow to heart muscle, observed in the ischemic heart disease. Results : The great majority of myocardial muscle is under the control of the left coronary arteries: the left main coronary artery and its branches, the left anterior descending artery, and circumflex artery, which provide several arterial vessels particularly to the left anterior ventricular wall, interventricular septum and apex of the heart. Therefore, a large portion of the posterior left ventricular wall is supplied by left coronary circulation. The right coronary artery supplies blood flow to the posterior wall of the heart and the right atrium. Coronary anastomoses have been demonstrated into the myocardium showing that coronary arteries widely communicate among themselves. The main lesions of the coronary tree in subjects suffering from ischemic heart disease are related to coronary atherosclerosis. Conclusion: Morphology of coronary arteries is strongly influenced by ischemic pathology of the heart.

scholarly journals FEATURES OF MICROCIRCULATORY DYSFUNCTION ACCORDING TO WAVLET ANALYSIS LASER DOPPLER FLOWMETRY IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE AND CONCOMITANT DIFFUSE LIVER DISEASES

2020 ◽  
pp. 16-29
Author(s):  
S. Mostovyi ◽  
O. Dynnyk ◽  
N. Marunchyn
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Wavelet Analysis ◽  
Ischemic Heart Disease ◽  
Laser Doppler Flowmetry ◽  
Left Ventricular ◽  
Laser Doppler ◽  
Ischemic Heart ◽  
Doppler Flowmetry ◽  
Microcirculatory Dysfunction

Aim. To determine the features of microcirculatory dysfunction and in patients with chronic ischemic heart disease, depending on the presence of concomitant diffuse liver disease. Materials and methods. We performed a prospective study on the basis of MC «Doctor Vera», as well as in the diagnostic department of Medbud Clinic between 2009 and 2019. A total of 187 patients were examined. Patients' blood flow was assessed by transthoracic echocardiography, wavelet analysis laser Doppler flowmetry (LDF). Results. In the analysis of indicators of microcirculatory dysfunction in patients with ischemic heart disease, statistically significant deterioration of wavelet analysis laser Doppler flowmetry was determined. In patients with ischemic heart disease and left ventricular ejection fraction < 40 %, indicators of wavelet analysis LDF were significantly lower. We also found that the severity of diffuse liver disease significantly disrupts peripheral blood flow (Р < 0.05). Conclusions. The results of intracardiac hemodynamics, microcirculatory dysfunction were first presented. In patients with isolated ischemic heart disease as the left ventricular EF decreased, a significant decrease in capillary blood flow was observed as a result of deterioration of central hemodynamics, development of atherosclerotic vascular changes, as well as an increase in their vascular tone. We have proved that in the presence of DLD in patients with ischemic heart disease and EF < 40 %, the degree of increase in peripheral resistance and impaired venous outflow were more pronounced due to the depletion of vasoactive substances production, impaired their excretion by hepatocytes due to irreversible morpho-functional changes in liver at the stage of decompensation of HF, severe fibrosis, the formation of regeneration nodes. In patients with LC, the most severe disorders of peripheral blood flow were determined according to the data of the digital capillaroscopy, which testifies to the influence of the degree of liver damage on the state of microcirculation.

Glutamine Is Cardioprotective in Patients with Ischemic Heart Disease following Cardiopulmonary Bypass

2011 ◽  
Vol 14 (6) ◽  
pp. 384 ◽  
Author(s):  
Vladimir V. Lomivorotov ◽  
Sergey M. Efremov ◽  
Vladimir A. Shmirev ◽  
Dmitry N. Ponomarev ◽  
Vladimir N. Lomivorotov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Placebo Group ◽  
Cardiopulmonary Bypass ◽  
Ischemic Heart Disease ◽  
Troponin I ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Ejection ◽  
Study Group ◽  
Cardioprotective Effects

<p><b>Background:</b> The aim of the present study was to investigate the cardioprotective effects of the perioperative use of N(2)-L-alanyl-L-glutamine (GLN) in patients with ischemic heart disease (IHD) who undergo their operations under cardiopulmonary bypass (CPB).</p><p><b>Methods:</b> This double-blind, placebo-controlled, randomized study included 50 patients who underwent cardiac surgery with CPB. Exclusion criteria were a left ventricular ejection fraction <50%, diabetes mellitus, <3 months since the onset of myocardial infarction, and emergency surgery. Patients in the study group (n = 25) received 0.4 g/kg GLN (Dipeptiven, 20% solution) per day. Patients in the control group (n = 25) were administered a placebo (0.9% NaCl). The primary end point was the dynamics of troponin I at the following stages: (1) prior to anesthesia, (2) 30 minutes after CPB, (3) 6 hours after CPB, (4) 24 hours after surgery, and (5) 48 hours after surgery. Secondary end points included measurements of hemodynamics with a Swan-Ganz catheter.</p><p><b>Results:</b> On the first postoperative day after the surgery, the median troponin I level was significantly lower in the study group than in the placebo group: 1.280 ng/mL (interquartile range [IQR], 0.840-2.230 ng/mL) versus 2.410 ng/mL (IQR, 1.060-6.600 ng/mL) (<i>P</i> = .035). At 4 hours after cardiopulmonary bypass (CPB), the median cardiac index was higher in the patients in the study group: 2.58 L/min per m<sup>2</sup> (IQR, 2.34-2.91 L/min per m<sup>2</sup>) versus 2.03 L/min per m<sup>2</sup> (IQR, 1.76-2.32 L/min per m<sup>2</sup>) (<i>P</i> = .002). The median stroke index also was higher in the patients who received GLN: 32.8 mL/m<sup>2</sup> (IQR, 27.8-36.0 mL/m<sup>2</sup>) versus 26.1 mL/m<sup>2</sup> (IQR, 22.6-31.8 mL/m<sup>2</sup>) (<i>P</i> = .023). The median systemic vascular resistance index was significantly lower in the study group than in the placebo group: 1942 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 1828-2209 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) versus 2456 dyn�s/cm<sup>5</sup> per m<sup>2</sup> (IQR, 2400-3265 dyn�s/cm<sup>5</sup> per m<sup>2</sup>) (<i>P</i> = .001).</p><p><b>Conclusion:</b> Perioperative administration of GLN during the first 24 hours has cardioprotective effects in IHD patients following CPB. This technique enhances the troponin concentration at 24 hours after surgery and is associated with improved myocardial function.</p>

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