Dexamethasone and Glucagon Cause Synergistic Increases of Urea Cycle Enzyme Activities in Livers of Normal But Not Adrenalectomized Rats

Enzyme ◽  
1991 ◽  
Vol 45 (1-2) ◽  
pp. 30-38 ◽  
Author(s):  
Philip J. Snodgrass
Keyword(s):  
Enzyme Activities ◽  
Urea Cycle ◽  
Cycle Enzyme ◽  
Urea Cycle Enzyme ◽  
Adrenalectomized Rats

Urea Cycle Enzyme Activities of Liver of the African Lion

Nature ◽  
1966 ◽  
Vol 210 (5043) ◽  
pp. 1367-1367 ◽  
Author(s):  
G. W. BROWN
Keyword(s):  
Enzyme Activities ◽  
Urea Cycle ◽  
Cycle Enzyme ◽  
African Lion ◽  
Urea Cycle Enzyme

Influence of feeding increasing levels of dry or modified wet corn distillers’ grains plus solubles in whole corn grain-based finishing diets on hepatic and renal mass, and glutathione peroxidase and urea cycle enzyme activities in finishing cattle

2015 ◽  
Vol 95 (3) ◽  
pp. 407-415 ◽  
Author(s):  
H. Salim ◽  
K. M. Wood ◽  
J. P. Cant ◽  
K. C. Swanson
Keyword(s):  
Glutathione Peroxidase ◽  
Enzyme Activities ◽  
Urea Cycle ◽  
Distillers Grains ◽  
Synthetase Activity ◽  
Cycle Enzyme ◽  
Finishing Diets ◽  
Corn Distillers ◽  
Urea Cycle Enzyme ◽  
Corn Grain

Salim, H., Wood, K. M., Cant, J. P. and Swanson, K. C. 2015. Influence of feeding increasing levels of dry or modified wet corn distillers’ grains plus solubles in whole corn grain-based finishing diets on hepatic and renal mass, and glutathione peroxidase and urea cycle enzyme activities in finishing cattle. Can. J. Anim. Sci. 95: 407–415. Forty-two cross-bred steers (BW=357±5.8 kg) fed whole corn grain-based finishing diets were used in a completely randomized block (60, 120, or 180 d on feed) design (2×3 factorial arrangement of treatments plus control) to determine the effect of inclusion level [0 (control), 16.7, 33.3, and 50% of diet DM) and form (dry (DDGS) or modified wet (MWDGS)] of distillers’ grains plus solubles (DGS) on hepatic and renal glutathione peroxidase (GPx) and hepatic urea cycle enzyme activities. Kidney weight (g kg−1of BW) increased linearly (P=0.004) with increasing inclusion levels of DGS. There were no effects (P≥0.11) of dietary treatment on hepatic and renal GPx activity (U g−1, U mg−1of protein, and kU liver−1). Hepatic carbamoyl phosphate synthetase activity (kU liver−1and U kg−1of BW) tended to linearly increase (P=0.09 and P=0.10, respectively) with increasing inclusion level of DGS. Hepatic ornithine transcarbamoylase and argininosuccinate synthetase activity (kU liver−1and U kg−1of BW) increased linearly (P≤0.05) with increasing inclusion levels of DGS. These data indicate that steers adapt to feeding up to 50% DGS by increasing kidney mass and activity of urea cycle enzymes in liver to allow for clearance of excess nitrogen. Also, hepatic and renal GPx activity, as an indicator of Se status, is not affected when typical finishing diets are fed.

Contrôle des activités de l'argininosuccinate synthétase, de l'argininosuccinase et de l'arginase á la naissance chez le rat

1978 ◽  
Vol 56 (7) ◽  
pp. 734-737 ◽  
Author(s):  
A. Husson ◽  
R. Vaillant
Keyword(s):  
Postnatal Development ◽  
Enzyme Activities ◽  
Urea Cycle ◽  
Argininosuccinate Synthetase ◽  
Newborn Rats ◽  
Cycle Enzyme ◽  
Increased Activity ◽  
Adrenal Secretion ◽  
Urea Cycle Enzyme ◽  
Newborn Animals

Some factors influencing the postnatal development of three urea cycle enzyme activities, argininosuccinate synthetase, argininosuccinase, and arginase, in the liver of newborn rats, are studied.Premature and postmature birth change the developmental pattern of these enzyme activities, suggesting that the increase in enzyme activity after birth is initiated by the birth process.Starvation of newborn animals after birth has no effect on the postnatal development of the three enzyme activities.Bilateral adrenalectomy at birth causes a partial inhibition of the postnatal increase of argininosuccinase and arginase activities while injection of cortisol prevents the effects of adrenalectomy.It is suggested that presence of adrenal secretion is one condition necessary for the increased activity of the prematures.

scholarly journals Transient hyperammonaemia in an adult German shepherd dog : case report

1997 ◽  
Vol 68 (2) ◽  
Author(s):  
R.G. Lobetti ◽  
D.B. Miller ◽  
T. Dippenaar
Keyword(s):  
Case Report ◽  
Liver Disease ◽  
Urinary Tract ◽  
Drug Therapy ◽  
Urea Cycle ◽  
Urinary Tract Obstruction ◽  
German Shepherd ◽  
Cycle Enzyme ◽  
German Shepherd Dog ◽  
Urea Cycle Enzyme

A 3-year-old male German shepherd dog was presented with severe generalised seizures. The dog was protein-intolerant and showed severe hyperammonaemia on ammonia stimulation. The hyperammonaemic state was present for at least 6 weeks and then spontaneously resolved. No obvious cause (liver disease, portocaval shunts, urea cycle enzyme deficiencies, drug therapy or urinary tract obstruction) could be identified. It is possible that this dog had a variation of transient hyperammonaemic syndrome, described in man and recently in a juvenile Irish wolfhound, that extended into adulthood.

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