A Double-Blind Clinical Comparison between Nomifensine and Amitriptyline in the Treatment of Endogenous Depressions

1982 ◽  
Vol 17 (S1) ◽  
pp. 97-105 ◽  
Author(s):  
J.J. López-Ibor Aliño ◽  
J.L. Ayuso Gutierez ◽  
M.L. Montejo Iglesias ◽  
J.L. Ramons
Keyword(s):  
Double Blind ◽  
Clinical Comparison

scholarly journals A Clinical Comparison of Atracurium and Vecuronium in Women Undergoing Laparoscopy

1987 ◽  
Vol 15 (3) ◽  
pp. 310-316 ◽  
Author(s):  
M. A. Raynes ◽  
R. Chisholm ◽  
D. F. Woolner ◽  
J. M. Gibbs
Keyword(s):  
Sinus Bradycardia ◽  
Neuromuscular Block ◽  
Randomised Trial ◽  
Neuromuscular Monitoring ◽  
Double Blind ◽  
Duration Of Action ◽  
Prospective Randomised Trial ◽  
Clinical Comparison ◽  
Intraoperative Hypotension ◽  
Significant Difference

In a double blind, prospective, randomised trial in 30 women undergoing laparoscopy, atracurium and vecuronium were compared in equipotent (2 X ED95) doses. In the atracurium group, first twitch depression was significantly greater at one minute, and degree of fade significantly greater at one and two minutes, but thereafter neuromuscular monitoring showed no significant difference between the groups. Clinically there was no significant difference between the drugs. Mild intraoperative hypotension was equally common in both groups as was sinus bradycardia. Reversal and recovery were comparable in the two groups. Neostigmine was required in all patients and in three (one atracurium, two vecuronium) a second dose was administered on clinical grounds. Antagonism of the neuromuscular block is required with surgery of this duration despite the intermediate duration of action of the relaxant drugs.

A Clinical Comparison of Triazolam with Placebo and with Secobarbital in Insomniac Patients

1978 ◽  
Vol 6 (4) ◽  
pp. 343-347 ◽  
Author(s):  
K Kay Okawa ◽  
George S Allen
Keyword(s):  
Side Effects ◽  
Sleep Duration ◽  
Sleep Onset ◽  
Questionnaire Data ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Sleep Questionnaire ◽  
Clinical Comparison ◽  
Hypnotic Efficacy ◽  
Better Than

Seventy-six out-patient insomniacs participated in three different two-night, double-blind crossover trials investigating the hypnotic efficacy and safety of triazolam. Triazolam 0.5 mg was compared to placebo in one trial conducted by K Kay Okawa, MD, and triazolam 0.5 mg was compared to secobarbital 100 mg in trials conducted by K Kay Okawa, MD and George S Allen, MD. The results of the latter two studies were combined and the data analyzed jointly. Triazolam 0.5 mg was found to be preferred and to be significantly better than both placebo and secobarbital 100 mg in the treatment of insomnia. Analysis of sleep questionnaire data showed triazolam to be superior to either placebo or secobarbital on the following parameters: how much the medication helped the patient sleep; onset of sleep; duration of sleep; and number of nocturnal awakenings. No differences were observed between treatments in any trial with regard to the patient's feeling of alertness the next morning. The side-effects reported for all treatments did not significantly interfere with the patients' ability to function.

A Double-Blind Clinical Comparison of Two Dosage Schedules of Cefatrizine in Children

1988 ◽  
Vol 16 (3) ◽  
pp. 197-200
Author(s):  
P. Careddu ◽  
G. Ceccarelli
Keyword(s):  
Clinical Trial ◽  
Respiratory Tract ◽  
Bacterial Infection ◽  
Randomized Clinical Trial ◽  
Clinical Symptoms ◽  
Daily Administration ◽  
Bacterial Eradication ◽  
Double Blind ◽  
Once Daily ◽  
Clinical Comparison

A double-blind, randomized clinical trial was carried out to compare the effectiveness of twice daily versus once daily administration of the cephalosporin, cefatrizine, in paediatric outpatients with bacterial infection of the respiratory tract. Thirty children were studied, aged 7 years 2 months (range, 4–-12 years). They were given 75 mg/kg·day cefatrizine either once daily or twice daily at 12 h intervals for 8 days. Fever, clinical symptoms, bacterial eradication and overall tolerance were evaluated. No significant differences were observed between once daily or twice daily administration. This is in agreement with other studies carried out on adults. It is concluded that cefatrizine may be given to paediatric out-patients for the treatment of bacterial infection of the respiratory tract only once daily with good clinical and overall results.

scholarly journals Clinical Comparison of Atracurium and Alcuronium in Gynaecological Surgery

1985 ◽  
Vol 13 (1) ◽  
pp. 33-37 ◽  
Author(s):  
D. F. Woolner ◽  
J. M. Gibbs ◽  
P. Q. Smeele
Keyword(s):  
Surgical Procedures ◽  
Sinus Bradycardia ◽  
Randomised Trial ◽  
Clinical Problem ◽  
Gynaecological Surgery ◽  
Double Blind ◽  
Female Patients ◽  
Intubating Conditions ◽  
Prospective Randomised Trial ◽  
Clinical Comparison

In a double-blind, prospective, randomised trial in 51 female patients, atracurium 0.6mg/kg provided acceptable intubating conditions more rapidly than did alcuronium 0.25mg/kg. Atracurium produced more profound neuromuscular twitch suppression than alcuronium. The effect of atracurium was longer-lasting than that of alcuronium (32 minutes and 22 minutes respectively to achieve 10% recovery) and it took slightly longer to reverse with neostigmine. Seven patients in the atracurium group who underwent short surgical procedures required supplementary neostigmine to achieve adequate reversal. Two cases of sinus bradycardia were noted in the atracurium group, but hypotension was not a clinical problem in any patient. Atracurium appears to be a useful relaxant, but a smaller dose than that used here should be chosen for short procedures.

Plasma transfusion in liver transplantation: a randomized, double-blind, multicenter clinical comparison of three virally secured plasmas

Transfusion ◽  
2012 ◽  
Vol 53 (6) ◽  
pp. 1335-1345 ◽  
Author(s):  
Tonine Bartelmaos ◽  
Anne Chabanel ◽  
Julie Léger ◽  
Loïc Villalon ◽  
Marie Christine Gillon ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Plasma Transfusion ◽  
Double Blind ◽  
Clinical Comparison
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