Antipsychotic Effects of Caerulein, a Decapeptide Chemically Related to Cholecystokinin Octapeptide, on Schizophrenia

1982 ◽  
Vol 17 (4) ◽  
pp. 255-273 ◽  
Author(s):  
Noboru Watanabe ◽  
Norita Aoki ◽  
Shinji Itoh ◽  
Takashi Moroji
Keyword(s):  
Cholecystokinin Octapeptide

Analogues of the cholecystokinin octapeptide modified in the central part of the molecule

1991 ◽  
Vol 56 (9) ◽  
pp. 1963-1970 ◽  
Author(s):  
Jan Hlaváček ◽  
Václav Čeřovský ◽  
Jana Pírková ◽  
Pavel Majer ◽  
Lenka Maletínská ◽  
...  
Keyword(s):  
Amino Acid ◽  
Biological Activities ◽  
Point Of View ◽  
Biologically Active ◽  
Side Chain ◽  
Amino Acid Residues ◽  
Cholecystokinin Octapeptide ◽  
Biological Tests ◽  
Biological Potency ◽  
Biologically Active Conformation

In a series of analogues of the cholecystokinin octapeptide (CCK-8) the amino acid residues were gradually modified by substituting Gly by Pro in position 4, Trp by His in position 5, Met by Cle in position 6, or the Gly residue was inserted between Tyr and Met in positions 2 and 3 of the peptide chain, and in the case of the cholecystokinin heptapeptide (CCK-7) the Met residues were substituted by Nle or Aib. These peptides were investigated from the point of view of their biological potency in the peripheral and central region. From the results of the biological tests it follows that the modifications carried out in these analogues and in their Nα-Boc derivatives mean a suppression of the investigated biological activities by 2-3 orders of magnitude (at a maximum dose of the tested substance of 2 . 10-2 mg per animal).This means that a disturbance of the assumed biologically active conformation of CCK-8, connected with a considerable decrease of the biological potency of the molecule, takes place not only after introduction of the side chain into its centre (substitution of Gly4), but also after the modification of the side chains of the amino acids or by extension of the backbone in further positions around this central amino acid.

Influence of motilin and cholecystokinin on sphincter of Oddi and duodenal mobility

1987 ◽  
Vol 253 (5) ◽  
pp. G679-G683 ◽  
Author(s):  
E. L. Muller ◽  
P. A. Grace ◽  
R. L. Conter ◽  
J. J. Roslyn ◽  
H. A. Pitt
Keyword(s):  
Sphincter Of Oddi ◽  
Prairie Dogs ◽  
Prairie Dog ◽  
Cholecystokinin Octapeptide ◽  
Side Hole ◽  
Hole Pressure ◽  
Duodenal Motility ◽  
Sphincter Of Oddi Motility ◽  
Duodenal Lumen ◽  
Distal Port

The sphincter of Oddi and the duodenum exhibit cyclical activity in phase with the migrating myoelectric complex. Both motilin and cholecystokinin have been shown to modulate gastrointestinal and sphincter of Oddi motility. However, previous studies have not monitored the effects of these hormones on simultaneously recorded sphincter of Oddi and duodenum pressures. The present investigation was undertaken, therefore, to determine the influence of both motilin and cholecystokinin on simultaneously recorded sphincter of Oddi and duodenal motility. In seven anesthetized prairie dogs, a triple-lumen, side-hole, pressure-monitored perfusion catheter was positioned with the proximal port in the sphincter of Oddi and the distal port in the duodenal lumen. Sphincter of Oddi and duodenal motility was recorded before and during 20-min infusions of motilin and cholecystokinin octapeptide (CCK-8) at 1, 10, and 100 ng.kg-1.min-1. Both hormones produced dose-related increases in sphincter of Oddi and duodenal motility. No response was observed with either hormone at 1 ng.kg-1.min-1. At 10 ng.kg-1.min-1, the duodenum was slightly more sensitive to motilin than to CCK-8, while the sphincter of Oddi was equally affected by both hormones. At 100 ng.kg-1.min-1, both hormones stimulated the sphincter of Oddi and the duodenum equally. These data indicate that in the prairie dog, both motilin and cholecystokinin stimulate sphincter of Oddi and duodenal motility.

Responses to cholecystokinin octapeptide in patients with functional abdominal pain syndromes

1992 ◽  
Vol 7 (3) ◽  
pp. 293-297 ◽  
Author(s):  
IAN C. ROBERTS-THOMSON ◽  
MARTIN J. FETTMAN ◽  
JULIE R. JONSSON ◽  
DEREK B. FREWIN
Keyword(s):  
Abdominal Pain ◽  
Functional Abdominal Pain ◽  
Cholecystokinin Octapeptide ◽  
Pain Syndromes

Cholecystokinin octapeptide immunoreactivity in the nucleus tractus solitarius of the cat

Peptides ◽  
1989 ◽  
Vol 10 (1) ◽  
pp. 73-78 ◽  
Author(s):  
Kimberly A. Howes ◽  
Bruce W. Newton ◽  
Bruce E. Maley
Keyword(s):  
Nucleus Tractus Solitarius ◽  
Cholecystokinin Octapeptide

scholarly journals Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence

2012 ◽  
Vol 13 (1) ◽  
pp. 63 ◽  
Author(s):  
Di Wen ◽  
Chun-ling Ma ◽  
Ya-jing Zhang ◽  
Yan-xin Meng ◽  
Zhi-yu Ni ◽  
...  
Keyword(s):  
Morphine Dependence ◽  
Inhibitory Effects ◽  
Cholecystokinin Octapeptide ◽  
Cholecystokinin Receptor

Dual action of cholecystokinin-octapeptide on the guinea pig antrum

1987 ◽  
Vol 92 (2) ◽  
pp. 376-382 ◽  
Author(s):  
Masaru Kantoh ◽  
Toku Takahashi ◽  
Masato Kusunoki ◽  
Takehira Yamamura ◽  
Joji Utsunomiya
Keyword(s):  
Guinea Pig ◽  
Cholecystokinin Octapeptide ◽  
Dual Action
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