An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

2017 ◽  
Vol 30 (3) ◽  
pp. 146-158 ◽  
Author(s):  
Licia Genovese ◽  
Andrea Corbo ◽  
Sara Sibilla
Keyword(s):  
Bioactive Peptides ◽  
Dietary Intervention ◽  
Skin Texture ◽  
Insight Into

Insight into Keap1/Nrf2 pathway activation by new milk-derived bioactive peptides

2021 ◽  
Vol 177 ◽  
pp. S86-S87
Author(s):  
Federica Tonolo ◽  
Laura Moretto ◽  
Federico Fiorese ◽  
Alessandra Folda ◽  
Valeria Scalcon ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Nrf2 Pathway ◽  
Pathway Activation ◽  
Insight Into

Insight into antioxidant properties of milk‐derived bioactive peptides in vitro and in a cellular model

2019 ◽  
Vol 25 (5) ◽  
pp. e3162 ◽  
Author(s):  
Federica Tonolo ◽  
Laura Moretto ◽  
Stefania Ferro ◽  
Alessandra Folda ◽  
Valeria Scalcon ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Antioxidant Properties ◽  
Cellular Model ◽  
Insight Into

scholarly journals Crystal Structure of Human Thimet Oligopeptidase Provides Insight into Substrate Recognition, Regulation, and Localization

2004 ◽  
Vol 279 (19) ◽  
pp. 20480-20489 ◽  
Author(s):  
Kallol Ray ◽  
Christina S. Hines ◽  
Jerry Coll-Rodriguez ◽  
David W. Rodgers
Keyword(s):  
Crystal Structure ◽  
Active Site ◽  
Nuclear Import ◽  
Bioactive Peptides ◽  
Protein Protein Interaction ◽  
Human Enzyme ◽  
Deep Channel ◽  
Thimet Oligopeptidase ◽  
Degree Of Order ◽  
Insight Into

Thimet oligopeptidase (TOP) is a zinc metallopeptidase that metabolizes a number of bioactive peptides and degrades peptides released by the proteasome, limiting antigenic presentation by MHC class I molecules. We present the crystal structure of human TOP at 2.0-Å resolution. The active site is located at the base of a deep channel that runs the length of the elongated molecule, an overall fold first seen in the closely related metallopeptidase neurolysin. Comparison of the two related structures indicates hinge-like flexibility and identifies elements near one end of the channel that adopt different conformations. Relatively few of the sequence differences between TOP and neurolysin map to the proposed substrate-binding site, and four of these variable residues may account for differences in substrate specificity. In addition, a loop segment (residues 599-611) in TOP differs in conformation and degree of order from the corresponding neurolysin loop, suggesting it may also play a role in activity differences. Cysteines thought to mediate covalent oligomerization of rat TOP, which can inactivate the enzyme, are found to be surface-accessible in the human enzyme, and additional cysteines (residues 321,350, and 644) may also mediate multimerization in the human homolog. Disorder in the N terminus of TOP indicates it may be involved in subcellular localization, but a potential nuclear import element is found to be part of a helix and, therefore, unlikely to be involved in transport. A large acidic patch on the surface could potentially mediate a protein-protein interaction, possibly through formation of a covalent linkage.

scholarly journals Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer

2002 ◽  
Vol 87 (S2) ◽  
pp. S273-S281 ◽  
Author(s):  
B. Pool-Zobel ◽  
J. van Loo ◽  
I. Rowland ◽  
M. B. Roberfroid
Keyword(s):  
Colon Cancer ◽  
Animal Studies ◽  
Intestinal Tract ◽  
Intervention Studies ◽  
Dietary Intervention ◽  
Aberrant Crypt Foci ◽  
Protective Effects ◽  
Fermentation Products ◽  
Acid Producing Bacteria ◽  
Insight Into

Inulin is extracted from the chicory root. It is a set of fructans with its monomers (n=2–65) linked by means of β(2–1) bonds. This linkage cannot be hydrolysed by either pancreatic or by brush border digestive enzymes in the upper intestinal tract of humans. As such the carbohydrates arrive in the colon, where they are fermented by bifidobacteria and other lactic acid producing bacteria, thus enhancing their relative populations in the gut. Recent research in experimental animal models revealed that inulin has significant anticarcinogenic properties. It acts chemopreventively by reducing the incidence of azoxymethane (AOM) — induced aberrant crypt foci and tumours in the colon. These effects may be due to the stimulation of bifidobacteria, which themselves have been shown to act as antigenotoxic in the colon and to reduce AOM-induced tumours. Also fermentation products, including the short-chain fatty acid butyrate, could contribute to the protective effects. In this case a mechanism may be the induction of apoptosis of already transformed cells. The experimental evidence from animal studies and from studies elucidating potential mechanisms strongly supports the possibility that inulin will contribute to reducing risks for colon cancer in humans. In order to obtain more insight into this possibility, human dietary intervention studies relating biomarkers of reduced risk to inulin consumption are needed.

Protective effects of bioactive peptides in foxtail millet protein hydrolysates against experimental colitis in mice

2022 ◽  
Author(s):  
Bowei Zhang ◽  
Yingchuan Xu ◽  
Congying Zhao ◽  
Yunhui Zhang ◽  
Huan Lv ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Bioactive Peptides ◽  
Dietary Intervention ◽  
Foxtail Millet ◽  
Intervention Strategy ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Active Ingredients ◽  
Inflammatory Bowel

It is of great significance to develop a dietary intervention strategy to prevent inflammatory bowel disease (IBD). A millet-rich diet can ameliorate IBD, but the active ingredients and mechanisms remain...

scholarly journals Insight into the potential application of polyphenol-rich dietary intervention in degenerative disease management

2020 ◽  
Vol 11 (4) ◽  
pp. 2805-2825 ◽  
Author(s):  
Javier Quero ◽  
Inés Mármol ◽  
Elena Cerrada ◽  
María Jesús Rodríguez-Yoldi
Keyword(s):  
Disease Management ◽  
Potential Application ◽  
Dietary Intervention ◽  
Degenerative Disease ◽  
Insight Into ◽  
Nutraceutical Properties

In recent times, a great number of plants have been studied in order to identify new components with nutraceutical properties, among which are polyphenols.

Calibration problems in hydrogen luminosities

1966 ◽  
Vol 24 ◽  
pp. 322-330
Author(s):  
A. Beer
Keyword(s):  
Galactic Structure ◽  
B Stars ◽  
Insight Into

The investigations which I should like to summarize in this paper concern recent photo-electric luminosity determinations of O and B stars. Their final aim has been the derivation of new stellar distances, and some insight into certain patterns of galactic structure.

Stochasting modeling of planetary ring systems

1984 ◽  
Vol 75 ◽  
pp. 461-469 ◽  
Author(s):  
Robert W. Hart
Keyword(s):  
Maximum Entropy ◽  
Ring System ◽  
The Sun ◽  
Ultimate State ◽  
Interparticle Interactions ◽  
Ring Systems ◽  
First Order ◽  
Planetary Ring ◽  
Insight Into

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.

Skeletal elements of crinoid echinoderms: High-resolution structural and microanalytical results

1983 ◽  
Vol 41 ◽  
pp. 194-195
Author(s):  
D. F. Blake ◽  
L. F. Allard ◽  
D. R. Peacor
Keyword(s):  
High Resolution ◽  
Marine Invertebrates ◽  
Sea Urchins ◽  
Structural Features ◽  
Sea Stars ◽  
High Resolution Tem ◽  
Relationship Of ◽  
The Relationship ◽  
Insight Into

Echinodermata is a phylum of marine invertebrates which has been extant since Cambrian time (c.a. 500 m.y. before the present). Modern examples of echinoderms include sea urchins, sea stars, and sea lilies (crinoids). The endoskeletons of echinoderms are composed of plates or ossicles (Fig. 1) which are with few exceptions, porous, single crystals of high-magnesian calcite. Despite their single crystal nature, fracture surfaces do not exhibit the near-perfect {10.4} cleavage characteristic of inorganic calcite. This paradoxical mix of biogenic and inorganic features has prompted much recent work on echinoderm skeletal crystallography. Furthermore, fossil echinoderm hard parts comprise a volumetrically significant portion of some marine limestones sequences. The ultrastructural and microchemical characterization of modern skeletal material should lend insight into: 1). The nature of the biogenic processes involved, for example, the relationship of Mg heterogeneity to morphological and structural features in modern echinoderm material, and 2). The nature of the diagenetic changes undergone by their ancient, fossilized counterparts. In this study, high resolution TEM (HRTEM), high voltage TEM (HVTEM), and STEM microanalysis are used to characterize tha ultrastructural and microchemical composition of skeletal elements of the modern crinoid Neocrinus blakei.

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