Prolonged Holding of Whole Blood at 22 °C Does Not Increase Activation in Platelet Concentrates

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (4) ◽  
pp. 225-228 ◽  
Author(s):  
C. Sanz ◽  
A. Pereira ◽  
A.I. Faúndez ◽  
A. Ordinas
Keyword(s):  
Whole Blood ◽  
Platelet Concentrates ◽  
Prolonged Holding

Prolonged Holding of Whole Blood at 22 oC Does Not Increase Activation in Platelet Concentrates

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (4) ◽  
pp. 225-228 ◽  
Author(s):  
C. Sanz ◽  
A. Pereira ◽  
A.I. Faundez ◽  
A. Ordinas
Keyword(s):  
Whole Blood ◽  
Platelet Concentrates ◽  
Prolonged Holding

Evaluation of a new whole-blood filter that allows preparation of platelet concentrates by platelet-rich plasma methods

Transfusion ◽  
2003 ◽  
Vol 43 (12) ◽  
pp. 1723-1728 ◽  
Author(s):  
Maria L. Lozano ◽  
Elena Pérez-Ceballos ◽  
Jose Rivera ◽  
Dragica Paunovic ◽  
Maria J. Candela ◽  
...  
Keyword(s):  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Platelet Concentrates ◽  
Blood Filter ◽  
Plasma Methods

Eight-hour versus 24-h whole-blood hold before preparation of platelet concentrates by the platelet-rich plasma method

2014 ◽  
Vol 39 (4) ◽  
pp. 195
Author(s):  
GhadaM El-Gohary ◽  
AzzaS El-Danasoury ◽  
MahiraI El-Mogy ◽  
Amal Farouk ◽  
GhadaS Neseem
Keyword(s):  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Platelet Concentrates ◽  
Plasma Method

scholarly journals The Increased Effectiveness of Platelet Concentrates Prepared in Acidified Plasma

Blood ◽  
1966 ◽  
Vol 27 (4) ◽  
pp. 449-459 ◽  
Author(s):  
FREDERICK A. FLATOW ◽  
EMIL J. FREIREICH
Keyword(s):  
Citric Acid ◽  
Acid Medium ◽  
Whole Blood ◽  
Platelet Rich Plasma ◽  
Adenosine Diphosphate ◽  
Red Cells ◽  
Platelet Concentrates ◽  
Standard Methods ◽  
Aggregation Of Platelets ◽  
Concentrate Preparation

Abstract Platelet concentrates prepared in acidified plasma (pH 6.5-6.7) are superior to concentrates prepared by standard methods, and are 80-90 per cent as effective as platelet rich plasma (PRP). The use of excess citric acid to acidify plasma promotes resuspension of the concentrate by eliminating clumping, which is a major factor in the decreased effectiveness of standard concentrates. Analysis of posttransfusion recovery and survival of platelets reveals no evidence of platelet injury in an acid medium. Acidification of PRP inhibits the aggregation of platelets by adenosine diphosphate (ADP). The presence of endogenous ADP may be an important factor in clumping during standard concentrate preparation. A method of acidification of PRP using citric acid is described which allows preparation of an effective concentrate from fresh whole blood without subjecting the red cells to acid pH. Reconstitution of the acidified platelet poor plasma and its native red cells increases the citrate molarity by less than 6 per cent and results in minimal decrease in pH of the whole blood.

scholarly journals Comparative Studies of Platelet Survival by Different Methods in the Rabbit

Blood ◽  
1965 ◽  
Vol 25 (4) ◽  
pp. 548-566 ◽  
Author(s):  
SHIRLEY EBBE ◽  
MARIO BALDINI ◽  
JANET DONOVAN
Keyword(s):  
Survival Time ◽  
Whole Blood ◽  
Comparative Studies ◽  
Significant Degree ◽  
Human Platelets ◽  
Sodium Chromate ◽  
Platelet Concentrates ◽  
Rabbit Platelets

Abstract Four methods for measuring the survival of homologous platelets in rabbits were studied: (1) transfusion of nonradioactive platelet concentrates to thrombocytopenic recipients, (2) transfusion of concentrates of platelets labeled in vitro with Cr51-sodium chromate, (3) transfusion of concentrates of platelets labeled in vivo with P32-orthophosphate and (4) transfusion of whole blood labeled in vivo with P32-orthophosphate. The survival time of platelets in normal rabbits was 3-4 days. From comparison of the 3 methods using platelet concentrates, the following conclusions were drawn. (1) All the platelets in a platelet concentrate were capable of recirculating after transfusion. (2) Labeling with P32 or Cr51 did not damage platelets. (3) About one-third of the Cr51 was immediately eluted from viable platelets after they were transfused. (4) Further exchange of the label in vivo did not occur to a significant degree with either Cr51 or P32. (5) Cr51 did not elute from platelets during storage of the platelets. (6) Studies of rabbit platelets had applicability in predicting the behavior of human platelets.

Bacterial contamination of platelet concentrates: results of a prospective multicenter study comparing pooled whole blood?derived platelets and apheresis platelets

Transfusion ◽  
2007 ◽  
Vol 47 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Hubert Schrezenmeier ◽  
Gabriele Walther-Wenke ◽  
Thomas H. Müller ◽  
Franz Weinauer ◽  
Adelheid Younis ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Whole Blood ◽  
Bacterial Contamination ◽  
Platelet Concentrates ◽  
Prospective Multicenter Study ◽  
Apheresis Platelets

Generation of kinins during preparation and storage of whole blood?derived platelet concentrates

Transfusion ◽  
2007 ◽  
Vol 47 (3) ◽  
pp. 410-420 ◽  
Author(s):  
Marie Eve Moreau ◽  
Louis Thibault ◽  
Anik Désormeaux ◽  
Miguel Chagnon ◽  
Réal Lemieux ◽  
...  
Keyword(s):  
Whole Blood ◽  
Platelet Concentrates ◽  
And Storage
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