Positive Direct Antiglobulin Test due to Antiphospholipid Antibodies in Normal Healthy Blood Donors

Vox Sanguinis ◽  
1997 ◽  
Vol 72 (3) ◽  
pp. 182-184 ◽  
Author(s):  
Nay Win ◽  
S.I.A.M. Islam ◽  
M.A. Peterkin ◽  
I.D. Walker
Keyword(s):  
Antiphospholipid Antibodies ◽  
Blood Donors ◽  
Direct Antiglobulin Test ◽  
Antiglobulin Test ◽  
Positive Direct

scholarly journals The investigation of the significance of a positive direct antiglobulin test in blood donors

2020 ◽  
Vol 18 (3) ◽  
pp. 78-81
Author(s):  
Marianna Bellia ◽  
John Georgopoulos ◽  
Vasilis Tsevrenis ◽  
Efrosini Nomikou ◽  
Niki Vgontza ◽  
...  
Keyword(s):  
Blood Donors ◽  
Direct Antiglobulin Test ◽  
Antiglobulin Test ◽  
Positive Direct

Blood Donors with a Positive Direct Antiglobulin Test Are at Increased Risk for Hematologic Malignancies and Cancer in General.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2903-2903
Author(s):  
Yakir Rottenberg ◽  
Vered Yahalom ◽  
Eilat Shinar ◽  
Bella Adler ◽  
Ora Paltiel
Keyword(s):  
Multiple Myeloma ◽  
Hodgkin Lymphoma ◽  
Blood Donors ◽  
Hematologic Malignancies ◽  
Direct Antiglobulin Test ◽  
Increased Risk ◽  
Antiglobulin Test ◽  
Positive Direct ◽  
Hematopoietic Cancer

Abstract Positive direct antiglobulin tests (DAT) may be non-specific or associated with auto-antibodies and malignancies, including multiple myeloma and lymphoproliferative disorders. Screening blood donations for DAT is not routinely performed. Furthermore, it is unknown whether a positive DAT in healthy donors is associated with an increased risk of malignancy. All blood donations at MDA National Blood Services in Israel undergo Autocontrol (AC) testing using automated blood grouping equipment (Autogrouper© 1986–2000, and Olympus PK7200© from 2000-present). AC-positive donations are tested for DAT using tubes and/or Diamed gel cards with anti-IgG, anti-C3 and anti-IgG/C3. Donors with positive DAT tests were identified from 1999–2003 and matched in a 1:4 ratio to DAT-negative donors for sex, year of donation and age (by 5 year categories). Cancer incidence was ascertained through July 30, 2006 via the Israel Cancer Registry. We compared the incidence of all cancers, hematopoietic, and solid tumors among DAT+ and DAT– donors. We also compared cancer rates in DAT+ donors with the expected rates in the general Israeli population, controlling for age, sex and ethnicity. Results: The final study population included 586 DAT+ and 2344 DAT– donors. In both groups 62.6% were males, and the mean age of the DAT+ donors was 34.5 (range: 17–67) compared to 32.0 (11–74) years in DAT– donors. Malignancies occurred in 17 (2.9%) of the DAT+ and 27 (1.2%) of the DAT– donors during the follow-up period; of these, three donors in the DAT+ group were diagnosed with hematopoietic cancer within 12 months of their donation (Hodgkin lymphoma within 2 months, non-Hodgkin lymphoma within 4 months and multiple myeloma within 8 months). Even after excluding these early cases and with a mean follow up of 66 months (range: 14–91 months), the relative risk (RR) of developing cancer was 2.14 (95% confidence interval (CI): 1.13–4.10) comparing donors with positive DAT to those with negative DAT, while the RR for hematopoietic cancer was 8.3 (95% CI: 1.5–43.2). Comparing DAT+ blood donors with the general population, the standardized incidence ratios (observed/expected cases) were elevated at 2.11 (95% CI: 1.15–3.54, p=0.016) for all malignancies and 8.03 (95% CI: 2.2–20.6, p=0.003) for hematologic malignancies, while they were not increased in the DAT negative group. Among DAT+ donors, the most frequent malignancies were lymphoma, multiple myeloma, thyroid, prostate and gastrointestinal tumors (2 cases in each category). Conclusion: There is evidence of a significantly increased risk of cancer, especially hematologic malignancies, among blood donors with a positive DAT, within a short follow-up period. A positive direct antiglobulin test thus appears to be a risk marker for malignancy. Further studies are necessary to confirm these findings, assess their significance, and determine whether the DAT would be a useful aid to early detection of cancer in healthy populations.

scholarly journals Positive direct antiglobulin test in voluntary blood donors: A case report

2013 ◽  
Vol 29 (1) ◽  
pp. 819-822
Author(s):  
Andrijana Kulic ◽  
Vesna Libek ◽  
Ana Strugar ◽  
Nada Rankovic
Keyword(s):  
Case Report ◽  
Blood Donors ◽  
Direct Antiglobulin Test ◽  
Antiglobulin Test ◽  
Positive Direct

scholarly journals Positive Direct Antiglobulin Test in COVID-19 patients: decision-making process

2021 ◽  
Author(s):  
Julien Cabo ◽  
Alice Brochier ◽  
Pascale Saussoy ◽  
Marie-Astrid van Dievoet ◽  
Lena Capirchio ◽  
...  
Keyword(s):  
Decision Making ◽  
Direct Antiglobulin Test ◽  
Decision Making Process ◽  
Antiglobulin Test ◽  
Positive Direct

Pregnancy‐associated haemolytic anaemia: A cause not to be forgotten

2021 ◽  
pp. 1753495X2110453
Author(s):  
Katherine Creeper ◽  
Dorothy Graham
Keyword(s):  
Corticosteroid Therapy ◽  
Haemolytic Anaemia ◽  
Direct Antiglobulin Test ◽  
Haemolytic Disease ◽  
Haematological Response ◽  
Antiglobulin Test ◽  
Multiparous Women ◽  
Anaemia In Pregnancy ◽  
Positive Direct ◽  
In Pregnancy

Anaemia in pregnancy is common, however, only a few cases of pregnancy-associated autoimmune haemolytic anaemia have been documented. Typically, such cases involve a positive direct antiglobulin test and have the potential to cause haemolytic disease of the fetus and newborn. Rarely, no autoantibodies are detected. We report two cases of direct antiglobulin test negative haemolytic anaemia occurring in multiparous women with no cause found. Both women had a haematological response to corticosteroid therapy and delivery.

scholarly journals Positive direct antiglobulin test in post-artesunate delayed haemolysis: more than a coincidence?

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Daniel Camprubí ◽  
Arturo Pereira ◽  
Natalia Rodriguez-Valero ◽  
Alex Almuedo ◽  
Rosauro Varo ◽  
...  
Keyword(s):  
Direct Antiglobulin Test ◽  
Antiglobulin Test ◽  
Delayed Haemolysis ◽  
Positive Direct

scholarly journals A-B Hemolytic Disease of the Newborn

Blood ◽  
1955 ◽  
Vol 10 (1) ◽  
pp. 17-28 ◽  
Author(s):  
RICHARD E. ROSENFIELD ◽  
FLORENCE EISINGER
Keyword(s):  
Reticulocyte Count ◽  
Umbilical Vein ◽  
Osmotic Fragility ◽  
Blood Groups ◽  
Direct Antiglobulin Test ◽  
Hemolytic Disease ◽  
Antiglobulin Test ◽  
Plasma Bilirubin ◽  
The Mean ◽  
Positive Direct

Abstract A study was made of oxalated umbilical vein blood of nearly every infant born at The Mount Sinai Hospital in a nine month period. A specimen of maternal blood was available for intragroup antibody screening and six cases of Rh-Hr hemolytic disease were eliminated from the data. The umbilical vein blood was tested, where possible, for: (1) group and Rh, (2) direct antiglobulin test, (3) hemoglobin, (4) reticulocyte count and examination of red cell morphology, (5) plasma bilirubin, and (6) osmotic fragility in 0.52 per cent NaCl. From the mothers’ blood groups, the infants were classified into group compatible and group incompatible, and the arithmetic means of the hemoglobin, reticulocyte count, and plasma bilirubin obtained for each class. A third class of infants, those with positive direct antiglobulin test, were analysed separately for comparison. 1. A weakly positive direct antiglobulin test was obtained on the umbilical vein blood of over 11 per cent of group incompatible infants but in none of the group compatible infants. 2. It appears that the weakly positive direct antiglobulin test detects an abnormal class of group incompatible infants, since their mean hemoglobin is low, their mean reticulocyte count is high, and their mean bilirubin is high, when these means are compared with those of the other group incompatible infants. 3. Thirty-eight of thirty-nine mothers of incompatible infants with positive direct antiglobulin test were group O. In comparison with the distribution of the blood groups of the mothers of other incompatible infants, this disproportion is of significance. 4. The mean reticulocyte count of incompatible infants with negative direct antiglobulin test is slightly (but with statistical significance) higher than the mean reticulocyte count of compatible infants. This difference was found to be associated almost entirely with group O mothers. 5. Thirty-one out of thirty-eight infants with positive direct antiglobulin test had increased osmotic fragility in hypotonic NaCl. Two of the negative cases appeared to have slight spherocytosis on blood smear.

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