Bilirubin and Paranitrophenol Glucuronyl Transferase Activities of the Liver in Patients with Gilbert’s Syndrome. An Attempt at a Biochemical Breakdown of the Gilbert’s Syndrome

Enzyme ◽  
1976 ◽  
Vol 21 (2) ◽  
pp. 97-107 ◽  
Author(s):  
C. Auclair ◽  
J. Hakim ◽  
P. Boivin ◽  
H. Troube ◽  
J. Boucherot
Keyword(s):  
Gilbert’S Syndrome ◽  
Glucuronyl Transferase ◽  
Gilbert's Syndrome

Effect of gilbert's syndrome associated polymorphic alleles (rs8175347 and rs4148323) of UDP-glucuronyl transferase on serum bilirubin level

Meta Gene ◽  
2020 ◽  
Vol 26 ◽  
pp. 100788
Author(s):  
Azadeh Aliarab ◽  
Bahram Yaghmaei ◽  
Sayyed Mohammad Hossein Ghaderian ◽  
Masoud Khoshnia ◽  
Gholamreza Roshandel ◽  
...  
Keyword(s):  
Bilirubin Level ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Gilbert’S Syndrome ◽  
Glucuronyl Transferase ◽  
Gilbert's Syndrome

Effect of Phenobarbitone on Plasma [14C]Bilirubin Clearance in Patients with Unconjugated Hyperbilirubinaemia

1974 ◽  
Vol 46 (1) ◽  
pp. 1-17 ◽  
Author(s):  
M. Black ◽  
J. Fevery ◽  
D. Parker ◽  
J. Jacobson ◽  
Barbara H. Billing ◽  
...  
Keyword(s):  
Plasma Clearance ◽  
Normal Subjects ◽  
Transferase Activity ◽  
Bilirubin Concentration ◽  
Gilbert’S Syndrome ◽  
Glucuronyl Transferase ◽  
Tracer Dose ◽  
Gilbert's Syndrome ◽  
Plasma Bilirubin ◽  
Relative Deficiency

1. The clearance of a tracer dose of [14C]bilirubin from the plasma was studied in patients with Gilbert's syndrome, congenital non-haemolytic jaundice, haemolytic jaundice and in normal subjects. Clearance was significantly impaired in the patients with Gilbert's syndrome and in those with congenital non-haemolytic jaundice when compared with the normal subjects, and was normal in the patient with haemolytic jaundice. 2. Treatment for 2 weeks with phenobarbitone (180 mg/day) lowered the plasma bilirubin concentration and improved all indices of plasma clearance of the isotope in patients with Gilbert's syndrome, so that they became indistinguishable from those of normal subjects. The improvement in plasma [14C]bilirubin clearance in these patients was associated with modest increases in hepatic bilirubin glucuronyl transferase in some subjects. 3. Phenobarbitone treatment improved plasma bilirubin concentrations and plasma [14C]bilirubin clearance in patients with congenital non-haemolytic jaundice, so that they resembled those seen in patients with untreated Gilbert's syndrome. Despite this improvement hepatic bilirubin glucuronyl transferase activity remained undetectable. 4. These results are compatible with the hypothesis that Gilbert's syndrome is a manifestation of a relative deficiency of hepatic bilirubin glucuronyl transferase, and differs from congenital non-haemolytic jaundice only in severity.

A familial Mediterranean fever girl due to MEFV N679H mutation with Gilbert’s syndrome

2021 ◽  
Author(s):  
Yuki Fujimaki ◽  
Takehiko Soutome ◽  
Takayuki Tanaka ◽  
Takeshi Shiba ◽  
Misa Watanabe
Keyword(s):  
Familial Mediterranean Fever ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Mediterranean Fever

A Case of Acquired Gilbert’s Syndrome

2016 ◽  
Vol 56 (12) ◽  
pp. 1164-1166
Author(s):  
Jonathan Leong ◽  
Maria-Stella Serrano
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

Predicted homozygous mis-sense mutation in Gilbert's syndrome

The Lancet ◽  
1995 ◽  
Vol 346 (8988) ◽  
pp. 1494 ◽  
Author(s):  
Yoko Soeda ◽  
Kazuo Yamamoto ◽  
Yukihiko Adachi ◽  
Takeshi Hori ◽  
Sachiko Aono ◽  
...  
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE

The Lancet ◽  
1970 ◽  
Vol 295 (7661) ◽  
pp. 1359-1362 ◽  
Author(s):  
Martin Black ◽  
Sheila Sherlock
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

Isotretinoin usage particularities in acne therapy in patients with Gilbert’s syndrome

2021 ◽  
Vol 20 (3) ◽  
pp. 53
Author(s):  
E.S. Negasheva ◽  
D.A. Blinova ◽  
M.S. Kornyat ◽  
S.A. Polevshchikova ◽  
N.F. Zatorskaya ◽  
...  
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Acne Therapy

scholarly journals A case of concomitant Gilbert's syndrome and hereditary spherocytosis

2010 ◽  
Vol 16 (3) ◽  
pp. 321 ◽  
Author(s):  
Hee Jung Lee ◽  
Hee Seok Moon ◽  
Eaum Seok Lee ◽  
Seok Hyun Kim ◽  
Jae Kyu Sung ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome
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