scholarly journals Vitamin D Status, Gender Differences, and Cardiometabolic Health Disparities

2017 ◽  
Vol 70 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Dharambir K. Sanghera ◽  
Bishwa R. Sapkota ◽  
Christopher E. Aston ◽  
Piers R. Blackett
Keyword(s):  
Gender Differences ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Fasting Glucose ◽  
Serum Vitamin ◽  
Cardiometabolic Health ◽  
Model Assessment ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
The Relationship

Background: Vitamin D deficiency is an unrecognized epidemic found in India and also worldwide. Despite the high prevalence of diabetes among Indians, there is a paucity of data showing the relationship between vitamin D status and cardiometabolic disparities. In this study, we have examined the relationship between vitamin D and cardiometabolic traits in a population from India. Methods: Circulating 25(OH)D levels were measured in 3,879 participants from the Asian Indian Diabetic Heart Study using ELISA kits. Results: Vitamin D levels were significantly reduced (p < 0.0001) in both men and women with obesity. However, compared to women, serum vitamin D was consistently lower in men (p < 0.02), irrespective of the presence of obesity and type 2 diabetes. Multivariate regression revealed strong interaction of vitamin D with body mass index that resulted in increased fasting glucose (p = 0.001) and reduced homeostasis model assessment of β-cell function (HOMA-B; p = 0.01) in normoglycemic individuals. However, in gender-stratified analysis, this association was restricted to men for both fasting glucose (p = 2.4 × 10-4) and HOMA-B (p = 0.001). Conclusions: Our findings suggest that vitamin D deficiency may significantly enhance the risk of cardiometabolic disease among Asian Indians. Future randomized trials and genetic studies are expected to clarify the underlying mechanisms for gender differences in vitamin D deficiency, and whether vitamin D-driven improvement in testosterone may contribute to beneficial cardiometabolic outcomes in men.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Vitamin D Deficiency in Patients With Idiopathic and Traumatic Osteochondritis Dissecans of the Talus

2019 ◽  
Vol 40 (11) ◽  
pp. 1309-1318 ◽  
Author(s):  
Lukas Fraissler ◽  
Sebastian Philipp Boelch ◽  
Thomas Schäfer ◽  
Matthias Walcher ◽  
Jörg Arnholdt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Osteochondritis Dissecans ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Foot And Ankle ◽  
Level Of Evidence ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Background: Low vitamin D levels are common in patients with foot and ankle disorders. We have previously demonstrated that juveniles diagnosed with osteochondritis dissecans (OCD) have a high prevalence of vitamin D deficiency. Moreover, there is evidence that OCD might be related to vitamin D deficiency in general. However, whether or not hypovitaminosis D is associated with OCD of the talus has yet to be elucidated. Methods: The aim of this study was to determine serum vitamin D levels [25(OH)D] of patients diagnosed with traumatic and idiopathic OCD of the talus. The vitamin D status of patients was measured and correlated to age, sex, season, etiology, laterality, degree of disease, and nicotine abuse. Moreover, parathyroid hormone and serum calcium levels of patients were obtained to assess for severe vitamin D deficiency and secondary hyperparathyroidism. Between January 2015 and December 2017, 65 patients with a mean age of 38.9 years and a total of 68 lesions were identified. Results: In total, 75.4% of patients had low vitamin D levels with a mean overall 25(OH)D level of 24.2 ng/mL. Specifically, 35.4% of patients were vitamin D deficient; another 40% were vitamin D insufficient, and only 24.6% of patients presented with sufficient vitamin D levels. Statistical analysis showed no significant difference comparing vitamin D levels of patients with idiopathic OCD to patients with traumatic OCD. Conclusion: We could not find any significant differences in the vitamin D status of patients with OCD of the talus compared with patients with foot and ankle disorders in general. However, we found that vitamin D deficiency was frequent in patients presenting with traumatic and idiopathic OCD of the talus. We believe it might be beneficial to routinely assess and treat the vitamin D status of patients. Level of Evidence: Level III, retrospective comparative study.

scholarly journals Study of Serum Vitamin D Level in Different Socio-Demographic Population - A Pilot Study

2017 ◽  
Vol 19 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Homayra Tahseen Hossain ◽  
Quazi Tarikul Islam ◽  
Md Abul Kashem Khandaker ◽  
HAM Nazmul Ahasan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Adult Patients ◽  
Vitamin D Status ◽  
College Hospital ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Population

Background: Recently, we see in our clinical practice that many patients who are coming with generalized body aches and pains and diagnosed as fibromyalgia or chronic fatigue, not adequately responding to treatment. When their vitamin D level was done, it was found to be low and correction of their low vitamin D level improved their symptoms dramatically. Despite abundant sunshine in Bangladesh, allowing vitamin D synthesis all the year round, why our people are developing hypovitaminosis D inspired us to do this current study. Our present study is designed to estimate the prevalence of vitamin D deficiency among adult patients presented with aches & pains as well as to study the association of low vitamin D levels with different socio-demographic parameters.Methods: A cross sectional observational study was conducted among 212 adult patients aged 18 years and above presented with generalized body aches and pains, attended both outpatient and inpatient departments of Popular Medical College Hospital during the period of March’16- August’16 ( 6 months). Association between vitamin D status & the individual specific variables was statistically analyzed.Results: The prevalence of vitamin D deficiency among the study population was found to be100% in all age groups. Among 212 study population, 73.6% were female (n=156) & 26.4% were male (n=56). Mean Vitamin D level among male was 14.29 (SD 4.68) & among female was 12.64 (SD 4.74). The factors associated with severely deficient Vitamin D level were female sex, urban population, &obesity. It is alarming that 64.2% of our study population were totally unaware about the importance of sun exposure.Conclusions: Vitamin D status was associated with a number of socio-demographic variables. Knowledge of these variables may improve targeted education and public health initiatives.J MEDICINE Jan 2018; 19 (1) : 22-29

scholarly journals Coronavirus in HIP Fractures CHIP 2: Is Vitamin D Deficiency Associated with Increased Mortality from COVID-19 Infections in A Hip Fracture Population?

2021 ◽  
Vol 3 (6) ◽  
pp. 111-116
Author(s):  
A. Mahmood ◽  
F. Rashid ◽  
D. Hawkes ◽  
W. J. Harrison
Keyword(s):  
Vitamin D ◽  
Hip Fracture ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Primary Outcome Measure ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Fracture Population ◽  
The Impact ◽  
The Relationship

Purpose: There is controversy as to whether vitamin D deficiency is associated with increased mortality from coronavirus infection. The aim of the study was to assess the relationship between vitamin D levels and 30-day mortality in hip fracture patients co-infected with COVID-19. Methods: This was a national observational audit conducted between 23 March 2020 (start of UK lockdown) and 31st December 2020. The cohort consisted of patients aged >60 years presenting with a hip fracture. Patients were included if they had a vitamin D level done during the admission episode, diagnosis of COVID-19 infection via a viral reverse transcriptase PCR swab, and a hip fracture. There were 517 patients included in the study from 43 different hospital trusts. The primary outcome measure was 30-day mortality. Secondary outcomes were the percentage of patients who had vitamin D deficiency, the percentage of patients who were prescribed Vitamin D, and the impact of vitamin D prescribing on mortality Results: Vitamin D deficiency was not associated with a higher 30-day mortality. Low serum vitamin D was observed in 56% of the patients on admission. Vitamin D was prescribed prior to admission in 28% and during admission in a further 49%. Pre-hospital vitamin D therapy reduced the chance of vitamin D deficiency. Starting vitamin D before or on admission did not affect the mortality rates. Conclusion: Vitamin D deficiency was common, but not associated with a higher 30-day mortality in the hip fracture population co-infected with COVID-19.

scholarly journals STUDY TO EVALUATE THE VITAMIN D SCENARIO IN AN INDIAN POPULATION

2021 ◽  
pp. 1-2
Author(s):  
Firdushi Begum ◽  
Papori Borah
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Institute Of Medicine ◽  
Vitamin D Status ◽  
Endocrine Society ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Introduction : Till the 20th century deficiency of vitamin D which is synthesized in the skin upon exposure to UVB light was largely unknown. But today vitamin D deficiency has taken an epidemic form and is linked with many disease conditions. Several studies have put forward a very high prevalence of vitamin D deficiency among Indians of all age groups. Aims and objectives : To study the vitamin D status of people visiting a tertiary care centre in India. Materials and Methods : This is a prospective observational study conducted in the Biochemistry section of Central Clinical Laboratory of Gauhati Medical College & Hospital (GMCH). All the vitamin D reports generated in the laboratory for a period of 9 months were recorded and analysed to estimate the prevalence. Similar to other vitamin D studies, 20ng/ml was taken as the cut-off for vitamin D deficiency, 30ng/ml for insufficiency, and 30-100ng/ml as the normal vitamin D range. Results and Observations : In this study Vitamin D data of 1000 patients admitted in GMCH was analysed. Of them females outnumbered males (68.7% vs 31.3%). Of the 1000 vitamin D reports analysed 51.9% were found to be in the insufficient range, followed by 30.1% in the normal range. In 17.5% vitamin D levels were found to be deficient Vitamin D status was found to be lower in females as compared to males. 86.75% of females were either vitamin D deficient or insufficient and 71.88% of males were either deficient or insufficient. Conclusion : In this study 17.5% of study subjects had vitamin D level <20ng/ml, which may be considered as deficient, as per the Institute of Medicine(IOM) which considers a serum vitamin D value of 20 ng/ml as optimal. According to the U.S. Endocrine Society 30 ng/ml is optimal. Due to this variation the recommended daily intakes of this nutrient also vary.

scholarly journals Vitamin D Status in Dupuytren’s Disease: Association with Clinical Status and Vitamin D Receptor Expression

2020 ◽  
Author(s):  
Jin Woo Park ◽  
Sung Taeck Kim ◽  
Kyu Sang Lee ◽  
Hyun Sik Gong
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Receptor ◽  
Serum Vitamin ◽  
Receptor Expression ◽  
Healthy Controls ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Tgf Β1

Abstract BackgroundDupuytren’s disease(DD) is a progressive fibroproliferative condition involving contractures of the fascia of the palm. Up to now, there are no relevant investigations on patients with DD in case of serum vitamin D deficiency. We hypothesized that transforming growth factor-β1 (TGF-β1) is increased in patients with DD in consequence of vitamin D deficiency, thereby leading to myofibroblast differentiation and subsequent progression of contractures. MethodsThe study’s aim was to analyze serum vitamin D levels and explore possible clinical and immunohistochemical correlates with vitamin D concentrations in a group of patients with DD. Vitamin D levels were measured in all DD patients and healthy controls. In the patient group, clinical characteristics were compared between vitamin D deficient and non-deficient subgroups. Diseased palmar fascia samples were obtained from 14 patients undergoing fasciectomy for DD. Correlations between vitamin D levels and vitamin D receptor(VDR), TGF-β1 expression levels in collected fascia samples were evaluated. ResultsVitamin D concentrations were significantly lower in patients than healthy controls. In addition, total extension deficit of involved fingers was higher in vitamin D deficient patients. Moreover, a positive correlation was found between vitamin D levels and expression of VDR in pathologic fascia in patients undergoing fasciectomy for contracture. Serum vitamin D levels were found to be low in DD patients. Expression of VDR was lower in the vitamin D deficient group.ConclusionsThe results suggest a potential link between vitamin D status and DD but causation is not yet established. The potential role of vitamin D and its interaction with VDR and the TGF-β1 signaling pathway in the pathogenesis of DD needs to be explored further.

Serum vitamin D status does not correlate with the severity of obstructive sleep apnea in male adults: A controlled study design with minimized factors influencing serum vitamin D levels

2020 ◽  
Vol 90 (5-6) ◽  
pp. 470-476 ◽  
Author(s):  
Ozge Yagcioglu Yassa ◽  
Saime Fusun Domac ◽  
Gulay Kenangil
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Significant Relationship ◽  
Serum Vitamin ◽  
Controlled Study ◽  
Vitamin D Status ◽  
Anthropometric Measures ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract. Observational studies performed in homogeneous groups to objectively investigate the cause and effect relationship between vitamin D deficiency and sleep disorders are scarce. In this study, it was aimed to analyze the relationship between the severity of OSAS and vitamin-D levels among the participants whose features affecting serum vit-D levels were minimised. Serum 25-OH vitamin-D levels in 121 OSAS Male patients diagnosed by polysomnography without any systemic disease or vitamin-D supplement that may effect the vitamin-D metabolism were measured. The study was conducted in winter (latitude: 41°). Anthropometric measures and biochemical tests were also performed. The distribution of vitamin-D levels was determined as severe deficiency, deficiency, insufficiency and sufficiency. Apnea-hypopne index (AHI) < 5 was considered as a control group. Patients were categorized into four groups according to AHI as control, mild, moderate and severe. The groups were similar in terms of age, BMI, lipid profile, serum calcium, anthropometric measures and smoking. There was no significant difference in the distribution of vitamin-D levels between the patient and control groups and also within OSAS subgroups (p = 0.57, p = 0.86, respectively). Odds ratio to have OSAS in patients with vitamin-D deficiency was found as 0.745 (95 %CI: 0.33–1.7). Multinominal regression analysis showed no significant relationship between the OSAS severity and the extent of vitamin-D status. Correlation analysis showed no significant relationship between vitamin-D and AHI (r = 0.017, p = 0.877). Vitamin-D status does not alter the severity of OSAS. Vitamin-D deficiency might be the result of lifestyle changes due to OSAS rather than a cause.

scholarly journals Role Of Vitamin D And Adipose Tissue Hormones In Women With Reproductive Disorders

Folia Medica ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 5-10
Author(s):  
Presiyana V. Nyagolova ◽  
Mitko D. Mitkov ◽  
Maria M. Orbetsova
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovary ◽  
Serum Vitamin ◽  
Reproductive Function ◽  
Reproductive Disorders ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Abstract The role of vitamin D beyond that it plays in bone metabolism and calcium homeostasis has been lately quite emphasized. In this respect, vitamin D deficiency has been associated with higher risk of cardiovascular disease, metabolic syndrome, and reproductive disorders. Growing evidence has suggested that vitamin D deficiency is implicated in the pathogenesis of insulin resistance and the development of metabolic disorders in the polycystic ovary syndrome. The goal of the review is to present contemporary concepts of the relationship between hormones affecting the metabolic body status, serum vitamin D levels and the reproductive function.

The association between vitamin D levels and precocious puberty: a meta-analysis

2020 ◽  
Vol 33 (3) ◽  
pp. 427-429
Author(s):  
Shanshan Liu ◽  
Xun Zhu ◽  
Yuanxin Wang ◽  
Shoumeng Yan ◽  
Dong Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Precocious Puberty ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Comprehensive Search ◽  
Vitamin D Supplements ◽  
The Relationship

AbstractThe objective of this short communication was the relationship between vitamin D and precocious puberty (PP). In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between vitamin D deficiency and PP. Studies that compared serum vitamin D levels between patients with PP and controls were selected for the systematic meta-analysis. The main outcome was the mean difference in serum vitamin D levels between PP and controls. Vitamin D-deficient subjects were more likely to develop PP. Our findings suggest that PP may be linked to vitamin D deficiency. Thus, providing supplements of vitamin D to PP patients may improve their nutritional status and prevent diseases. But, the amount of vitamin D required is uncertain, so it is important to be careful when taking vitamin D supplements.

scholarly journals Vitamin D Deficiency and Increased Risk of Bladder Carcinoma: A Meta-Analysis

2015 ◽  
Vol 37 (5) ◽  
pp. 1686-1692 ◽  
Author(s):  
Hui Zhang ◽  
Hui Zhang ◽  
Xiuhua Wen ◽  
Yonggang Zhang ◽  
Xueli Wei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bladder Carcinoma ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Carcinoma Risk

Background/Aims: Vitamin D status in relation to bladder carcinoma risk was still inconsistent. This study was carried out to evaluate the relationship between vitamin D status and bladder carcinoma risk through a meta-analysis approach. Methods: Pubmed, Web of Science, CNKI, and Embase were searched systemically to find eligible studies from the earliest available date to April 16, 2015. The search terms “vitamin D”, “25-hydroxyvitamin D”, “bladder cancer” or “bladder carcinoma” were used to retrieve relevant studies. The exposure of interest was intake of vitamin D or serum vitamin D levels, and the outcome of interest was bladder carcinoma incidence or mortality. The pooled risk ratio (RR) values and their 95%CIs were calculated through meta-analysis. Results: Seven studies with a total of 62,141 participants met the inclusion criteria and were finally included into the meta-analysis. There was no heterogeneity among those included studies (I2 = 0%, P = 0.53). The pooled RR of bladder carcinoma for the lowest category versus the highest category of vitamin D was 1.34 (95% CI 1.17-1.53, P < 0.0001). Sensitivity analysis by omitting one study by turns showed all the pooled RRs were statistically significant. Meta-analysis of 5 studies reporting outcomes of serum vitamin D levels also showed that the low serum vitamin D level was associated with increased risk of bladder carcinoma (RR = 1.32, 95%CI 1.15-1.52, P = 0.0001). No obvious risk of publication bias was observed. Conclusion: Vitamin D deficiency is associated with increased risk of bladder carcinoma in present study.

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