scholarly journals Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain

2016 ◽  
Vol 74 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Clement C. Zai ◽  
Arun K. Tiwari ◽  
Nabilah I. Chowdhury ◽  
Eva J. Brandl ◽  
Sajid A. Shaikh ◽  
...  
Keyword(s):  
Weight Gain ◽  
Association Study ◽  
Gene Variants ◽  
Receptor Subunit ◽  
Subunit Gene

Association Study of GABAA α2 Receptor Subunit Gene Variants in Antipsychotic-Associated Weight Gain

2015 ◽  
Vol 35 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Clement C.H. Zai ◽  
Arun K. Tiwari ◽  
Nabilah I. Chowdhury ◽  
Eva J. Brandl ◽  
Sajid A. Shaikh ◽  
...  
Keyword(s):  
Weight Gain ◽  
Association Study ◽  
Gene Variants ◽  
Receptor Subunit ◽  
Subunit Gene

GABAA Receptor Subunit Gene Expression in Human Prefrontal Cortex: Comparison of Schizophrenics and Controls

1995 ◽  
Vol 5 (6) ◽  
pp. 550-560 ◽  
Author(s):  
Schahram Akbarian ◽  
Molly M. Huntsman ◽  
James J. Kim ◽  
Alireza Tafazzoli ◽  
Steven G. Potkin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Gabaa Receptor ◽  
Receptor Subunit ◽  
Subunit Gene

scholarly journals Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors

1996 ◽  
Vol 317 (2) ◽  
pp. 419-423 ◽  
Author(s):  
Nathaniel G. N. MILTON ◽  
Alain BESSIS ◽  
Jean-Pierre CHANGEUX ◽  
David S. LATCHMAN
Keyword(s):  
Transcription Factors ◽  
Regulatory Region ◽  
Differential Regulation ◽  
Gene Promoters ◽  
The Novel ◽  
Receptor Subunit ◽  
Subunit Gene ◽  
Related Factors ◽  
Nicotinic Acetylcholine ◽  
Stimulation Of

The regulatory region of the neuronal nicotinic acetylcholine (nACh) receptor α2 subunit gene is activated by the Brn-3b POU family transcription factor but not by the closely related factors Brn-3a and Brn-3c. This pattern of regulation has not previously been observed for other neuronally expressed genes, several of which, such as those encoding α-internexin or SNAP-25, are activated by Brn-3a and Brn-3c but repressed by Brn-3b. The α3 nACh receptor subunit gene is also shown to be activated by Brn-3a but is repressed by Brn-3b and Brn-3c. In contrast, the Brn-3 POU family transcription factors have no effects on either the α7 or β4 nACh receptor subunit genes. The actions of Brn-3b on the α2 subunit are thus in contrast to the inhibitory actions of Brn-3b on several promoters that are activated by Brn-3a. The different actions of the Brn-3 POU factors on the range of nACh receptor genes tested suggests that the novel stimulation of the α2 subunit by Brn-3b is specific to this subunit and not a general feature of nACh receptor genes.

NTRK2 (TrkB gene) variants and temporal lobe epilepsy: A genetic association study

2017 ◽  
Vol 137 ◽  
pp. 1-8 ◽  
Author(s):  
Carolina Machado Torres ◽  
Marina Siebert ◽  
Hugo Bock ◽  
Suelen Mandelli Mota ◽  
Bárbara Reis Krammer ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Association Study ◽  
Genetic Association ◽  
Temporal Lobe ◽  
Genetic Association Study ◽  
Gene Variants

scholarly journals Modifications in Gamma-aminobutyric Acid type A Receptor Subunit Gene Expression During Macrophage Differentiation and Propofol Administration in THP-1 Cells

2021 ◽  
Author(s):  
Tsukasa Kochiyama ◽  
Izumi Kawagoe ◽  
Ai Yamaguchi ◽  
Masataka Fukuda ◽  
Masakazu Hayashida
Keyword(s):  
Gene Expression ◽  
Immune Cells ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Subunit Gene ◽  
Macrophage Differentiation ◽  
Anesthetic Agents ◽  
Acid Type

Abstract Background: Gamma-aminobutyric acid type A (GABAA) receptors are thought to play a role in the functioning of the immune system. GABAA receptors have 19 types of subunits, the components of which determine their physiological functions. However, the subunits that are expressed in immune cells during inflammation have not been fully investigated. Recent reports have shown that anesthetic agents may affect the gene expression of GABAA receptors subunits in immune cells. Therefore, we aimed to investigate the changes in GABAA receptor subunit gene expression during macrophage differentiation and propofol administration in order to clarify the relationship between the expression of GABAA receptors and the immunomodulatory effect of propofol.Methods: Human acute monocytic leukemia (THP-1) cells were differentiated into macrophage-like cells (M0 THP-1); subsequently, M0 THP-1 cells were differentiated into inflammatory M1 macrophage-like cells (M1 THP-1). Propofol was administered during the differentiation into M1 THP-1 cells. Using reverse transcriptase polymerase chain reaction, we examined which GABAA receptor subunit genes were expressed and whether there were changes in the gene expression during macrophage differentiation and propofol administration in THP-1 cells.Results: The expression of the α1, α4, β1, β2, γ1, and γ2 subunits increased during differentiation into M0 THP-1 cells. The expression of the α1, α4, β1, β2, γ2, and δ subunits decreased and that of the γ1 subunit increased during differentiation into M1 THP-1 cells. The gene expression of the α1, α4, and β2 subunits increased upon administering propofol during differentiation into M1 THP-1 cells.Conclusions: The gene expression of GABAA receptor subunits changed during macrophage differentiation in THP-1 cells. The expressions of α1 and α4 increased following propofol administration during the differentiation into M1 THP-1 cells, which may indicate that the GABAA receptor is involved in the immunosuppressive effects of propofol. This study can help in the choice of anesthetic agents for proinflammatory conditions such as highly-invasive surgery.

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