scholarly journals Perianal Pagetoid Intraepithelial Carcinoma

2017 ◽  
Vol 11 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Suanga Sisodia ◽  
Robin Boushey ◽  
Goo Lee ◽  
Celia Marginean ◽  
Marcio M. Gomes ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Surgical Management ◽  
Colorectal Tumor ◽  
Perianal Region ◽  
Paget Disease ◽  
Primary Colorectal Tumor ◽  
Intraepithelial Carcinoma

Extramammary Paget disease (EMPD) involving the perianal region is rare and challenging to manage. Primary EMPD involves stand-alone noninvasive lesions within the epidermis, while secondary EMPD involves phenotypically similar lesions derived from separate underlying malignancies. Differentiating between primary and secondary EMPD is challenging when no underlying malignancies are detected during workup. Continued reporting of perianal EMPD cases is encouraged so that risk stratification can be improved and patients can be managed with an appropriate level of aggressiveness. Herein, we report the case of a 74-year-old woman who chose aggressive surgical management after being diagnosed with perianal pagetoid intraepithelial carcinoma from a suspected occult underlying primary colorectal tumor.

scholarly journals Discordance of KRAS Mutational Status between Primary Tumors and Liver Metastases in Colorectal Cancer: Impact on Long-Term Survival Following Radical Resection

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2148
Author(s):  
Francesco Ardito ◽  
Francesco Razionale ◽  
Lisa Salvatore ◽  
Tonia Cenci ◽  
Maria Vellone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Primary Tumor ◽  
Kras Mutation ◽  
Colorectal Tumor ◽  
Term Survival ◽  
Primary Tumors ◽  
Mutation Status ◽  
Primary Colorectal Tumor ◽  
Kras Mutation Status

If KRAS mutation status of primary colorectal tumor is representative of corresponding colorectal liver metastases (CRLM) mutational pattern, is controversial. Several studies have reported different rates of KRAS discordance, ranging from 4 to 32%. Aim of this study is to assess the incidence of discordance and its impact on overall survival (OS) in a homogenous group of patients. KRAS mutation status was evaluated in 107 patients resected for both primary colorectal tumor and corresponding CRLM at the same institution, between 2007 and 2018. Discordance rate was 15.9%. Its incidence varied according to the time interval between the two mutation analyses (p = 0.025; Pearson correlation = 0.2) and it was significantly higher during the first 6 months from the time of primary tumor evaluation. On multivariable analysis, type of discordance (wild-type in primary tumor, mutation in CRLM) was the strongest predictor of poor OS (p < 0.001). At multivariable logistic regression analysis, the number of CRLM >3 was an independent risk factor for the risk of KRAS discordance associated with the worst prognosis (OR = 4.600; p = 0.047). Results of our study suggested that, in the era of precision medicine, possibility of KRAS discordance should be taken into account within multidisciplinary management of patients with metastatic colorectal cancer.

Risk stratification of sentinel node–positive melanoma patients defines surgical management and adjuvant therapy treatment considerations

2018 ◽  
Vol 96 ◽  
pp. 25-33 ◽  
Author(s):  
Daniëlle Verver ◽  
David van Klaveren ◽  
Alexander C.J. van Akkooi ◽  
Piotr Rutkowski ◽  
Barry W.E.M. Powell ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Risk Stratification ◽  
Sentinel Node ◽  
Surgical Management ◽  
Node Positive ◽  
Treatment Considerations ◽  
Melanoma Patients ◽  
Therapy Treatment

Metastatic Extramammary Paget Disease of the Perianal Region

2019 ◽  
Vol 44 (7) ◽  
pp. e431-e432
Author(s):  
Anitha Mandava ◽  
Veeraiah Koppula ◽  
Rohit Yalamanchili ◽  
Zakir Ali
Keyword(s):  
Perianal Region ◽  
Paget Disease

F-18 FDG PET/CT Imaging of Extramammary Paget Disease of the Perianal Region

2006 ◽  
Vol 31 (9) ◽  
pp. 561-563 ◽  
Author(s):  
Ryan D. Niederkohr ◽  
Sanjiv S. Gambhir
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Perianal Region ◽  
Paget Disease ◽  
Pet Ct ◽  
Fdg Pet Ct
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