Micronutrients and Drug Response: Vitamin A and Vitamin E in the Fetus and in the Newborn

1990 ◽  
Vol 15 (3-4) ◽  
pp. 166-172 ◽  
Author(s):  
Rafael Gorodischer
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Drug Response

scholarly journals Vitamin A and E Homologues Impacting the Fate of Acrylamide in Equimolar Asparagine-Glucose Model System

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 993
Author(s):  
Su Lee Kuek ◽  
Azmil Haizam Ahmad Tarmizi ◽  
Raznim Arni Abd Razak ◽  
Selamat Jinap ◽  
Maimunah Sanny
Keyword(s):  
Vitamin E ◽  
Linear Regression ◽  
Vitamin A ◽  
Regression Model ◽  
Linear Regression Model ◽  
Model System ◽  
Concentration Increase ◽  
Acrylamide Formation ◽  
Β Carotene

This study aims to evaluate the influence of Vitamin A and E homologues toward acrylamide in equimolar asparagine-glucose model system. Vitamin A homologue as β-carotene (BC) and five Vitamin E homologues, i.e., α-tocopherol (AT), δ-tocopherol (DT), α-tocotrienol (ATT), γ-tocotrienol (GTT), and δ-tocotrienol (DTT), were tested at different concentrations (1 and 10 µmol) and subjected to heating at 160 °C for 20 min before acrylamide quantification. At lower concentrations (1 µmol; 431, 403, 411 ppm, respectively), AT, DT, and GTT significantly increase acrylamide. Except for DT, enhancing concentration to 10 µmol (5370, 4310, 4250, 3970, and 4110 ppm, respectively) caused significant acrylamide formation. From linear regression model, acrylamide concentration demonstrated significant depreciation over concentration increase in AT (Beta = −83.0, R2 = 0.652, p ≤ 0.05) and DT (Beta = −71.6, R2 = 0.930, p ≤ 0.05). This study indicates that different Vitamin A and E homologue concentrations could determine their functionality either as antioxidants or pro-oxidants.

scholarly journals CFTR Modulator Therapy with Lumacaftor/Ivacaftor Alters Plasma Concentrations of Lipid-Soluble Vitamins A and E in Patients with Cystic Fibrosis

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 483
Author(s):  
Olaf Sommerburg ◽  
Susanne Hämmerling ◽  
S. Philipp Schneider ◽  
Jürgen Okun ◽  
Claus-Dieter Langhans ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Vitamin A ◽  
Clinical Chemistry ◽  
Pancreatic Insufficiency ◽  
Plasma Concentrations ◽  
Plasma Vitamin ◽  
Hypervitaminosis A ◽  
Cholesterol Ratio ◽  
Fat Soluble Vitamins

Rationale: Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leads to impaired pancreatic function and therefore reduced intestinal absorption of lipids and fat-soluble vitamins especially in patients with CF developing pancreatic insufficiency (PI). Previous studies showed that CFTR modulator therapy with lumacaftor-ivacaftor (LUM/IVA) in Phe508del-homozygous patients with CF results in improvement of pulmonary disease and thriving. However, the effects of LUM/IVA on plasma concentration of the lipid soluble vitamins A and E remain unknown. Objectives: To investigate the course of plasma vitamin A and E in patients with CF under LUM/IVA therapy. Methods: Data from annual follow-up examinations of patients with CF were obtained to assess clinical outcomes including pulmonary function status, body mass index (BMI), and clinical chemistry as well as fat-soluble vitamins in Phe508del-homozygous CF patients before initiation and during LUM/IVA therapy. Results: Patients with CF receiving LUM/IVA improved substantially, including improvement in pulmonary inflammation, associated with a decrease in blood immunoglobulin G (IgG) from 9.4 to 8.2 g/L after two years (p < 0.001). During the same time, plasma vitamin A increased significantly from 1.2 to 1.6 µmol/L (p < 0.05), however, levels above the upper limit of normal were not detected in any of the patients. In contrast, plasma vitamin E as vitamin E/cholesterol ratio decreased moderately over the same time from 6.2 to 5.5 µmol/L (p < 0.01). Conclusions: CFTR modulator therapy with LUM/IVA alters concentrations of vitamins A and vitamin E in plasma. The increase of vitamin A must be monitored critically to avoid hypervitaminosis A in patients with CF.

Cane toad ( Rhinella marina ) vitamin A, vitamin E, and carotenoid kinetics

Zoo Biology ◽  
2021 ◽  
Author(s):  
Tarra Freel ◽  
Elizabeth Koutsos ◽  
Larry J. Minter ◽  
Troy Tollefson ◽  
Frank Ridgley ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Cane Toad ◽  
Rhinella Marina

Synergistic Interactions between Vitamin A and Vitamin E against Lipid Peroxidation in Phosphatidylcholine Liposomes

1996 ◽  
Vol 326 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Luisa Tesoriere ◽  
Antonino Bongiorno ◽  
Anna Maria Pintaudi ◽  
Rossella D'Anna ◽  
Daniele D'Arpa ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Vitamin A ◽  
Phosphatidylcholine Liposomes ◽  
Synergistic Interactions

scholarly journals Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

2018 ◽  
Vol 7 ◽  
Author(s):  
Corrine Hanson ◽  
Marina Verdi Schumacher ◽  
Elizabeth Lyden ◽  
Dejun Su ◽  
Jeremy Furtado ◽  
...  
Keyword(s):  
Public Health ◽  
Health Disparities ◽  
Food Security ◽  
Health Insurance ◽  
Vitamin E ◽  
Vitamin A ◽  
Serum Levels ◽  
Food Desert ◽  
Health Concern ◽  
Lower Serum

AbstractThe objective of the present study was to evaluate intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal–infant pairs in the Midwestern USA in relation to measures of health disparities. Concentrations of carotenoids and tocopherols in maternal serum were measured using HPLC and measures of socio-economic status, including food security and food desert residence, were obtained in 180 mothers upon admission to a Midwestern Academic Medical Center labour and delivery unit. The Kruskal–Wallis and independent-samples t tests were used to compare measures between groups; logistic regression models were used to adjust for relevant confounders. P < 0·05 was considered statistically significant. The odds of vitamin A insufficiency/deficiency were 2·17 times higher for non-whites when compared with whites (95 % CI 1·16, 4·05; P = 0·01) after adjustment for relevant confounders. Similarly, the odds of being vitamin E deficient were 3·52 times higher for non-whites (95 % CI 1·51, 8·10; P = 0·003). Those with public health insurance had lower serum lutein concentrations compared with those with private health insurance (P = 0·05), and living in a food desert was associated with lower serum concentrations of β-carotene (P = 0·02), after adjustment for confounders. Subjects with low/marginal food security had higher serum levels of lutein and β-cryptoxanthin compared with those with high food security (P = 0·004 and 0·02 for lutein and β-cryptoxanthin). Diet quality may be a public health concern in economically disadvantaged populations of industrialised societies leading to nutritional disadvantages as well.

Assay for Vitamins D2 and D3 in the Presence of Tocopherols (Vitamin E) and Vitamin A

1971 ◽  
Vol 60 (6) ◽  
pp. 913-916 ◽  
Author(s):  
D.K. Feeter ◽  
M.F. Jacobs ◽  
H.W. Rawlings
Keyword(s):  
Vitamin E ◽  
Vitamin A

scholarly journals Effects of Various Lipid-like Additives on Vitamin A and Vitamin E Contents of Egg Yolk Composition

1985 ◽  
Vol 56 (5) ◽  
pp. 414-416
Author(s):  
Tutomu KONNO ◽  
Tadatoshi ASADA ◽  
Tatuo KATUO
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Egg Yolk
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