Role of Alpha-1-Fetoprotein in the Transplacental Transfer of Natural and Synthetic Estrogens in the Rat

1982 ◽  
Vol 4 (S1) ◽  
pp. 79-87 ◽  
Author(s):  
Annie Le Guern ◽  
Claudine Benassayag ◽  
E.A. Nunez
Keyword(s):  
Transplacental Transfer ◽  
Synthetic Estrogens ◽  
Natural And Synthetic

PI3K/ Akt/ mTOR Pathway as a Therapeutic Target for Colorectal Cancer: A Review of Preclinical and Clinical Evidence

2019 ◽  
Vol 20 (12) ◽  
pp. 1217-1226 ◽  
Author(s):  
Arunaksharan Narayanankutty
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Therapeutic Target ◽  
Clinical Evidence ◽  
Mtor Pathway ◽  
Colorectal Cancers ◽  
Patent Literature ◽  
Mtor Signalling ◽  
Natural And Synthetic

Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases and involved in the regulation of cellular proliferation, differentiation and survival. Overexpression of the PI3K/Akt/mTOR signalling has been reported in various forms of cancers, especially in colorectal cancers (CRC). Due to their significant roles in the initiation and progression events of colorectal cancer, they are recognized as a striking therapeutic target. Objective: The present review is aimed to provide a detailed outline on the role of PI3K/Akt/mTOR pathway in the initiation and progression events of colorectal cancers as well as its function in drug resistance. Further, the role of PI3K/Akt/mTOR inhibitors alone and in combination with other chemotherapeutic drugs, in alleviating colorectal cancer is also discussed. The review contains preclinical and clinical evidence as well as patent literature of the pathway inhibitors which are natural and synthetic in origin. Methods: The data were obtained from PubMed/Medline databases, Scopus and Google patent literature. Results: PI3K/Akt/mTOR signalling is an important event in colorectal carcinogenesis. In addition, it plays significant roles in acquiring drug resistance as well as metastatic initiation events of CRCs. Several small molecules of natural and synthetic origin have been found to be potent inhibitors of CRCs by effectively downregulating the pathway. Data from various clinical studies also support these pathway inhibitors and several among them are patented. Conclusion: Inhibitors of the PI3K/mTOR pathway have been successful for the treatment of primary and metastatic colorectal cancers, rendering the pathway as a promising clinical cancer therapeutic target.

New trends in the pharmacological intervention of PPARs in obesity: Role of natural and synthetic compounds_

2020 ◽  
Vol 28 ◽  
Author(s):  
Seyed Mohammad Nabavi ◽  
Kasi Pandima Devi ◽  
Sethuraman Sathya ◽  
Ana Sanches-Silva ◽  
Listos Joanna ◽  
...  
Keyword(s):  
Tissue Expression ◽  
Health Concern ◽  
Pharmacological Intervention ◽  
Peroxisome Proliferator ◽  
Expression Of Genes ◽  
Ppar Agonists ◽  
Prevalence Of Obesity ◽  
Peroxisome Proliferator Activated Receptors ◽  
Natural And Synthetic

: Obesity is a major health concern for a growing fraction of the population, with the prevalence of obesity and its related metabolic disorders not being fully understood. Over the last decade, many attempts have been undertaken to understand the mechanisms at the basis of this condition, in which the accumulation of fat occurring in adipose tissue, leads to the pathogenesis of obesity related disorders. Among the most recent studies, those on Peroxisome Proliferator Activated Receptors (PPARs) revealed that these nuclear receptor proteins acting as transcription factors, among others, regulate the expression of genes involved in energy, lipid, and glucose metabolisms, and chronic inflammation. The three different isotypes of PPARs, with different tissue expression and ligand binding specificity, exert similar or overlapping functions directly or indirectly linked to obesity. In this study, we reviewed the available scientific reports concerning the PPARs structure and functions, especially in obesity, considering both natural and synthetic ligands and their role in the therapy of obesity and obesity-associated disorders. In the whole, the collected data show that there are both natural and synthetic compounds that show beneficial promising activity as PPAR agonists in chronic diseases related to obesity.

Opportunities and Challenges for Sustainable Bioremediation of Natural and Synthetic Estrogens as Emerging Water Contaminants Using Bacteria, Fungi, and Algae

2021 ◽  
Vol 232 (6) ◽  
Author(s):  
Anisa Ratnasari ◽  
Achmad Syafiuddin ◽  
Ahmad Beng Hong Kueh ◽  
Suhartono Suhartono ◽  
Tony Hadibarata
Keyword(s):  
Water Contaminants ◽  
Synthetic Estrogens ◽  
Natural And Synthetic

Role of cyclic voltammetry in characterizing solids: natural and synthetic manganese oxide octahedral molecular sieves

1993 ◽  
Vol 5 (10) ◽  
pp. 1395-1400 ◽  
Author(s):  
Roberto N. De Guzman ◽  
Yan Fei Shen ◽  
Brenda R. Shaw ◽  
Steven L. Suib ◽  
Chi Lin O'Young
Keyword(s):  
Cyclic Voltammetry ◽  
Manganese Oxide ◽  
Molecular Sieves ◽  
Octahedral Molecular Sieves ◽  
Natural And Synthetic

Role of strain rate in the strain-induced crystallization (SIC) of natural and synthetic isoprene rubber

2018 ◽  
Vol 51 (2) ◽  
pp. 221-226 ◽  
Author(s):  
Yuji Kitamura ◽  
Kiyoka Okada ◽  
Hiroyasu Masunaga ◽  
Masamichi Hikosaka
Keyword(s):  
Strain Rate ◽  
Strain Induced Crystallization ◽  
Induced Crystallization ◽  
Isoprene Rubber ◽  
Natural And Synthetic

Role of calcium looping conditions on the performance of natural and synthetic Ca-based materials for energy storage

2018 ◽  
Vol 28 ◽  
pp. 374-384 ◽  
Author(s):  
Beatriz Sarrión ◽  
Antonio Perejón ◽  
Pedro E. Sánchez-Jiménez ◽  
Luis A. Pérez-Maqueda ◽  
José Manuel Valverde
Keyword(s):  
Energy Storage ◽  
Calcium Looping ◽  
Natural And Synthetic

Role of P-glycoprotein in transplacental transfer of methadone

2003 ◽  
Vol 189 (6) ◽  
pp. S124 ◽  
Author(s):  
Tatiana Nanovskaya ◽  
Ilona Nekhayeva ◽  
Olga Zharikova ◽  
Gary Hankins ◽  
Mahmoud Ahmed
Keyword(s):  
Transplacental Transfer ◽  
P Glycoprotein

Catabolism of organophosphonates: biochemistry, physiology and interactions of degrading bacteria in the environment

2020 ◽  
pp. 253-287 ◽  
Author(s):  
Inna Ermakova ◽  
Alexey Leontievsky ◽  
Alexey Sviridov ◽  
Tatyana Shushkova ◽  
Dmitriy Epiktetov
Keyword(s):  
Significant Role ◽  
Physiological Role ◽  
Phosphorus Compounds ◽  
Enzyme Systems ◽  
Degrading Bacteria ◽  
Structure Diversity ◽  
Anthropogenic Ecosystems ◽  
Natural And Synthetic

The major contribution of microorganisms in metabolism of natural and synthetic phosphonates, the biochemical bases of these processes and possible interactions between degrading bacteria in natural and anthropogenic ecosystems are presented in the light of the recent data on significant role of reduced phosphorus compounds in the biosphere. Special emphasis is placed on C-P lyase and phosphonatase which are pivotal enzyme systems for catabolism of both natural and synthetic phosphonates. Modern data on structure, diversity, regulation and physiological role of both enzymes are reviewed and discussed.

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