Effect of Short-Term Ischemic Trauma on the Hepatic Cytochrome P-450 Monooxygenase System in the Neonatal Rat

1983 ◽  
Vol 6 (1) ◽  
pp. 64-72
Author(s):  
Julia D. George ◽  
Gerald M. Rosen ◽  
Elmer J. Rauckman
Keyword(s):  
Neonatal Rat ◽  
Monooxygenase System ◽  
Short Term ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

scholarly journals Effects of Bromocriptine on Hepatic Cytochrome P-450 Monooxygenase System

1989 ◽  
Vol 49 (2) ◽  
pp. 285-291
Author(s):  
Shabbir M. MOOCHHALA ◽  
Edmund J.D. LEE ◽  
Gwendolene T.M. HU ◽  
O.S. KOH ◽  
Gordon BECKET
Keyword(s):  
Monooxygenase System ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

scholarly journals Effects of bromocriptine on hepatic cytochrome P-450 monooxygenase system.

1989 ◽  
Vol 49 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Shabbir M. MOOCHHALA ◽  
Edmund J.D. LEE ◽  
Gwendolene T.M. HU ◽  
O.S. KOH ◽  
Gordon BECKET
Keyword(s):  
Monooxygenase System ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

scholarly journals Cyclization reactions of IMM-125 and oxidation of cyclosporin A amino-acid 1 in theαposition of the double bond lead to the loss ofin vitroimmunosuppressive activity

2000 ◽  
Vol 14 (4) ◽  
pp. 215-228
Author(s):  
R. Dieden ◽  
D. Latinne ◽  
C. Baldari ◽  
N. Maton ◽  
A. Aubry ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cyclosporin A ◽  
Parent Drug ◽  
Nucleophilic Attack ◽  
Monooxygenase System ◽  
Cyclization Reactions ◽  
Perbenzoic Acid ◽  
Jurkat T Cell ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

Cyclosporin A (CsA) and IMM-125, a hydroxyethyl derivative of D-serine CsA, are cyclic undecapeptides of molecular weight 1201.8 and 1261.8, respectively. The main metabolites still possessing the undecapeptide structure were found to be compounds resulting from the biotransformation of amino acids 4, 9 and 1.Under the influence of the hepatic cytochrome P-450-dependent monooxygenase system, CsA and IMM-125 amino acid 1 are metabolized to a mono-hydroxylated compound (metabolite M-17) and to a dihydrodiol. A metabolite M18 was found to be the result of a non-enzymic intramolecular formation of a tetrahydrofuran derivative from metabolite M17. Since the existence of a CsA dihydrodiol was reported and since epoxides are considered as the dihydrodiol precursors, the aim of the present work was to prove that the same non-enzymic intramolecular formation of a tetrahydrofuran ring could occur by nucleophilic attack of the amino-acid 1β-hydroxy group at theɛ-position of the freshly formed epoxide by reaction of IMM-125 with m-chloro-perbenzoic acid and cyclosporin A with selenium oxide. The immunosuppressive activity of the compounds, as measured by the mixed lymphocyte reaction and by the luciferase activity of a Jurkat-T-cell line stably transfected with the NF-AT/luc reporter plasmid, was found negligible for IMM-125 compared to the parent drug as well as for the cyclosporin A derivative. Structures of the IMM-125 and CsA derivatives were elucidated by electrospray mass‒spectrometry and NMR spectroscopy.

scholarly journals Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment

1979 ◽  
Vol 182 (1) ◽  
pp. 233-235 ◽  
Author(s):  
J E A Leakey ◽  
J R Fouts
Keyword(s):  
Rat Liver ◽  
Neonatal Rat ◽  
Adult Liver ◽  
Glucocorticoid Treatment ◽  
Early Postnatal Development ◽  
Liver Cytochrome ◽  
Foetal Rat ◽  
Cytochrome P 450 ◽  
Precocious Development ◽  
Hepatic Cytochrome

Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the ‘trigger’ initiating onset of that development.

Sign in / Sign up

Export Citation Format

Share Document