Evaluating Birth Frequencies and Embryonic Lethality in Transgenesis Following Pronuclear Injection of HIV DNA

1995 ◽  
Vol 2 (2) ◽  
pp. 146-153
Author(s):  
Peter Dickie
Keyword(s):  
Embryonic Lethality ◽  
Hiv Dna ◽  
Pronuclear Injection

HIV DNA and Immune Alteration During Successful HAART

2013 ◽  
Vol 11 (4) ◽  
pp. 255-262 ◽  
Author(s):  
Diallo Mamadou ◽  
Zheng Yu-Huang ◽  
Chen Xia ◽  
He Bo ◽  
Zhou Hua-Ying ◽  
...  
Keyword(s):  
Immune Alteration ◽  
Hiv Dna

scholarly journals The Drosophila engrailed and invected Genes: Partners in Regulation, Expression and Function

Genetics ◽  
1996 ◽  
Vol 142 (3) ◽  
pp. 893-906 ◽  
Author(s):  
Elizabeth Gustavson ◽  
Andrew S Goldsborough ◽  
Zehra Ali ◽  
Thomas B Kornberg
Keyword(s):  
Expression Pattern ◽  
Cultured Cells ◽  
Regulatory Region ◽  
Embryonic Lethality ◽  
Wild Type ◽  
Terminal Portion ◽  
Coding Sequence ◽  
Differential Effects ◽  
And Function ◽  
Redundant Functions

Abstract We isolated and characterized numerous engrailed and invected alleles. Among the deficiencies we isolated, a mutant lacking invected sequences was viable and phenotypically normal, a mutant lacking engrailed was an embryo lethal and had slight segmentation defects, and a mutant lacking both engrailed and invected was most severely affected. In seven engrailed alleles, mutations caused translation to terminate prematurely in the central or C-terminal portion of the coding sequence, resulting in embryonic lethality and segmentation defects. Both engrailed and invected expression declined prematurely in these mutant embryos. In wild-type embryos, engrailed and invected are juxtaposed and are expressed in essentially identical patterns. A breakpoint mutant that separates the mgrailed and invected transcription units parceled different aspects of the expression pattern to engrailed or invected. We also found that both genes cause similar defects when expressed ectopically and that the protein products of both genes act to repress transcription in cultured cells. We propose that the varied phenotypes of the engrailed alleles can be explained by the differential effects these mutants have on the combination of engrailed and invected activities, that engrailed and invected share a regulatory region, and that they encode redundant functions.

Single-Particle Electrochemical Biosensor with DNA Walker Amplification for Ultrasensitive HIV-DNA Counting

2021 ◽  
Vol 93 (10) ◽  
pp. 4506-4512
Author(s):  
Fanwei Luo ◽  
Fei Chen ◽  
Yi Xiong ◽  
Zhen Wu ◽  
Xiuhua Zhang ◽  
...  
Keyword(s):  
Single Particle ◽  
Electrochemical Biosensor ◽  
Hiv Dna ◽  
Dna Walker
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