New Insights into the Structure and Function of the Thyroid Hormone Receptor

1995 ◽  
Vol 2 (2) ◽  
pp. 77-89
Author(s):  
Sheue-Yann Cheng
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Structure And Function ◽  
And Function

scholarly journals Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)

2019 ◽  
Author(s):  
Ciana Deveau ◽  
Xiaodong Jiao ◽  
Sachihiro Suzuki ◽  
Asha Krishnakumar ◽  
Takeshi Yoshimatsu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Retinal Development ◽  
Functional Changes ◽  
Binding Domains ◽  
Morphological Findings ◽  
Cone Sensitivity ◽  
And Function

AbstractWe investigate a splice variant of thrb isolated in the retina, trβ2, identifying functional changes in larval and adult mutant zebrafish lacking trβ2. We constructed two CRISPR mutant zebrafish with mutations located in the N-terminus region. The first is a 6BP+1 insertion deletion frameshift resulting in a truncated protein. The second is a 3BP in frame deletion with intact binding domains. ERG recordings showed that the 6BP+1 mutants did not respond to red wavelengths of light while the 3BP mutants did respond. 6BP+1 mutants lacked optomotor and optokinetic responses to red/black and green/black contrasts. Adult 6BP+1 mutants exhibit a loss of red-cone contribution to the ERG, and an increase in green and UV contributions. Anatomical markers show loss of red-cones in the 6BP+1 mutant but increase in blue, green, and UV cone density. Our results confirm trβ2’s role in retinal cone development.Author SummaryThere are four cone photoreceptors responsible for color vision in zebrafish: red, green, blue, and UV. The thyroid hormone receptor trβ2 is localized in the vertebrate retina. We know that it is necessary for the development of long-wavelength-sensitive cones (red), but here we investigate the functional alterations that accompany a loss of trβ2. Our work contributes to the ongoing investigations of retinal development and the involvement of thyroid hormone receptors. Confirming previous morphological findings, we see that the fish become red colorblind when trβ2 is knocked out, but the contributions of the other three cone types shift in response. Our work highlights the plasticity of the retinal circuit as we see changes in opsin peaks and cone sensitivity, increases in contributions of UV cones, and an attempt at a mosaic pattern in the adult retina all in the absence of trβ2 and red cones. We now have an increased understanding of mechanisms underlying retinal development

scholarly journals Cardiac Expression and Function of Thyroid Hormone Receptor β and Its PV Mutant

Endocrinology ◽  
2003 ◽  
Vol 144 (11) ◽  
pp. 4820-4825 ◽  
Author(s):  
Eric A. Swanson ◽  
Bernd Gloss ◽  
Darrell D. Belke ◽  
Masahiro Kaneshige ◽  
Sheue-Yann Cheng ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
And Function ◽  
Thyroid Hormone Receptor Β

scholarly journals Expression and function of thyroid hormone receptor variants in normal and chronically diseased human liver.

1996 ◽  
Vol 81 (1) ◽  
pp. 360-367
Author(s):  
A Chamba ◽  
J Neuberger ◽  
A Strain ◽  
J Hopkins ◽  
M C Sheppard ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Human Liver ◽  
Thyroid Hormone Receptor ◽  
And Function

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

2018 ◽  
Vol 11 (536) ◽  
pp. eaam5855 ◽  
Author(s):  
Brijesh K. Singh ◽  
Rohit A. Sinha ◽  
Madhulika Tripathi ◽  
Arturo Mendoza ◽  
Kenji Ohba ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Mitochondrial Fission ◽  
And Function
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