scholarly journals The Development of Sayk's Cell Sedimentation Chamber: A Historical View on Clinical Cerebrospinal Fluid Diagnostics

2017 ◽  
Vol 77 (3-4) ◽  
pp. 162-167 ◽  
Author(s):  
Nathalie Dahlmann ◽  
Uwe K. Zettl ◽  
Ekkehardt Kumbier
Keyword(s):  
Cerebrospinal Fluid ◽  
Historical View ◽  
Cerebrospinal Fluid Diagnostics

Cerebrospinal fluid diagnostics in first-episode schizophrenia

2011 ◽  
Vol 261 (7) ◽  
pp. 529-530 ◽  
Author(s):  
Laura Kranaster ◽  
Dagmar Koethe ◽  
Carolin Hoyer ◽  
Andreas Meyer-Lindenberg ◽  
F. Markus Leweke
Keyword(s):  
Cerebrospinal Fluid ◽  
First Episode ◽  
Cerebrospinal Fluid Diagnostics ◽  
First Episode Schizophrenia

scholarly journals The Influence of Blood Contamination on Cerebrospinal Fluid Diagnostics

2019 ◽  
Vol 10 ◽  
Author(s):  
Philipp Schwenkenbecher ◽  
Theda Janssen ◽  
Ulrich Wurster ◽  
Felix Franz Konen ◽  
Alexandra Neyazi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Contamination ◽  
Cerebrospinal Fluid Diagnostics

scholarly journals Leptomeningeal Metastasis: The Role of Cerebrospinal Fluid Diagnostics

2019 ◽  
Vol 10 ◽  
Author(s):  
Lena Bönig ◽  
Nora Möhn ◽  
Jonas Ahlbrecht ◽  
Ulrich Wurster ◽  
Peter Raab ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Leptomeningeal Metastasis ◽  
Cerebrospinal Fluid Diagnostics

scholarly journals Metabolomics in postmortem cerebrospinal fluid diagnostics: a state-of-the-art method to interpret central nervous system–related pathological processes

2020 ◽  
Vol 135 (1) ◽  
pp. 183-191
Author(s):  
Simone Bohnert ◽  
Christoph Reinert ◽  
Stefanie Trella ◽  
Werner Schmitz ◽  
Benjamin Ondruschka ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Causes Of Death ◽  
State Of The Art ◽  
Metabolite Profile ◽  
Preliminary Assessment ◽  
Biochemical Processes ◽  
Metabolite Profiles ◽  
Cerebrospinal Fluid Diagnostics ◽  
Torso Trauma ◽  
New Generation

AbstractIn the last few years, quantitative analysis of metabolites in body fluids using LC/MS has become an established method in laboratory medicine and toxicology. By preparing metabolite profiles in biological specimens, we are able to understand pathophysiological mechanisms at the biochemical and thus the functional level. An innovative investigative method, which has not yet been used widely in the forensic context, is to use the clinical application of metabolomics. In a metabolomic analysis of 41 samples of postmortem cerebrospinal fluid (CSF) samples divided into cohorts of four different causes of death, namely, cardiovascular fatalities, isoIated torso trauma, traumatic brain injury, and multi-organ failure, we were able to identify relevant differences in the metabolite profile between these individual groups. According to this preliminary assessment, we assume that information on biochemical processes is not gained by differences in the concentration of individual metabolites in CSF, but by a combination of differently distributed metabolites forming the perspective of a new generation of biomarkers for diagnosing (fatal) TBI and associated neuropathological changes in the CNS using CSF samples.

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