Mean Platelet Volume in Heterozygous Beta Thalassaemia

2017 ◽  
Vol 137 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Mehmet Ali Cikrikcioglu ◽  
Kenan Celik ◽  
Iskender Ekinci ◽  
Muharrem Nasifov ◽  
Aybala Erek Toprak ◽  
...  
Keyword(s):  
Platelet Activation ◽  
Mean Platelet Volume ◽  
Linear Regression Analysis ◽  
Serum Levels ◽  
Platelet Volume ◽  
Soluble Cd40 Ligand ◽  
Cross Sectional ◽  
Beta Thalassaemia ◽  
Study Results

Background/Aim: It is not known why cerebrovascular and cardiovascular ischaemic events are less frequently observed in heterozygous beta thalassaemia (HBT) patients than in the general population. However, we previously reported that serum levels of some platelet function markers, i.e. soluble CD40 ligand and soluble P-selectin, are lower in patients with HBT than in controls. A high mean platelet volume (MPV) is an indicator of in vivo platelet activation and may indicate a tendency to thrombosis. We investigated whether MPV is lower in HBT patients than in controls. Methods: Forty-eight patients with HBT were compared with 51 controls matched for gender, age, and BMI for MPV in a cross-sectional study. Results: The MPV was within the normal range and higher in the HBT group (9.64 ± 1.20 vs. 9.07 ± 082 fL, p = 0.006). The 2 groups were similar in terms of atherosclerosis risk factors and medications. After linear regression analysis, the MPV was correlated with HBT, sensitive CRP, and BMI. Conclusion: The higher MPV in patients with HBT could indicate platelet activation, and this may represent a dilemma. Higher MPV in the HBT group might have resulted from higher sympathetic nervous system activity, mild ineffective erythropoiesis, and haemolysis.

scholarly journals Association of low-grade inflammation and platelet activation in patients with hypertension with microalbuminuria

2008 ◽  
Vol 114 (6) ◽  
pp. 449-455 ◽  
Author(s):  
Patrizia Ferroni ◽  
Maria Teresa Guagnano ◽  
Angela Falco ◽  
Vincenzo Paoletti ◽  
Maria Rosaria Manigrasso ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Endothelial Dysfunction ◽  
Platelet Activation ◽  
Protein A ◽  
Multivariate Regression Analysis ◽  
Low Grade ◽  
Soluble Cd40 Ligand ◽  
Cross Sectional ◽  
Low Grade Inflammation

Increased levels of sCD40L (soluble CD40 ligand) have been associated with enhanced in vivo platelet activation, and may represent a molecular link between inflammation and a prothrombotic state. The aim of the present study was to analyse the relationship between platelet activation, endothelial dysfunction, low-grade inflammation and sCD40L in patients with hypertension with or without MA (microalbuminuria). A cross-sectional comparison of sCD40L levels was performed in 25 patients with MH (essential hypertension with MA) pair-matched for gender and age with 25 patients with EH (essential hypertension) and 25 HS (healthy subjects with normotension). Circulating levels of CRP (C-reactive protein), a marker of inflammation, sP-selectin (soluble P-selectin), a marker of in vivo platelet activation, and ADMA (asymmetric dimethylarginine) and vWF (von Willebrand factor), markers of endothelial dysfunction, were analysed in each subject. sCD40L levels were increased in patients with MH compared with either patients with EH (P<0.001) or HS (P<0.0001). A highly significant correlation between plasma sCD40L and sP-selectin (P<0.0001), vWF (P<0.001) or CRP levels (P<0.05) was observed in patients with MH. Multivariate regression analysis showed that sP-selectin was the strongest independent predictor of sCD40L levels (P<0.0001) in patients with MH. Patients with hypertension with both vWF and CRP levels above the median had the highest sCD40L levels (P<0.0001). Factorial ANOVA of all of the patients with hypertension confirmed that only patients with MH with low-grade inflammation had elevated levels of sCD40L. In conclusion, sCD40L levels appear to discriminate a subset of patients characterized by MA and low-grade inflammation, suggesting that inhibition of the CD40/CD40L system may represent a potential therapeutic target in subjects with hypertension at a high risk of cardiovascular events.

scholarly journals HUBUNGAN MEAN PLATELET VOLUME DENGAN HbA1C DAN PROFIL LIPID PADA PENDERITA DIABETES MELITUS

2020 ◽  
Vol 13 (2) ◽  
pp. 73-80
Author(s):  
Rosdiana Mus ◽  
Yeremiah Rubin Camin ◽  
Noortiningsih Noortiningsih
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Diabetes Melitus

Prevalensi Diabetes Melitus (DM) dari tahun ke tahun semakin meningkat. DM adalah ditandai dengan hiperglikemia dan intoleransi glukosa yang terjadi karena kelenjar pankreas tidak dapat memproduksi insulin secara adekuat atau karena tubuh tidak dapat menggunakan insulin yang diproduksi secara efektif atau kedua-duanya. Pada penderita DM, aterosklerosis menyumbang hampir 80% dari semua kematian. Pada penderita DM terjadi disfungsi dari trombosit. Trombosit berperan dalam proses hemostasis dan memiliki peran penting dalam aterosklerosis dan trombosis arteri. Rata-rata Volume trombosit atau dikenal dengan Mean Platelet Volume (MPV) adalah penanda fungsi dan aktivasi trombosit. Penelitian ini bertujuan untuk melihat adanya hubungan antara MPV dengan HbA1C dan profil lipid pada penderita DM. Penelitian ini merupakan penelitian cross sectional terhadap data rekam medik di Rumah Sakit Umum Daerah Pasar Rebo dengan sampel sebanyak 300 pasien. Data diperoleh dari bulan Januari 2014 sampai Desember 2015. Data dianalisis dengan menggunakan bantuan SPSS 22.0 dengan metode uji regresi linear ganda. Hasil uji statistik yang diperoleh menunjukkan tidak terdapat hubungan yang signifikan antara MPV dengan profil lipid dan glukosa pp (p>0,05) tetapi terdapat hubungan yang signifikan antara MPV dengan HbA1C dan glukosa puasa (p<0.05) pada penderita DM.

scholarly journals Oxidative stress and gut-derived lipopolysaccharides in children affected by Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections.

2020 ◽  
Author(s):  
Lorenzo Loffredo ◽  
Alberto Spalice ◽  
Francesca Salvatori ◽  
De Castro Giovanna ◽  
Cristiana Alessia Guido ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Prostaglandin F2α ◽  
Neuropsychiatric Disorders ◽  
Serum Levels ◽  
Multiple Linear Regression Analysis ◽  
Tic Disorders ◽  
Streptococcal Infections ◽  
Cross Sectional

Abstract Background: pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) identifies patients with acute onset of obsessive-compulsive and tic disorders. The objective of this study was to assess NOX2 levels, as well as serum 8-iso-prostaglandin F2α (iso-PGF2α) and lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut of patients with PANDAS. Methods: a cross sectional study was performed to compare serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes and LPS in 60 consecutive subjects, including 30 children affected by PANDAS and 30 controls (CT) matched for age and gender. Serum zonulin was used to assess gut permeability. Results: compared with CT, PANDAS children had higher values of sNOX-2-dp, 8-iso-PGF2-alpha and LPS. Simple linear regression analysis showed that sNOX2-dp was significantly correlated with serum LPS (Rs=0.359; p=0.005), zonulin (Rs=0.444; p<0.001) and iso-PGF2α (Rs=0.704; p<0.001). LPS significantly correlated with serum zonulin (Rs=0.610; p<0.001), and iso-PGF2α (Rs=0.591; p=0.001). A multiple linear regression analysis was performed to define the independent predictors of sNOX-2-dp. Isoprostanes and zonulin emerged as the only independent predictive variables associated with sNOX2-dp (R2=68%). Conclusion: this study provides evidences that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be potentially implicated in the process of neuroinflammation.

Abstract WMP25: Mean Platelet Volume as a Predictor of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Bappaditya Ray ◽  
Lane Tinsley ◽  
Lori K Yearout ◽  
David M Thompson
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Ischemia ◽  
Linear Regression ◽  
Mean Platelet Volume ◽  
Transition Point ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Linear Regression Analysis ◽  
Delayed Cerebral Ischemia ◽  
Platelet Volume ◽  
Rate Of Decline

Introduction: Mean platelet volume (MPV) is a common platelet index that estimates average platelet size. In retrospective cohorts, MPV is reported to be higher, on average, in patients who have experienced acute cardiovascular or cerebrovascular events. Aneurysmal subarachnoid hemorrhage (aSAH) is often associated with increased thrombogenic state due to reactive platelets resulting in delayed cerebral ischemia (DCI). Hypothesis: We assessed whether trends in MPV over the first 21 days after aSAH predicts occurrence of DCI. Methods: The present study enrolled a prospective cohort of 47 patients with aSAH. Clinical (H&H, WFNS) grades and daily MPV was recorded. Patients surviving atleast 7 days following aSAH were included for analysis to determine temporal trend of MPV. Mixed linear regression model was used to compare MPV trends between groups defined by clinical grades of varying severity. Segmented linear regression analysis was performed to identify transition point for patients developing DCI in comparison to those without DCI Results: Average age of cohort was 53.3±13.2 years with 68% women. Thirty-five of the 47 (74.5%) were H&H I-III as compared to 21/47 (44.7%) with WFNS 4-5. Thirty-two patients developed DCI. Baseline MPV was no different (~10.5fL) among patients with different clinical grades. In 32 patients who developed DCI, a transition point at 3 days was identified prior to which MPV increased by 0.13fL/day (95% CI 0.04, 0.23; p=0.0047) followed by a decline of 0.03fL/day (95% CI 0.02, 0.04; p=0.0006). Similar trend was not seen in those without DCI. Rate of decline in MPV were steeper among patients with H&H I-III and WFNS 1-3 as compared to those with H&H IV-V and 4-5 [0.26fL/day; 90% CI 0.004, 0.048, p=0.051 and 0.23fL/day; 90% CI 0.003, 0.042, p=0.06 respectively]. Conclusion: Rise in MPV during the first 3 days after aSAH with DCI followed by a decline indicates release of larger platelets after aSAH and possible association with DCI. Absence of declining trend MPV among higher clinical grade aSAH patients suggests persistence of reactive platelets in circulation.

scholarly journals Serum levels of allopregnanolone, progesterone and testosterone in menstrually-related and postmenopausal migraine: A cross-sectional study

Cephalalgia ◽  
2020 ◽  
Vol 40 (12) ◽  
pp. 1355-1362
Author(s):  
Cecilia Rustichelli ◽  
Elisa Bellei ◽  
Stefania Bergamini ◽  
Emanuela Monari ◽  
Carlo Baraldi ◽  
...  
Keyword(s):  
Linear Regression Analysis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Samples ◽  
Cross Sectional ◽  
Menstrually Related Migraine ◽  
Headache Centre ◽  
Post Menopause ◽  
Novel Strategy ◽  
Post Hoc

Background Reduced blood or cerebrospinal fluid levels of allopregnanolone are involved in menstrual cycle-linked CNS disorders, such as catamenial epilepsy. This condition, like menstrually-related migraine, is characterized by severe, treatment-resistant attacks. We explored whether there were differences in allopregnanolone, progesterone and testosterone serum levels between women with menstrually-related migraine (MM, n = 30) or postmenopausal migraine without aura who had suffered from menstrually-related migraine during their fertile age (PM, n = 30) and non-headache control women in fertile age (FAC, n = 30) or post-menopause (PC, n = 30). Methods Participants were women with migraine afferent to a headache centre; controls were female patients’ acquaintances. Serum samples obtained were analyzed by HPLC-ESI-MS/MS. Results In menstrually-related migraine and postmenopausal migraine groups, allopregnanolone levels were lower than in the respective control groups (fertile age and post-menopause) ( p < 0.001, one-way analysis of variance followed by Tukey-Kramer post-hoc comparison test) while progesterone and testosterone levels were similar. By grouping together patients with migraine, allopregnanolone levels were inversely correlated with the number of years and days of migraine/3 months ( p ≤ 0.005, linear regression analysis). Conclusion Decreased GABAergic inhibition, due to low allopregnanolone serum levels, could contribute to menstrually-related migraine and persistence of migraine after menopause. For the management of these disorders, a rise in the GABAergic transmission by increasing inhibitory neurosteroids might represent a novel strategy.

scholarly journals Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 126 ◽  
Author(s):  
Abidullah Khan ◽  
Iqbal Haider ◽  
Maimoona Ayub ◽  
Salman Khan
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Platelet Volume ◽  
Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study.  On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.    Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001).  Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

scholarly journals Serum Vitamins D, B9 and B12 in Greek Patients with Inflammatory Bowel Diseases

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3734
Author(s):  
Aristea Gioxari ◽  
Charalampia Amerikanou ◽  
Efstathia Papada ◽  
Evangelia Zioga ◽  
Andreas D. Georgoulis ◽  
...  
Keyword(s):  
Disease Activity ◽  
Linear Regression Analysis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Nutritional Intake ◽  
Serum Folate ◽  
Cross Sectional ◽  
Dietary History ◽  
Vitamin Deficiencies ◽  
Inflammatory Bowel

Deficiencies in vitamin D, folate and cobalamin are common in Inflammatory Bowel Disease (IBD). The aim of the present study was to assess serum levels of these vitamins in IBD adults based on the respective serum cut off values for vitamin deficiencies, and to explore possible associations with IBD-related biomarkers and nutritional intake. A cross-sectional study was carried out and patients with Crohn’s disease (CD) or ulcerative colitis (UC) from Attica-Greece were enrolled. Medical and dietary history, clinical examination and blood/stool biomarkers were evaluated. In total, 87 patients participated in the study. Serum levels of 25(OH)D, folate and cobalamin were deficient in 36.8%, 18.4% and 5.7% of patients, respectively. Linear regression analysis in the overall patients showed positive associations between (a) serum 25(OH)D with serum iron (beta = 0.083, p = 0.005) and (b) serum cobalamin with total bilirubin (beta = 0.357, p = 0.020) and direct bilirubin (beta = 0.727, p = 0.033), adjusting for age, sex, body mass index (BMI), disease activity and duration, smoking, nutritional intake and season of recruitment. In CD patients (N = 54), a negative linear association between serum folate and fecal lysozyme was evident (beta = −0.009, p = 0.020). No associations were found for UC patients (N = 33). The serum vitamin profile may be a complementary biomarker for the evaluation of disease activity next to serum and stool inflammatory biomarkers.

scholarly journals Central retinal vein occlusion associated with platelet activation

2019 ◽  
Vol 11 ◽  
pp. 251584141986484 ◽  
Author(s):  
Mehmet Citirik
Keyword(s):  
Retinal Vein Occlusion ◽  
Platelet Activation ◽  
Central Retinal Vein Occlusion ◽  
Mean Platelet Volume ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Platelet Volume ◽  
Distribution Width ◽  
Vein Occlusion ◽  
Central Retinal Vein

Purpose:The aim of this article is to determine and compare the platelet activation by three main platelet activation parameters: mean platelet volume, platelet distribution width, and plateletcrit in patients with central retinal vein occlusion and control subjects.Methods:This study included 30 patients with nonischemic central retinal vein occlusion and 30 control subjects. The levels of mean platelet volume, platelet distribution width, and plateletcrit were measured in all groups.Results:The mean serum level of mean platelet volume was 10.01 ± 0.89 fl in central retinal vein occlusion group and 8.74 ± 1.45 fl in control group. The mean serum level of platelet distribution width was 14.31 ± 1.49% and 11.65 ± 1.81% in central retinal vein occlusion group and control group, respectively. Mean serum plateletcrit value was 0.27 ± 0.07% in central retinal vein occlusion group and 0.23 ± 0.07% in control group. Mean platelet volume, platelet distribution width, and plateletcrit levels were significantly higher in central retinal vein occlusion patients than controls ( p < 0.05).Conclusion:Subclinical platelet activation reflected by mean platelet volume, platelet distribution width, and plateletcrit may have an impact on the genesis of vessel occlusion in central retinal vein occlusion. The results may be important for the clinical management of patients with central retinal vein occlusion.

scholarly journals Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003–2014)

2019 ◽  
Vol 73 (11) ◽  
pp. 1012-1019 ◽  
Author(s):  
Linda Dunder ◽  
Margareta H Lejonklou ◽  
P Monica Lind ◽  
Lars Lind
Keyword(s):  
Bisphenol A ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Epidemiological Studies ◽  
Lipoprotein Cholesterol ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Study Results

BackgroundMounting evidence from both experimental and epidemiological studies suggest that exposure to the endocrine disruptor bisphenol A (BPA) has a role in metabolic disorders. The aim of the present study was to assess whether urinary BPA concentrations were associated with dyslipidaemia in children (≤17 years old) and adults (≥18 years old) by performing a meta-analysis of data from six cycles (2003–2014) in the National Health and Nutrition Examination Survey (NHANES).MethodsWe conducted a meta-analysis of data from 4604 children and 10 989 adult participants who were part of a substudy of urinary BPA measurements from six NHANES cycles from 2003 to 2014. Linear regression models conducted in each cycle were used to perform a meta-analysis to investigate associations between urinary BPA and serum levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG) and apolipoprotein B (ApoB).ResultsThe meta-analysis did not disclose any significant associations between urinary BPA concentrations and LDL-C, HDL-C, TC, TG and ApoB in children. In adults, the meta-analysis revealed negative regression coefficients for all five lipid variables. However, no associations were significant following Bonferroni correction for multiple tests.ConclusionsIn the present meta-analysis of cross-sectional data from NHANES, no associations were found between urinary BPA and the five different lipid variables when investigated in both children and adults. However, considering the cross-sectional nature of the present study, results should be clarified in carefully designed longitudinal cohort studies with repeated BPA measurements.

Mean platelet volume is significantly associated with serum levels of thyroid-stimulating hormone in a cohort of older euthyroid subjects

2015 ◽  
Vol 40 (4) ◽  
pp. 227-230 ◽  
Author(s):  
Giuseppe Lippi ◽  
Elisa Danese ◽  
Martina Montagnana ◽  
Antonio Nouvenne ◽  
Tiziana Meschi ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Platelet Volume ◽  
Stimulating Hormone
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