Effect of Indomethacin on Desoxycorticosterone Acetate-Sodium Chloride-lnduced Renal Lesions in the Pregnant Rat and Her Offspring

1980 ◽  
Vol 1 (4) ◽  
pp. 229-237 ◽  
Author(s):  
Bruce R. Parks ◽  
Ben H. Douglas ◽  
Macon M. Weaver ◽  
Jane E. Gillspie ◽  
William D. Gavenport ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Pregnant Rat ◽  
Renal Lesions ◽  
Desoxycorticosterone Acetate

scholarly journals STUDIES ON RENAL JUXTAGLOMERULAR CELLS

1953 ◽  
Vol 97 (3) ◽  
pp. 415-428 ◽  
Author(s):  
Phyllis Merritt Hartroft ◽  
W. Stanley Hartroft
Keyword(s):  
Sodium Chloride ◽  
Hormonal Regulation ◽  
Salt Intake ◽  
Juxtaglomerular Cells ◽  
Cytological Evidence ◽  
Secretory Cycle ◽  
Cent Sodium ◽  
Cytological Changes ◽  
Desoxycorticosterone Acetate ◽  
Sodium Metabolism

Accumulation of granules in the juxtaglomerular cells occurred in rats which were maintained for 5 to 6 weeks on a diet low in sodium, chloride. Cytological evidence suggests that this was probably a storage phase of secretion following a decrease in the rate of liberation of the granules. Administration of DCA (desoxycorticosterone acetate) to salt-deficient rats did not alter this appearance of the juxtaglomerular cells. Two per cent sodium chloride taken in the drinking water consumed for 4 weeks by similar animals caused degranulation of the juxtaglomerular cells. This effect was enhanced by DCA. DCA administered to animals on a normal salt intake produced a lesser degree of degranulation. Cytological changes in degranulated cells suggested that these represent a stage of hyperactivity in the secretory cycle produced by an increase in the rate of liberation of granules. A hypothesis is suggested that the juxtaglomerular cells are involved in the hormonal regulation of sodium metabolism and/or blood pressure.

scholarly journals Renal lesions in baby chicks due to sodium chloride poisoning

1983 ◽  
Vol 12 (2) ◽  
pp. 277-285 ◽  
Author(s):  
S.M. Sokkar ◽  
B.M. Hussein ◽  
M.A. Mohammed
Keyword(s):  
Sodium Chloride ◽  
Renal Lesions ◽  
Chloride Poisoning
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