scholarly journals Metastasis of Colon Cancer to the Breast

2017 ◽  
Vol 10 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Swei H. Tsung
Keyword(s):  
Colon Cancer ◽  
Metastatic Disease ◽  
Rare Event ◽  
Clinical History ◽  
Primary Cancer ◽  
Breast Metastases ◽  
Proper Diagnosis ◽  
High Level

Breast metastases from extramammary neoplasms are extremely rare, and even more so is metastasis of colon cancer to the breast. Despite its rarity, metastatic disease to the breast is an important diagnostic issue because its treatment differs greatly from that of primary cancer. Proper diagnosis of this rare event requires an accurate clinical history, proper immunohistochemical workup, and a high level of suspicion.

Radiological manifestations of metastasis to the ovary

2012 ◽  
Vol 65 (7) ◽  
pp. 585-590 ◽  
Author(s):  
Fredric Willmott ◽  
Kader Abdel Allouni ◽  
Andrea Rockall
Keyword(s):  
Ovarian Cancer ◽  
Metastatic Disease ◽  
Early Stage ◽  
Primary Tumour ◽  
High Rate ◽  
Primary Cancer ◽  
Primary Ovarian Cancer ◽  
Radiological Features ◽  
History Of ◽  
Ovarian Lesion

MRI is an effective tool for detection of ovarian neoplastic lesions. However, there are no highly specific radiological features that differentiate primary from metastatic ovarian masses. Histological diagnosis preoperatively is not always possible as there is a risk of disseminating an otherwise early stage primary ovarian cancer. The preoperative diagnosis of an ovarian lesion is therefore heavily dependent on the radiological features. The radiologist must rely on a combination of knowing the natural history of any known primary cancer, together with the radiological features such as bilaterality, mucinous appearance, pseudomyxoma as well as the clinical progress of the primary tumour in order to evaluate and predict the likelihood of metastatic disease. Even if a non-ovarian primary cancer is known, an ovarian mass cannot always be assumed to be a secondary lesion. Some tumours, such as BRAC-positive breast cancer, are known to have a high rate of concomitant primary ovarian cancer. Conversely, other tumours, such as gastric and appendiceal cancer, are known to have a high rate of ovarian metastatic disease. However, histology remains the only true way to determine an ovarian metastasis from a primary lesion.

scholarly journals Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Andreas Sperlich ◽  
Alexander Balmert ◽  
Dietrich Doll ◽  
Sabine Bauer ◽  
Fabian Franke ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Metastatic Disease ◽  
Disease Recurrence ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

scholarly journals Injection ranitidine induced death

2020 ◽  
Vol 9 (10) ◽  
pp. 1607
Author(s):  
S. Anandhi ◽  
R. Mani
Keyword(s):  
Receptor Antagonist ◽  
World Wide ◽  
Rare Event ◽  
Clinical History ◽  
Histological Data ◽  
History Of ◽  
Prior Administration

Ranitidine is a histamine-2-receptor antagonist. It was a commonly used drug. It holds excellent safety record. Anaphylactic reactions to ranitidine is uncommonly encountered. Death due to ranitidine is extremely a rare event and very few cases are reported world-wide. Clinical history, Lab investigations and histological data of a 43-Years old woman with negative history of allergic events, who died suddenly after the intra-venous administration of 50mg of intravenous ranitidine which was prescribed as a routine pre medication prior hysterectomy is presented below. Though the incidence of anaphylactic reactions is less with ranitidine, precautions to be taken prior administration of the drug and when such an event is encountered it should be promptly managed.

scholarly journals Tumor sidedness influences prognostic impact of lymph node metastasis in colon cancer patients undergoing curative surgery

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hsin-Wu Lai ◽  
James Cheng-Chung Wei ◽  
Hung-Chang Hung ◽  
Chun-Che Lin
Keyword(s):  
Colon Cancer ◽  
Proportional Hazards ◽  
Stage I ◽  
Prognostic Impact ◽  
Curative Surgery ◽  
Node Metastasis ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
High Level ◽  
Worse Prognosis

AbstractThis study aimed to evaluate prognostic impacts of the number of lymph nodes (LNs) examined and LN ratio on cancer-specific mortality after surgery in patients with right-sided colon cancer (RCC) or left-sided colon cancer (LCC) using the Surveillance, Epidemiology, and End Results database. Number of LNs examined and LN ratio were treated as categorical and/or continuous. Competing risks proportional hazards regressions adjusted by propensity score were performed. All included patients had stage I, II, or III disease, and 45.1% of them had RCC. RCC and LCC patients with high level of LNs examined had better prognosis after segmental resection or hemicolectomy. RCC and LCC patients with higher LN ratio had worse prognosis regardless of surgery. Survival benefit of having high level of LNs examined was observed in RCC patients with stage I, II, or III disease, but only in LCC patients with stage II disease. Both higher LN ratio and high level of LN were negative prognostic factors for cancer-specific mortality in stage III patients regardless of tumor sidedness. In conclusion, RCC patients in various conditions had worse or comparable prognosis compared to their LCC counterparts, which reflected the severity of LN metastasis.

Right Versus Left Colon Cancer: Resectable and Metastatic Disease

2018 ◽  
Vol 19 (6) ◽  
Author(s):  
Michele Ghidini ◽  
Fausto Petrelli ◽  
Gianluca Tomasello
Keyword(s):  
Colon Cancer ◽  
Metastatic Disease ◽  
Left Colon ◽  
Left Colon Cancer

Directed Injection of Vertebroplastic Cement at the Site of a Lytic Metastatic Lesion Restores Strength With Minimum Injection Volume

2012 ◽  
Author(s):  
Ata M. Kiapour ◽  
Eeric Truumees ◽  
Vijay K. Goel ◽  
Constantine K. Demetropoulos
Keyword(s):  
Metastatic Disease ◽  
Thoracolumbar Spine ◽  
Pathologic Fracture ◽  
Osteoporotic Fractures ◽  
Clinical History ◽  
Metastatic Lesion ◽  
Cement Augmentation ◽  
Adjacent Segment ◽  
Tumor Lysis ◽  
Vertebral Stabilization

Metastatic disease in the thoracolumbar spine represents a large and growing problem. These metastases can lead to pain, pathologic fracture, and neurologic compromise. Over the last two decades, the utilization of polymethylmethacrylate (PMMA) for percutaneous vertebral stabilization has increased. Most of the biomechanical and outcomes data addresses the use of vertebroplasty and kyphoplasty procedures for osteoporotic fractures [1,2]. Use of these procedures for metastatic disease enjoys a long clinical history, but the outcomes and complications are notably higher than in osteoporosis [3,4]. Newer formulations of PMMA used in advanced systems such as the Perimeter System (DePuy, Raynham, MA) may allow carefully controlled, anatomically directed PMMA application with far greater control. However, The relative benefits of these newer, proprietary systems have not been demonstrated. Proposed benefits of direct void reconstruction, as opposed to anterior vertebral body fill include: tumor lysis, decreased risk of later tumor growth with canal compromise, the ability to use less total PMMA, decreased impact on adjacent segment mechanics, and therefore, a decreased adjacent segment fracture risk. This study was conducted to examine and compare the biomechanical effectiveness of the cement augmentation (vertebroplasty) and directed PMMA injection using the Perimeter system.

Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcome.

1998 ◽  
Vol 16 (7) ◽  
pp. 2478-2485 ◽  
Author(s):  
W G Scheurlen ◽  
G C Schwabe ◽  
S Joos ◽  
J Mollenhauer ◽  
N Sörensen ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Metastatic Disease ◽  
Large Scale ◽  
Clinical Stage ◽  
Fatal Outcome ◽  
Prognostic Significance ◽  
Primary Tumors ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
High Level

PURPOSE The diagnostic and prognostic significance of well-defined molecular markers was investigated in childhood primitive neuroectodermal tumors (PNET). MATERIALS AND METHODS Using microsatellite analysis, Southern blot analysis, and fluorescence in situ hybridization (FISH), 30 primary tumors and six CSF metastasis specimens were analyzed for loss of heterozygosity (LOH) of chromosomes 1q31, 6q, 9q22, 10q, 11, 16q22, and 17p13.1 and/or high-level amplification of the c-myc gene. Experimental data were compared with clinical stage and outcome. RESULTS LOH of chromosome 17p13.1 was found most frequently (14 of 30 tumors, six of six CSF metastasis specimens); LOH of chromosomes 10q, 16q22, 11, 6, 9q22, and 1q31 was observed in 20.6%, 20%, 14.3%, 12%, 10%, and 0%, respectively. Eight of 32 tumors and CSF specimens showed amplification of c-myc. All tumors with amplification of c-myc were resistant to therapy and had a fatal outcome (mean survival time, 9.3 months). Tumors that displayed LOH of chromosome 17p were associated with metastatic disease. The prognosis of these tumors was worse only when associated with amplification of c-myc. Three of three patients with LOH of 9q22 relapsed. CONCLUSION In our study, amplification of c-myc was a poor-prognosis marker in PNET. LOH of chromosome 17p was associated with metastatic disease. Molecular analysis of primary tumors using these markers may be useful for stratification of children with PNET in future prospective studies. The other aberrations investigated were not of significant prognostic value, but may provide an entry point for future large-scale molecular studies.

scholarly journals Olanzapine-associated hypothermia: a case report of a rare event

2018 ◽  
Vol 12 (1) ◽  
pp. 67 ◽  
Author(s):  
Manuel Monti ◽  
Valeria Mommi ◽  
Maria Beatrice Forte ◽  
Francesco Paciullo ◽  
Francesca Francavilla ◽  
...  
Keyword(s):  
Body Temperature ◽  
Rare Event ◽  
Clinical History ◽  
Clinical Findings ◽  
The Body ◽  
Warning Sign ◽  
Cord Injury ◽  
Level Of Consciousness ◽  
Olanzapine Therapy ◽  
Chest X Ray

Hypothermia, a potentially fatal condition, is defined as a drop of the body temperature below 35°C. The most common cause of severe hypothermia is the environmental exposure to low-temperatures. Other causes include septicemia, diabetic ketoacidosis, trauma, acute spinal cord injury, prolonged cardiac arrest and hypothyroidism. The hypothermia is an infrequent, but previously documented, adverse effect of antipsychotic medications. A 83-year-old Italian woman was transported to the Emergency Room with a reduced level of consciousness, Glasgow coma scale 7. She was bradycardic (heart rate 42 bpm), 80/150 mmHg blood pressure and respiratory rate 26/min. Her physical examination was significant for an anal temperature of 31°C. Blood exam and chest X-ray were unremarkable. In her clinical history, she was suffering from generalized anxiety disorder for the last 2 years and was prescribed olanzapine 7.5 mg daily. In recent days, the patient experienced a cognitive impairment with heat intolerance and had been reduced the dose of olanzapine 5 mg daily. On the basis of the clinical findings, the patient’s body temperature and blood exam, the diagnosis of olanzapine-associated hypothermia was made. The patient was gradually rewarmed with blankets and warm saline infusion and the olanzapine therapy was discontinued. She gradually regained consciousness after 18 h and, after 1 day, the patient’s body temperature increased up to 37.8°C with an improvement of the neurological conditions. We reported about the case of a patient treated with stable doses of olanzapine for a long period of time that developed hypothermia, a potentially fatal complication. This case shows that it is important to consider every change in the patient behavior, e.g., the poor resistance to heat present in our patient, that should exhibit warning sign of hypothermia.

Multiple Liver Lesions and Family History of Colon Cancer: Metastatic Disease? Think Again

2013 ◽  
Vol 108 ◽  
pp. S159
Author(s):  
Srikala Meda ◽  
Krishna Ayyagari ◽  
Sindhu Kaitha ◽  
Vijay Babu Adimoolam
Keyword(s):  
Colon Cancer ◽  
Family History ◽  
Metastatic Disease ◽  
Liver Lesions ◽  
History Of
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