scholarly journals Molecular Characteristics of Pancreatic Ductal Adenocarcinomas with High-Grade Pancreatic Intraepithelial Neoplasia (PanIN) Are Different from Those without High-Grade PanIN

Pathobiology ◽  
2017 ◽  
Vol 84 (4) ◽  
pp. 192-201 ◽  
Author(s):  
Tetsuyuki Miyazaki ◽  
Yoshihiro Ohishi ◽  
Yoshihiro Miyasaka ◽  
Yasunori Oda ◽  
Shinichi Aishima ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Molecular Characteristics ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia

scholarly journals Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

2017 ◽  
Vol 242 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Waki Hosoda ◽  
Peter Chianchiano ◽  
James F Griffin ◽  
Meredith E Pittman ◽  
Lodewijk AA Brosens ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Genetic Analyses

scholarly journals A hypoechoic, tumor-like lesion in the pancreatic head and neck on endoscopic ultrasonography may be due to a high-grade pancreatic intraepithelial neoplasia/carcinoma in situ

2021 ◽  
pp. 50
Author(s):  
◽  
◽  
◽  
Keyword(s):  
Head And Neck ◽  
Pancreatic Duct ◽  
Carcinoma In Situ ◽  
Pancreatic Head ◽  
Intraepithelial Neoplasia ◽  
Ductal Adenocarcinoma ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Cytologic Examination

High-grade pancreatic intraepithelial neoplasia (HG PanIN)/carcinoma in situ (CIS) in the pancreatic body and tail can induce parenchymal atrophy through chronic inflammatory changes presenting as a Hypoechoic area on EUS (Hypocho) or focal pancreatic parenchymal atrophy (FPPA) on computed tomography (CT) and magnetic resonance imaging (MRI). We herein discussed two patients with a hypoechoic area in the pancreatic head and neck on EUS resembling pancreatic ductal adenocarcinoma (PDAC). The lesions consisted of dense fibrosis and fat infiltration with pancreatic parenchymal atrophy around the HG PanIN/CIS in the main pancreatic duct (MPD), which penetrated the lesion and showed mild stenosis and upstream dilation. CT and MRI were unable to visualize the lesions. A specimen was obtained from one lesion by fine-needle aspiration under EUS (EUS-FNA) guidance for histopathological and cytological analysis, but the tests returned negative for adenocarcinoma. However, serial pancreatic-juice aspiration cytologic examination (SPACE) revealed adenocarcinoma in both lesions, prompting surgical resection. Histopathological examination revealed non-invasive HG PanIN/CIS in the MPD surrounded by dense fibrosis and fat deposition in the area of parenchymal atrophy. The CIS was restricted to the area of parenchymal atrophy.These two cases are noteworthy in illustrating a hypoechoic area appearing on EUS as a tumor-like lesion resembling PDAC. EUS-FNA has recently been used histopathologically to diagnose a pancreatic lesion. However, in the present and similar cases, EUS-FNA can only reveal secondary changes due to CIS unless the pancreatic duct covered by the CIS is accidentally punctured. We should bear in mind that CIS can appear as a hypoechoic area resembling PDAC on EUS, and that SPACE is the best method for diagnosing CIS in such cases.

scholarly journals Microinvasion of High-Grade Pancreatic Intraepithelial Neoplasia

2013 ◽  
Vol 7 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Natsuko Kawada ◽  
Hiroyuki Uehara ◽  
Ryoji Takada ◽  
Takuo Yamai ◽  
Nobuyasu Fukutake ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Pancreatic Intraepithelial Neoplasia

High-Grade Pancreatic Intraepithelial Neoplasia in a Patient With Familial Adenomatous Polyposis

2005 ◽  
Vol 129 (11) ◽  
pp. 1398-1400 ◽  
Author(s):  
Chakshu Gupta ◽  
Paul F. Mazzara
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Precancerous Lesions ◽  
English Literature ◽  
Intraepithelial Neoplasia ◽  
Colorectal Adenomas ◽  
Pancreatic Ducts ◽  
High Grade ◽  
Adenomatous Polyposis ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Increased Risk

Abstract Familial adenomatous polyposis (FAP) is caused by mutation of the adenomatous polyposis coli (APC) gene and is characterized by multiple colorectal adenomas and tumors of other organs and sites. A 58-year-old woman with FAP syndrome and previous total colectomy presented for routine follow-up examination. Abdominal ultrasound and subsequent endoscopic evaluation revealed ampullary and duodenal polyps, as well as inhomogeneity of the pancreatic head. A pancreaticoduodenectomy confirmed multiple duodenal adenomas. In addition, high-grade pancreatic intraepithelial neoplasia (PanIN-3) was found in the smaller pancreatic ducts. Pancreatic precancerous lesions have only rarely been described in FAP, including 2 pancreatic duct adenomas and 2 intraductal papillary mucinous neoplasms. A review of the world English literature revealed no reports of PanIN-3 in association with FAP. Further studies are required to determine if patients with FAP are at increased risk for pancreatic premalignant lesions.

scholarly journals Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

2018 ◽  
Vol 188 (7) ◽  
pp. 1723-1733 ◽  
Author(s):  
Tatsuo Hata ◽  
Masaya Suenaga ◽  
Luigi Marchionni ◽  
Anne Macgregor-Das ◽  
Jun Yu ◽  
...  
Keyword(s):  
Copy Number ◽  
Intraepithelial Neoplasia ◽  
High Grade ◽  
Copy Number Alterations ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Genome Wide ◽  
Somatic Copy Number Alterations
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