scholarly journals Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations

Nephron Extra ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Sanjeet Roy ◽  
Anila Korula ◽  
Gopal Basu ◽  
Shibu Jacob ◽  
Santosh Varughese ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Phospholipase A2 Receptor ◽  
Secondary Membranous Nephropathy ◽  
Clinicopathological Correlations

scholarly journals Retrospective Study of Phospholipase A2 Receptor and IgG Subclasses in Glomerular Deposits in Chinese Patients with Membranous Nephropathy

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156263 ◽  
Author(s):  
Hong-rui Dong ◽  
Yan-yan Wang ◽  
Xiao-hong Cheng ◽  
Guo-qing Wang ◽  
Li-jun Sun ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Igg Subclasses ◽  
Chinese Patients ◽  
Phospholipase A2 Receptor ◽  
Glomerular Deposits

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy

2015 ◽  
Vol 41 (4-5) ◽  
pp. 345-353 ◽  
Author(s):  
Qionghong Xie ◽  
Yan Li ◽  
Jun Xue ◽  
Zuquan Xiong ◽  
Liang Wang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Class V ◽  
Primary Glomerulonephritis ◽  
Capillary Loop ◽  
Phospholipase A2 Receptor ◽  
Secondary Membranous Nephropathy ◽  
B Virus

Objective: This study examined the expression of renal phospholipase A2 receptor (PLA2R) in idiopathic and secondary membranous nephropathy (MN). Methods: Patients with biopsy-proven MN and non-MN were enrolled. Renal PLA2R was examined using an anti-PLA2R antibody (anti-PLA2R-Ab), and circulating PLA2R-Ab was detected by indirect immunofluorescence. Results: Renal PLA2R was detected along the capillary loop in 84% patients with idiopathic MN but not in those with any other primary glomerulonephritis. Only 1 of 38 patients with class V lupus nephritis showed renal PLA2R positive. In hepatitis B virus-associated MN (HBV-MN), 64% showed renal PLA2R positive, and PLA2R overlapped with HBsAg along the capillary loop. In addition, renal PLA2R positivity was closely associated with serum PLA2R-Ab. Renal PLA2R positive was present in all the patients with serum PLA2R-Ab positive and in 53% of patients with serum PLA2R-Ab negative. However, in patients with renal PLA2R negative, serum PLA2R-Ab was all negative. Conclusion: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN.

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