scholarly journals Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 43 (1-3) ◽  
pp. 101-122 ◽  
Author(s):  
Graziella D'Arrigo ◽  
Rossella Baggetta ◽  
Giovanni Tripepi ◽  
Francesco Galli ◽  
Davide Bolignano
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Vitamin E ◽  
Meta Analysis ◽  
Resistance Index ◽  
Thiobarbituric Acid ◽  
Chronic Hemodialysis ◽  
Dialysis Adequacy ◽  
Erythropoietin Resistance Index ◽  
Erythropoietin Resistance

Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

Erythropoietin Resistance Index and the All-Cause Mortality of Chronic Hemodialysis Patients

2014 ◽  
Vol 37 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Masayuki Okazaki ◽  
Mizuki Komatsu ◽  
Hiroshi Kawaguchi ◽  
Ken Tsuchiya ◽  
Kosaku Nitta
Keyword(s):  
Resistance Index ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
All Cause Mortality ◽  
Erythropoietin Resistance Index ◽  
Erythropoietin Resistance

Effects of vitamin E-coated dialyzer on oxidative stress and inflammation status in hemodialysis patients: a systematic review and meta-analysis

Renal Failure ◽  
2014 ◽  
Vol 36 (5) ◽  
pp. 722-731 ◽  
Author(s):  
Shi-Kun Yang ◽  
Li Xiao ◽  
Bo Xu ◽  
Xiao-Xuan Xu ◽  
Fu-You Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Vitamin E ◽  
Meta Analysis ◽  
Hemodialysis Patients

scholarly journals Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 22 (21) ◽  
pp. 11923
Author(s):  
Thi Thuy Uyen Nguyen ◽  
Ji-hyun Yeom ◽  
Won Kim
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Vitamin E ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Oxidative Stress Biomarkers ◽  
Randomized Controlled ◽  
Stress Biomarkers ◽  
And Oxidative Stress ◽  
Vitamin E Supplementation

Inflammation and oxidative stress are closely related to cardiovascular complications and atherosclerosis, and have the potential to lead to an increase in death in patients receiving hemodialysis. Vitamin E has antioxidant and anti-inflammatory properties. We conducted a systematic review and meta-analysis to assess the effects of vitamin E supplementation on endothelial dysfunction, inflammation, and oxidative stress biomarkers in adult patients receiving hemodialysis. We searched the MEDLINE, EMBASE, Web of Science, and Cochrane Library databases and identified randomized controlled trials of adult patients receiving hemodialysis until 30 August 2021. A total of 11 trials with 491 randomized patients were included. The pooled data indicated that vitamin E supplementation significantly decreased intercellular adhesion molecule-1 [standardized mean difference (SMD): −1.35; 95% confidence interval (CI): −2.57, −0.13; p = 0.03, I2 = 89%], vascular cell adhesion molecule-1 (SMD: −1.08; 95% CI: −2.05, −0.11; p = 0.03, I2 = 81%), C-reactive protein (SMD: −0.41; 95% CI: −0.75, −0.07; p = 0.02, I2 = 64%), and malondialdehyde (SMD: −0.76; 95% CI: −1.26, −0.25; p = 0.003, I2 = 77%) levels, but not interleukin-6 levels compared to those in the control group. Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.

scholarly journals FP662INFLUENCE OF CYTOKINE GENE POLYMORPHISM ON ERYTHROPOIETIN RESISTANCE INDEX IN CHRONIC HEMODIALYSIS PATIENTS

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii295-iii295
Author(s):  
Nada Dimkovic ◽  
Petar S Djuric ◽  
Jelena Tosic ◽  
Aleksandar Jankovic ◽  
Marko Barovic ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Resistance Index ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphism ◽  
Erythropoietin Resistance Index ◽  
Erythropoietin Resistance

Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on oxidative stress parameters: A systematic review and meta-analysis

2020 ◽  
Vol 39 (4) ◽  
pp. 1019-1025 ◽  
Author(s):  
Mahdi Sepidarkish ◽  
Maryam Akbari-Fakhrabadi ◽  
Elnaz Daneshzad ◽  
Mahsa Yavari ◽  
Mahroo Rezaeinejad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Fatty Acid ◽  
Vitamin E ◽  
Meta Analysis ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Peter Bergin ◽  
Aoife Leggett ◽  
Chris R. Cardwell ◽  
Jayne V. Woodside ◽  
Ammarin Thakkinstian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Vitamin E ◽  
Meta Analysis ◽  
Antioxidant Properties ◽  
Premature Mortality ◽  
Study Data ◽  
Before And After ◽  
Randomised Control Trials ◽  
Methodological Approaches

Abstract Background Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS, are reduced by the antioxidant properties of vitamin E (VE) but outcomes from randomised control trials of VE supplementation on MDA in HD patients have been inconsistent. Methods We undertook a systematic review and meta-analysis of adult HD patients from VE supplementation studies with measures of MDA. The following search criteria of MEDLINE and EMBASE were considered from inception to January 2020: ‘dialysis’ AND ‘Vitamin E OR tocopherol’ AND ‘malondialdehyde OR MDA’. Two reviewers independently extracted study data and assessed risk of bias. Mean MDA levels and standard deviation were determined before and after VE supplementation. Standardised mean difference (SMD) and standard error were calculated as the within person difference and units of measure were not consistently recorded across all studies. The SMD were pooled using random effects meta-analysis. Results The SMD of MDA levels from 18 comparisons was significantly lower in HD patients following VE supplementation (− 1.55; confidence interval: − 2.17 to − 0.94, P < 0.00001). There were significant levels of heterogeneity between studies (I2 value = 91%; P < 0.00001) with evidence of potential publication bias toward smaller studies. Conclusions Our findings support the use of VE to reduce the effects of OS in HD patients although high levels of heterogeneity and variation in the methodological approaches used by some studies highlight the need for further investigation.

Relationships among the Dosage of Erythropoiesis-Stimulating Agents, Erythropoietin Resistance Index, and Mortality in Maintenance Hemodialysis Patients

2021 ◽  
pp. 1-11
Author(s):  
Sai Pan ◽  
De-Long Zhao ◽  
Ping Li ◽  
Xue-Feng Sun ◽  
Jian-Hui Zhou ◽  
...  
Keyword(s):  
Propensity Score ◽  
Propensity Score Matching ◽  
Cox Regression ◽  
Resistance Index ◽  
Cox Proportional Hazards Model ◽  
Maintenance Hemodialysis ◽  
Erythropoiesis Stimulating Agents ◽  
All Cause Mortality ◽  
Erythropoietin Resistance Index ◽  
Erythropoietin Resistance

<b><i>Background:</i></b> Erythropoiesis-stimulating agents (ESAs) constitute an important treatment option for anemia in hemodialysis (HD) patients. We investigated the relationships among the dosage of ESA, erythropoietin resistance index (ERI) scores, and mortality in Chinese MHD patients. <b><i>Methods:</i></b> This multicenter observational retrospective study included MHD patients from 16 blood purification centers (<i>n</i> = 824) who underwent HD in 2011–2015 and were followed up until December 31, 2016. We collected demographic variables, HD parameters, laboratory values, and ESA dosages. Patients were grouped into quartiles according to ESA dosage to study the effect of ESA dosage on all-cause mortality. The ERI was calculated as follows: ESA (IU/week)/weight (kg)/hemoglobin levels (g/dL). We also compared outcomes among the patients stratified into quartiles according to ERI scores. We used the Cox proportional hazards model to measure the relationships between the ESA dosage, ERI scores, and all-cause mortality. Using propensity score matching, we compared mortality between groups according to ERI scores, classified as either &#x3e; or ≤12.80. <b><i>Results:</i></b> In total, 824 patients were enrolled in the study; 200 (24.3%) all-cause deaths occurred within the observation period. Kaplan-Meier analyses showed that patients administered high dosages of ESAs had significantly worse survival than those administered low dosages of ESAs. A multivariate Cox regression identified that high dosages of ESAs could significantly predict mortality (ESA dosage &#x3e;10,000.0 IU/week, HR = 1.59, 95% confidence intervals (CIs) (1.04, 2.42), and <i>p</i> = 0.031). Our analysis also indicated a significant increase in the risk of mortality in patients with high ERI scores. Propensity score matching-analyses confirmed that ERI &#x3e; 12.80 could significantly predict mortality (HR = 1.56, 95% CI [1.11, 2.18], and <i>p</i> = 0.010). <b><i>Conclusions:</i></b> Our data suggested that ESA dosages &#x3e;10,000.0 IU/week in the first 3 months constitute an independent predictor of all-cause mortality among Chinese MHD patients. A higher degree of resistance to ESA was related to a higher risk of all-cause mortality.

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