scholarly journals Early Motor Fluctuations in a Patient with Striatonigral Degeneration

2016 ◽  
Vol 8 (3) ◽  
pp. 243-250
Author(s):  
Fumihito Yoshii ◽  
Yusuke Moriya ◽  
Tomohide Ohnuki ◽  
Wakoh Takahashi ◽  
Masafuchi Ryo
Keyword(s):  
Marked Decrease ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Striatonigral Degeneration ◽  
Recovery Sequence ◽  
Positron Emission ◽  
Fluid Attenuated Inversion Recovery ◽  
Wearing Off ◽  
Magnetic Resonance Imaging Mri ◽  
The Right

We report a 44-year-old female with striatonigral degeneration (SND) who showed wearing-off oscillations after 4 months of levodopa treatment. The patient presented with asymmetric left-side dominant rigidity, and levodopa was effective at first. However, she began to show wearing-off oscillations of motor symptoms, which gradually worsened thereafter. Fluid-attenuated inversion recovery sequence magnetic resonance imaging (MRI) showed linear lateral putamen hyperintensities, and positron emission tomography (PET) studies using 18F-fluorodopa (FD) and 11C-N-methylspiperon (NMSP) showed a marked decrease of radioactivity in the right putamen, especially in the posterior putamen. The results of MRI and 2 PET studies with FD and NMSP were well consistent with the diagnosis of SND.

scholarly journals Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

2019 ◽  
Vol 12 (3) ◽  
pp. 137 ◽  
Author(s):  
Julia Greiser ◽  
Wolfgang Weigand ◽  
Martin Freesmeyer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Metal Complexes ◽  
Imaging Technique ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri ◽  
Uptake Mechanisms

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.

Sign in / Sign up

Export Citation Format

Share Document