scholarly journals Urine Epidermal Growth Factor, Monocyte Chemoattractant Protein-1 or Their Ratio as Biomarkers for Interstitial Fibrosis and Tubular Atrophy in Primary Glomerulonephritis

2016 ◽  
Vol 41 (6) ◽  
pp. 997-1007 ◽  
Author(s):  
Supanat Worawichawong ◽  
Suchin Worawichawong ◽  
Piyanuch Radinahamed ◽  
Dittapol Muntham ◽  
Nuankanya Sathirapongsasuti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Interstitial Fibrosis ◽  
Tubular Atrophy ◽  
Primary Glomerulonephritis ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Epidermal Growth

scholarly journals Biological Determinants of and Reference Values for Plasma Interleukin-8, Monocyte Chemoattractant Protein-1, Epidermal Growth Factor, and Vascular Endothelial Growth Factor: Results from the STANISLAS Cohort

2006 ◽  
Vol 52 (3) ◽  
pp. 504-510 ◽  
Author(s):  
Hind Berrahmoune ◽  
John V Lamont ◽  
Bernard Herbeth ◽  
Peter S FitzGerald ◽  
Sophie Visvikis-Siest
Keyword(s):  
Platelet Count ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Monocyte Count ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Epidermal Growth ◽  
Age Range ◽  
Endothelial Growth Factor

Abstract Background: Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are known to be involved in various diseases related to inflammation, vascular remodeling, or growth deregulation. In addition, increases in plasma concentrations of these cytokines appear to provide useful diagnostic and prognostic information. We therefore investigated which factors most strongly influence the biological variations of plasma IL-8, MCP-1, EGF, and VEGF concentrations. Methods: We used the Evidence® biochip array analyzer to quantify plasma IL-8, MCP-1, EGF, and VEGF concentrations in a subsample of 304 children (age range, 4–17 years) and 540 adults (age range, 18–55 years) from the STANISLAS family study. We also calculated reference intervals for the 4 cytokines. Results: We found the following associations with plasma marker concentrations: Age, neutrophil count, and glucose concentration were positively associated with IL-8 concentrations in children and adults, as were smoking and platelet count in adults. MCP-1 concentrations were associated with age and smoking in both children and adults, monocyte count in children, and sex and hematocrit in adults. EGF concentrations were associated with platelet count in children and monocyte count and glucose in adults. VEGF concentrations were associated with age in children and adults and platelet count and alanine aminotransferase activity in adults. Conclusion: Our results for IL-8, MCP-1, EGF, and VEGF may be useful for interpretation of patients’ laboratory results and for understanding the regulation of concentrations of these cytokines in physiologic conditions.

Sign in / Sign up

Export Citation Format

Share Document