Sodium Pentosan Polysulfate Reduced Renal Ischemia-Reperfusion-Induced Oxidative Stress and Inflammatory Responses in an Experimental Animal Model

2016 ◽  
Vol 53 (3-4) ◽  
pp. 230-242 ◽  
Author(s):  
Péter Hardi ◽  
Tibor Nagy ◽  
Gábor Fazekas ◽  
Endre Arató ◽  
Gábor Menyhei ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Experimental Animal ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Experimental Animal Model ◽  
Pentosan Polysulfate ◽  
Sodium Pentosan Polysulfate

scholarly journals The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression

2013 ◽  
Vol 51 (5) ◽  
pp. 533-538 ◽  
Author(s):  
Carlos Alberto Yasin Wayhs ◽  
Caroline Tortato ◽  
Caroline Paula Mescka ◽  
Matheus Augusto Pasquali ◽  
Carlos Eduardo Schnorr ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Experimental Animal ◽  
Experimental Animal Model ◽  
Association Effect

Effect of Blackberry in Managment of Dry Eye in Experimental Animal Model

2018 ◽  
Vol 35 (1) ◽  
pp. 28-45
Author(s):  
Eman Salem ◽  
Hamdy Hassan ◽  
Ibrahim Badr ◽  
Ethar Mohamed ◽  
Bakinam Mohamed ◽  
...  
Keyword(s):  
Animal Model ◽  
Experimental Animal ◽  
Dry Eye ◽  
Experimental Animal Model

Molecular Dissection of Renal Ischemia-Reperfusion: Oxidative Stress and Cellular Events

2016 ◽  
Vol 23 (19) ◽  
pp. 1965-1980 ◽  
Author(s):  
Branislav Rovcanin ◽  
Branislava Medic ◽  
Gordana Kocic ◽  
Tatjana Cebovic ◽  
Marko Ristic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Molecular Dissection ◽  
Cellular Events

scholarly journals Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Da Tang ◽  
Guang Fu ◽  
Wenbo Li ◽  
Ping Sun ◽  
Patricia A. Loughran ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Serum Aminotransferase ◽  
Primary Mouse ◽  
Maresin 1

Abstract Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown to suppress I/R injury. However, the mechanisms that account for the protective effects of MaR1 in I/R injury remain unknown. Methods WT (C57BL/6J) mice were subjected to partial hepatic warm ischemia for 60mins followed by reperfusion. Mice were treated with MaR1 (5-20 ng/mouse), Boc2 (Lipoxin A4 receptor antagonist), LY294002 (Akt inhibitor) or corresponding controls just prior to liver I/R or at the beginning of reperfusion. Blood and liver samples were collected at 6 h post-reperfusion. Serum aminotransferase, histopathologic changes, inflammatory cytokines, and oxidative stress were analyzed to evaluate liver injury. Signaling pathways were also investigated in vitro using primary mouse hepatocyte (HC) cultures to identify underlying mechanisms for MaR1 in liver I/R injury. Results MaR1 treatment significantly reduced ALT and AST levels, diminished necrotic areas, suppressed inflammatory responses, attenuated oxidative stress and decreased hepatocyte apoptosis in liver after I/R. Akt signaling was significantly increased in the MaR1-treated liver I/R group compared with controls. The protective effect of MaR1 was abrogated by pretreatment with Boc2, which together with MaR1-induced Akt activation. MaR1-mediated liver protection was reversed by inhibition of Akt. Conclusions MaR1 protects the liver against hepatic I/R injury via an ALXR/Akt signaling pathway. MaR1 may represent a novel therapeutic agent to mitigate the detrimental effects of I/R-induced liver injury.

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