Immunohistochemical Staining of Histological Fragments Derived from Salivary Gland Tumour Fine-Needle Biopsy Aspirates

2016 ◽  
Vol 61 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Marie Lundberg ◽  
Berent Munsterhjelm ◽  
Antti Mäkitie ◽  
Ilmo Leivo
Keyword(s):  
Salivary Gland ◽  
Fine Needle Biopsy ◽  
Added Value ◽  
University Hospital ◽  
Differential Diagnostics ◽  
Fine Needle ◽  
Salivary Gland Tumours ◽  
Pathology Reports ◽  
Gland Tumour ◽  
Malignant Diagnosis

Objectives: The aim of this study was to describe a method for analysing histological fragments derived from fine- needle aspirate biopsy (FNAB) of salivary gland tumours (SGTs), and to evaluate the use of immunohistochemistry (IHC) on them. Study Design: We reviewed all 509 FNAB pathology reports taken from SGTs at Helsinki University Hospital, Finland, between 1999 and 2009. In 51% of the cases (n = 209) “histo-fragments” had been obtained and 31 had been further analysed by IHC. Of these, 25 (81%) were available for review. We evaluated the benefit of IHC by relating its added value to the preoperative cytological diagnosis and its accuracy compared with the postoperative histological diagnosis. Results: Most of the samples analysed by IHC were assigned a malignant diagnosis, with 12 different types of malignancy represented. IHC was advantageous in 76% of the cases. In the 108 studies using IHC in this series, antibodies to 36 different antigens were used. Conclusion: Analysis of histo-fragments in FNABs using IHC can be valuable in specific differential diagnostics and raises diagnostic accuracy in SGTs.

scholarly journals Diagnostic Accuracy of Fine-Needle Biopsy for Salivary Gland Neoplasms in a Community Otolaryngology Practice

OTO Open ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 2473974X2094918
Author(s):  
Jennifer L. Harb ◽  
Dara Bakar ◽  
Jagdish K. Dhingra
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Diagnostic Accuracy ◽  
Submandibular Gland ◽  
Sensitivity And Specificity ◽  
Needle Biopsy ◽  
Fine Needle Biopsy ◽  
Salivary Gland Neoplasms ◽  
Community Practice ◽  
Fine Needle

Objective To assess the diagnostic accuracy of fine-needle biopsy (FNB) of salivary gland neoplasms via ultrasound (US) or palpation guidance by an otolaryngologist in a community practice. Study Design Retrospective chart review. Setting Community otolaryngology practice. Methods Retrospective analysis was conducted for all office-based salivary gland FNBs from a community practice from 2005 through 2018. There were 433 FNBs performed among 370 patients. The likelihood of achieving a diagnostic result based on method (US vs palpation guidance) was calculated. Of this cohort, 196 cases had surgical follow-up (parotid gland, n = 168; submandibular gland, n = 28). Correlation of preoperative FNB results to final surgical pathology was performed and measures of diagnostic accuracy computed. Results US-guided FNBs were more likely to achieve a diagnostic result than FNBs obtained via palpation guidance ( P = .00002). Parotid gland FNBs demonstrated a sensitivity and specificity of 78.57% and 92.44%, respectively. Submandibular FNBs demonstrated a sensitivity and specificity of 57.14% and 93.74%. Conclusion FNBs performed under US guidance are more likely to achieve a diagnostic specimen than those performed under palpation guidance. FNBs of parotid gland tumors may be assessed with diagnostic accuracy in the community setting that is similar to that achieved at tertiary care centers. Further research is needed to ascertain whether this finding extends to FNBs of submandibular gland tumors. Offering this procedure at point of care in the community may improve compliance and reduce wait time.

scholarly journals A clinical study of the incidence of salivary gland tumors in a tertiary care teaching hospital

2019 ◽  
Vol 6 (6) ◽  
pp. 2110
Author(s):  
Sathish Babu N. ◽  
Naveen H. Mahadev ◽  
Kumar G. V.
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Critical Role ◽  
Tertiary Care ◽  
Malignant Neoplasm ◽  
Salivary Gland Tumour ◽  
Major Salivary Gland ◽  
Salivary Gland Tumours ◽  
Gland Tumour

Background: The salivary gland system of the upper aero digestive tract plays a critical role in the functions of digestion, respiration, communication, and overall homeostasis. The Salivary gland swellings can be broadly classified into inflammatory, non-inflammatory and neoplastic swellings like calculi, benign tumours such has pleomorphic adenoma, oncocytoma, Warthin's tumour, malignant tumors which include-adenocarcinoma, adenoid cystic carcinoma, undifferentiated carcinoma.Methods: The present cross-sectional study was conducted at the Department of general surgery, Sri Siddhartha Medical College over a period of 2 years from August 2016 to July 2018.  All major salivary gland neoplastic swellings confirmed by FNAC were included in this study.Results: In our study 23 patients had major salivary gland tumours out of that 19 patients had parotid and 4 had submandibular major salivary gland tumour. In our study out 23 cases of salivary tumours 19 cases were benign and 4 cases were malignant, out of 19 cases of parotid tumours, 15 (78.94%) cases were seen in superficial lobe and 4 (21.06%) were in deep lobe, out of 23 salivary gland tumours, 19 (82.6%) cases were pleomorphic adenoma 3(13.05%) cases were mucoepidermoid carcinoma and one case (4.35%) was acinic cell carcinoma.Conclusions: Parotid gland was the most common site of origin of both benign and malignant tumours, Pleomorphic adenoma was the most common benign salivary gland tumour and mucoepidermoid carcinoma was the most frequent malignant neoplasm.

Tumours of the salivary glands

2021 ◽  
pp. 885-892
Author(s):  
James Wokes ◽  
Neil McLean
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Salivary Gland ◽  
Magnetic Resonance ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Diagnostic Tools ◽  
Fine Needle ◽  
Salivary Gland Tumours ◽  
Needle Aspiration Cytology

Malignant salivary gland tumours are rare and histologically diverse. The most common tumour site is the parotid gland and most tumours are benign. The aetiological factors are numerous. Presentation of a painless swelling of a salivary gland is always considered as suspicious. Ultrasonography, computed tomography, and magnetic resonance imaging are all useful imaging modalities. Fine-needle aspiration cytology and core biopsy are valuable diagnostic tools. Surgical excision represents the mainstay of treatment for resectable tumours. Radiotherapy, chemotherapy, and immunotherapy all have roles in management.

Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis

2011 ◽  
Vol 16 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Nikos Kechagias ◽  
Aris Ntomouchtsis ◽  
Rosalia Valeri ◽  
Anna Patrikidou ◽  
Kyriaki Kitikidou ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Retrospective Analysis ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Salivary Gland Tumours ◽  
Needle Aspiration Cytology
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