The Efficacy of Antimuscarinics Alone or in Combination with Alpha-Blockers for the Treatment of Ureteral Stent-Related Symptoms: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 99 (1) ◽  
pp. 6-13 ◽  
Author(s):  
Huilei Yan ◽  
Yunhui Wang ◽  
Rong Sun ◽  
Yuanshan Cui
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Ureteral Stent ◽  
Alpha Blockers

Selective versus non-selective alpha-blockade prior to adrenalectomy for pheochromocytoma – systematic review and meta-analysis

2021 ◽  
Author(s):  
Karolina Zawadzka ◽  
Krzysztof Więckowski ◽  
Piotr Małczak ◽  
Michał Wysocki ◽  
Piotr Major ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Preoperative Treatment ◽  
Adrenergic Blockade ◽  
Alpha Blockers ◽  
Alpha Blockade ◽  
Sympathetic Paraganglioma

Objective: Alpha-adrenergic blockade is currently the first choice of preoperative treatment in patients with functional pheochromocytoma and sympathetic paraganglioma. Nevertheless, there is no consensus whether selective or non-selective alpha-blockade is superior for preventing both perioperative hemodynamic instability and complications. Design: Our study aimed to compare selective and non-selective alpha-blockade through a systematic review with meta-analysis. Methods: MEDLINE, Embase, Web of Science and Cochrane Library were searched for eligible studies. Randomized and observational studies comparing selective and non-selective alpha-blockade in pheochromocytoma and sympathetic paraganglioma surgery in adults were included. Data on perioperative hemodynamic parameters and postoperative outcomes were extracted. Results: Eleven studies with 1,344 patients were enrolled. Patients receiving selective alpha-blockade had higher maximum intraoperative systolic blood pressure (WMD 12.14 mm Hg, 95% CI 6.06-18.21, p<0.0001) compared to those treated with non-selective alpha-blockade. Additionally, in the group pretreated with selective alpha-blockers, intraoperative vasodilators were used more frequently (OR 2.46, 95% CI 1.44-4.20, p=0.001). Patients treated with selective alpha-blockers had lower minimum intraoperative systolic blood pressure (WMD -2.03 mmHg, 95% CI -4.06 to -0.01, p=0.05) and shorter length of hospital stay (WMD -0.58 days, 95% CI -1.12 to -0.04, p=0.04). Operative time, overall morbidity and mortality did not differ between the groups. Conclusions: This meta-analysis shows non-selective alpha-blockade was more effective in preventing intraoperative blood pressure fluctuations while maintaining comparable risk of both intraoperative and postoperative hypotension and overall morbidity.

scholarly journals Alpha blockers for treatment of ureteric stones: systematic review and meta-analysis

BMJ ◽  
2016 ◽  
pp. i6112 ◽  
Author(s):  
John M Hollingsworth ◽  
Benjamin K Canales ◽  
Mary A M Rogers ◽  
Shyam Sukumar ◽  
Phyllis Yan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Alpha Blockers
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