scholarly journals Colorectal Liver Metastases: A Critical Review of State of the Art

Liver Cancer ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Robert P Jones ◽  
Norihiro Kokudo ◽  
Gunnar Folprecht ◽  
Yoshihiro Mise ◽  
Michiaki Unno ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Critical Review ◽  
Colorectal Liver Metastases ◽  
State Of The Art

Colorectal Liver Metastases: State of the Art Imaging

2012 ◽  
Vol 20 (4) ◽  
pp. 1185-1193 ◽  
Author(s):  
Kathryn Jane Fowler ◽  
David C. Linehan ◽  
Christine O. Menias
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
State Of The Art

scholarly journals Critical review of the prognostic significance of pathological variables in patients undergoing resection for colorectal liver metastases

HPB ◽  
2014 ◽  
Vol 16 (9) ◽  
pp. 836-844 ◽  
Author(s):  
Dhanwant Gomez ◽  
Abed M. Zaitoun ◽  
Antonella De Rosa ◽  
Sina Hossaini ◽  
Ian J. Beckingham ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Critical Review ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance

Transarterial chemoembolization (TACE) for colorectal liver metastases—current status and critical review

2015 ◽  
Vol 400 (6) ◽  
pp. 641-659 ◽  
Author(s):  
Alexander Massmann ◽  
Thomas Rodt ◽  
Steffen Marquardt ◽  
Roland Seidel ◽  
Katrina Thomas ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Critical Review ◽  
Transarterial Chemoembolization ◽  
Colorectal Liver Metastases ◽  
Current Status

Resectability and indication for chemotherapy in patients with colorectal liver metastases as assessed by medical oncologists and surgeons.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14167-e14167
Author(s):  
Kia Homayounfar ◽  
Annalen Bleckmann ◽  
Hans-Joachim Helms ◽  
Florian Lordick ◽  
Josef Rüschoff ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Strong Influence ◽  
State Of The Art ◽  
Multidisciplinary Treatment ◽  
Tumor Board ◽  
R0 Resection ◽  
Borderline Resectable ◽  
Medical Oncologists ◽  
Significant Difference

e14167 Background: Multidisciplinary treatment in patients with colorectal liver metastases (CRLM) is standard in modern oncology. However, for interdisciplinary discussion assessing complimentary disciplines' potential and changes in personal views is crucial. We evaluated experienced medical oncologists' (MO) and surgeons' (SG) assessment of resectability and indication for chemotherapy (CTx) in patients with CRLM. Methods: Thirty patients who underwent R0-resection of CRLM between 2001 and 2011 at our department were selected. Medical history and staging data were presented to MO (n=10) and SG (n=11) in a virtual tumor board (TB1). Standardized blinded TED-voting answers (9 options) included assessment of resectability and the indication for pre- and/or postoperative CTx. The virtual tumor board was followed by training in terms of state-of-the-art lectures on potential of CTx and surgery. Assessment was then repeated in a second virtual tumor board (TB2). Results: 630 (21x30) answers were obtained per tumor board. In TB1 resectability, borderline resectability and definite unresectability were expected in 433, 161 and 36 answers, respectively. Resectability was significantly more often expected by SG (p<0.001). In TB2 57% of answers were different from TB1 (p<0.001). Assessment shifted from borderline resectable to resectable CRLM in 81 of 161 and from unresectable to (borderline) resectable CRLM in 29 of 36 answers (p<0.001). The shift was significant in MO (p=0.012) and SG (p<0.001). Preoperative CTx was significantly more often indicated by MO (p=0.041) and included in 255 answers (44%) in TB1 compared to only 157 answers (27%) in TB2 (p<0.001). With 55% of answers voting for postoperative CTx remained stable in TB1 and TB2 without a significant difference between MO and SG in either TB1 (p=0.099) or TB2 (p=0.353). Conclusions: Resectability and indication for pre- but not postoperative CTx were discrepantly assessed by MO and SG. Training had a strong influence on decision making in MO and SG resulting in a higher rate of patients deemed (borderline) resectable. Furthermore, following training MO and SG opted less often for preoperative CTx.

State of the art: colorectal liver metastases

2014 ◽  
Vol 10 (15s) ◽  
pp. 29-32
Author(s):  
Alberto Sobrero ◽  
Alessandro Pastorino
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
State Of The Art

Colorectal Liver Metastases - Does the Number of Lesions Determine the Sensibility of Resection?

Swiss Surgery ◽  
2000 ◽  
Vol 6 (1) ◽  
pp. 6-10
Author(s):  
Knoefel ◽  
Brunken ◽  
Neumann ◽  
Gundlach ◽  
Rogiers ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Rank Test ◽  
Log Rank Test ◽  
Kaplan Meier ◽  
Chirurgische Entfernung

Die komplette chirurgische Entfernung von Lebermetastasen bietet Patienten nach kolorektalem Karzinom die einzige kurative Chance. Es gibt jedoch eine, anscheinend unbegrenzte, Anzahl an Parametern, die die Prognose dieser Patienten bestimmen und damit den Sinn dieser Therapie vorhersagen können. Zu den am häufigsten diskutierten und am einfachsten zu bestimmenden Parametern gehört die Anzahl der Metastasen. Ziel dieser Studie war es daher die Wertigkeit dieses Parameters in der Literatur zu reflektieren und unsere eigenen Patientendaten zu evaluieren. Insgesamt konnte von 302 Patienten ein komplettes Follow-up erhoben werden. Die gebildeten Patientengruppen wurden mit Hilfe einer Kaplan Meier Analyse und konsekutivem log rank Test untersucht. Die Literatur wurde bis Dezember 1998 revidiert. Die Anzahl der Metastasen bestätigte sich als ein prognostisches Kriterium. Lagen drei oder mehr Metastasen vor, so war nicht nur die Wahrscheinlichkeit einer R0 Resektion deutlich geringer (17.8% versus 67.2%) sondern auch das Überleben der Patienten nach einer R0 Resektion tendenziell unwahrscheinlicher. Das 5-Jahres Überleben betrug bei > 2 Metastasen 9% bei > 2 Metastasen 36%. Das 10-Jahres Überleben beträgt bislang bei > 2 Metastasen 0% bei > 2 Metastasen 18% (p < 0.07). Die Anzahl der Metastasen spielt in der Prognose der Patienten mit kolorektalen Lebermetastasen eine Rolle. Selbst bei mehr als vier Metastasen ist jedoch gelegentlich eine R0 Resektion möglich. In diesen Fällen kann der Patient auch langfristig von einer Operation profitieren. Das wichtigere Kriterium einer onkologisch sinnvollen Resektabilität ist die Frage ob technisch und funktionell eine R0 Resektion durchführbar ist. Ist das der Fall, so sollte auch einem Patienten mit mehreren Metastasen die einzige kurative Chance einer Resektion nicht vorenthalten bleiben.

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