scholarly journals Transplantation of Autologous Bone Marrow Mononuclear Cells Regulates Inflammation in a Rabbit Model of Carotid Artery Atherosclerosis

2016 ◽  
Vol 53 (3-4) ◽  
pp. 196-205 ◽  
Author(s):  
Kefei Cui ◽  
Min Wang ◽  
Lie Yu ◽  
Xiao Ren ◽  
Hui Cui ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Carotid Artery ◽  
Mononuclear Cells ◽  
Rabbit Model ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Carotid Artery Atherosclerosis ◽  
Autologous Bone

scholarly journals Common calcaneal tendon repair with glycerin-preserved carotid artery xenografts and autologous bone marrow mononuclear cells in rabbits

2017 ◽  
Vol 53 (4) ◽  
pp. 1
Author(s):  
Robson José Gomes de Melo ◽  
Gentil Ferreira Gonçalves ◽  
Duvaldo Eurides ◽  
Patricia Romagnolli ◽  
Marshal Costa Leme ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Carotid Artery ◽  
Mononuclear Cells ◽  
Tendon Repair ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Calcaneal Tendon ◽  
Autologous Bone

Utilizou-se 15 coelhos adultos para avaliar o reparo de lesão do tendão calcanear comum com implante de artéria carótida de cães, preservada em glicerina, associado ou não a células mononucleares autólogas da medula óssea (CMAs). Os animais foram observados diariamente por meio de avaliações clínicas e o local do implante foi analisado sob microscopia de luz decorridos 15, 30 e 60 dias de pós-operatório. Notou-se em todos os períodos de observação, com o implante associado às CMAs, melhor desempenho físico dos membros pélvico e maior intensidade de fibras colágenas, fibroblastos e linfócitos e neovascularização. A utilização de xenoimplante de artéria carótida de cães preservada em glicerina associado à administração de células mononucleares da medula óssea foi eficiente no reparo do tendão calcanear comum de coelhos.

scholarly journals Autologous Bone Marrow Mononuclear Cells Enhance Recovery after Acute Ischemic Stroke in Young and Middle-Aged Rats

2009 ◽  
Vol 30 (1) ◽  
pp. 140-149 ◽  
Author(s):  
Miranda Brenneman ◽  
Sushil Sharma ◽  
Matthew Harting ◽  
Roger Strong ◽  
Charles S Cox ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Carotid Artery ◽  
Acute Ischemic Stroke ◽  
Mononuclear Cells ◽  
Infarct Volume ◽  
Autologous Bone Marrow ◽  
Needle Insertion ◽  
Bone Marrow Mononuclear Cells ◽  
Autologous Bone

We investigated intra-arterially administered autologous bone marrow mononuclear cells (MNCs) in rats with acute ischemic stroke. Long Evans rats (2 to 3 months or 12 months old) underwent tandem reversible common carotid artery (CCA)/middle cerebral artery (MCA) occlusion (CCAo/MCAo) for 3 h and then 24 h later underwent tibial bone marrow harvest. Ten million or 4 million cells were re-injected by an intra-carotid infusion. Control animals underwent marrow needle insertion and then saline injection into the carotid artery. Animals were assessed on a battery of neurological tests. MNCs in the ischemic brain were tracked using Q-dot nanocrystal labeling. Infarct volume and cytokines in the ischemia-affected brain were analyzed. Cell-treated animals in the younger and older groups showed improvement from 7 to 30 days after stroke compared with vehicle-treated animals. MNCs significantly reduced infarct volume compared with saline. There was a significant reduction in tumor necrosis factor-α, interleukin-1α (IL-1α), IL-β, IL-6, and a significant increase in IL-10 in injured brains harvested from the cell-treated groups compared with saline controls. Labeled MNCs were found in the peri-infarcted area at 1 h and exponentially decreased over the ensuing week after injection. Autologous bone marrow MNCs can be safely harvested from rodents after stroke, migrate to the peri-infarct area, enhance recovery, and modulate the post-ischemic inflammatory response.

Early Results of Core Decompression and Autologous Bone Marrow Mononuclear Cells Instillation in Femoral Head Osteonecrosis

2012 ◽  
Vol 27 (5) ◽  
pp. 679-686 ◽  
Author(s):  
Ramesh Kumar Sen ◽  
Sujit Kumar Tripathy ◽  
Sameer Aggarwal ◽  
Neelam Marwaha ◽  
Ratti Ram Sharma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Femoral Head ◽  
Mononuclear Cells ◽  
Core Decompression ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Femoral Head Osteonecrosis ◽  
Early Results ◽  
Autologous Bone

Intravenous autologous bone marrow mononuclear cells for ischemic stroke

2011 ◽  
Vol 70 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Sean I. Savitz ◽  
Vivek Misra ◽  
Mallik Kasam ◽  
Harrinder Juneja ◽  
Charles S. Cox ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Mononuclear Cells ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Autologous Bone
Sign in / Sign up

Export Citation Format

Share Document