scholarly journals Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology

2016 ◽  
Vol 94 (5) ◽  
pp. 298-306 ◽  
Author(s):  
Clement Hamani ◽  
Tipu Aziz ◽  
Bastiaan R. Bloem ◽  
Peter Brown ◽  
Stephan Chabardes ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Pedunculopontine Nucleus ◽  
Surgical Anatomy ◽  
Deep Brain

scholarly journals Efficacy and Safety of Pedunculopontine Nuclei (PPN) Deep Brain Stimulation in the Treatment of Gait Disorders: A Meta-Analysis of Clinical Studies

2015 ◽  
Vol 43 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Laleh Golestanirad ◽  
Behzad Elahi ◽  
Simon J. Graham ◽  
Sunit Das ◽  
Lawrence L. Wald
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Freezing Of Gait ◽  
Pedunculopontine Nucleus ◽  
Postural Instability ◽  
Internal Globus Pallidus ◽  
Motor Abnormalities ◽  
Deep Brain

AbstractBackground: Pedunculopontine nucleus (PPN) has complex reciprocal connections with basal ganglia, especially with internal globus pallidus and substantia nigra, and it has been postulated that PPN stimulation may improve gait instability and freezing of gait. In this meta-analysis, we will assess the evidence for PPN deep brain stimulation in treatment of gait and motor abnormalities especially focusing on Parkinson disease patients. Methods: PubMed and Scopus electronic databases were searched for related studies published before February 2014. Medline (1966-2014), Embase (1974-2010), CINAHL, Web of Science, Scopus bibliographic, and Google Scholar databases (1960-2014) were also searched for studies investigating effect of PPN deep brain stimulation in treatment of postural and postural instability and total of ten studies met the inclusion criteria for this analysis. Results: Our findings showed a significant improvement in postural instability (p<0.001) and motor symptoms of Parkinson disease on and off medications (p<0.05), but failed to show improvement in freezing of gait. Conclusions: Despite significant improvement in postural instability observed in included studies, evidence from current literature is not sufficient to generalize these findings to the majority of patients.

scholarly journals Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: MRI-Based Anatomoclinical Correlations and Optimal Target

Neurosurgery ◽  
2018 ◽  
Vol 84 (2) ◽  
pp. 506-518 ◽  
Author(s):  
Laurent Goetz ◽  
Manik Bhattacharjee ◽  
Murielle U Ferraye ◽  
Valérie Fraix ◽  
Carina Maineri ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Pedunculopontine Nucleus ◽  
Optimal Target ◽  
Deep Brain ◽  
Stimulation Of
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