Association between X-Ray Repair Cross-Complementing Group 1 Arg399Gln Polymorphism and Cervical Cancer Risk: A Meta-Analysis in the Chinese Population

2016 ◽  
Vol 82 (4) ◽  
pp. 382-387 ◽  
Author(s):  
Fang Zhang ◽  
Bing Li ◽  
Hong-Yan Wu ◽  
Li-Xin Shang
2013 ◽  
Vol 14 (11) ◽  
pp. 6703-6707 ◽  
Author(s):  
Ling-Yan Qin ◽  
Xu Chen ◽  
Ping Li ◽  
Zheng Yang ◽  
Wu-Ning Mo

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Lin Cheng ◽  
Yan Guo ◽  
Shipeng Zhan ◽  
Peiyuan Xia

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.


2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hua Jin ◽  
Xiaoyun Lu ◽  
Jing Ni ◽  
Jinfang Sun ◽  
Bin Gu ◽  
...  

2016 ◽  
Vol 16 (5) ◽  
pp. 662-667 ◽  
Author(s):  
Haiping Liu ◽  
Dan Lyu ◽  
Yan Zhang ◽  
Lianbing Sheng ◽  
Ning Tang

Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.


Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5137-5142 ◽  
Author(s):  
Jing Zhu ◽  
Lei Lu ◽  
Xiang Cheng ◽  
Rongkai Xie ◽  
Zhengqiong Chen ◽  
...  

2017 ◽  
Vol 11 (5) ◽  
pp. 459-471 ◽  
Author(s):  
Shujuan Yang ◽  
Chaoying Li ◽  
Xuejiao Li ◽  
Xiuling Huang ◽  
Qingge Zhao ◽  
...  

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