scholarly journals Primary Cerebellar Neuroendocrine Tumors: Chimeras or Real Entities A Case Report with a 6-Year Follow-Up

2016 ◽  
Vol 9 (2) ◽  
pp. 432-439
Author(s):  
Claudio Vernieri ◽  
Daniela Femia ◽  
Sara Pusceddu ◽  
Carlo Capella ◽  
Juan Rosai ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Clinical Behavior ◽  
First Report ◽  
Well Differentiated ◽  
The Moment ◽  
General Conditions

We report the case of a 38-year-old patient who was diagnosed with a cerebellar well-differentiated neuroendocrine tumor (WDNET) in 2009. At first glance, we believed that it was a metastasis from an unrecognized WDNET arising outside the cerebellum. However, despite a prolonged follow-up of 6 years, an extracranial WDNET has never been found. During this time, the tumor recurred locally twice, and the patient was treated with surgery and radiotherapy. At the moment, he enjoys good general conditions and his tumor is under control. Due to the histopathological characteristics and clinical behavior of the tumor, we believe that this is the first report to date of a primary cerebellar WDNET.

scholarly journals Comprehensive Treatment of Mediastinal Neuroendocrine Tumor: A Case Report

2021 ◽  
Author(s):  
Qi Yu ◽  
Zhen Li ◽  
Xinwei Han
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Neuroendocrine Tumors ◽  
Tumor Recurrence ◽  
Transcatheter Arterial Chemoembolization ◽  
Comprehensive Treatment ◽  
Drug Eluting ◽  
Arterial Chemoembolization

Abstract Neuroendocrine tumors in the mediastinum are relatively rare. We report a patient with mediastinal neuroendocrine tumor that was successfully resected after descending stage by drug-eluting embolic transcatheter arterial chemoembolization had been performed. No tumor recurrence was found in the 1-year follow-up after surgical resection.

scholarly journals Primary Neuroendocrine Tumor of the Testis Masquerading as Germ Cell Tumor – A Case Report

2020 ◽  
Vol 2 (6) ◽  
Author(s):  
Sulagna Manna ◽  
Suma Mysore Narayana ◽  
C. S. Premalata
Keyword(s):  
Case Report ◽  
Germ Cell ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Germ Cell Tumor ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Long Term Follow Up

Primary pure neuroendocrine tumors of the testis are rare with a high malignant potential requiring long-term follow-up. Only limited number of studies are available in the literature. In the present study, we describe a case report of a 31 year old young man who presented with a left testicular swelling, initially misdiagnosed as seminoma. Later, after correlating with the morphology and immunohistochemistry the diagnosis of neuroendocrine tumor of testis was concluded. Neuroendocrine tumors cases should be kept in long term follow up, to prevent relapse and recurrence.

scholarly journals FAS and Subsequent Therapies in Pancreatic Neuroendocrine Tumors

2021 ◽  
Author(s):  
Jane E. Rogers ◽  
Michael Lam ◽  
Daniel M. Halperin ◽  
Cecile G. Dagohoy ◽  
James C. Yao ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Cox Regression ◽  
Progression Free Survival ◽  
Pancreatic Neuroendocrine Tumors ◽  
Free Survival ◽  
Prior Therapy ◽  
Well Differentiated ◽  
Grade 3 ◽  
Line Of Therapy

We evaluated outcomes of treatment with 5-fluorouracil (5-FU), doxorubicin, and streptozocin (FAS) in well-differentiated pancreatic neuroendocrine tumors (PanNETs) and its impact on subsequent therapy (everolimus or temozolomide). Advanced PanNET patients treated at our center from 1992 to 2013 were retrospectively reviewed. Patients received bolus 5-FU (400 mg/m2), streptozocin (400 mg/m2) (both IV, days 1-5) and doxorubicin (40 mg/m2 IV, day 1) every 28 days. Overall response rate (ORR) was assessed using RECIST version 1.1. Of 243 eligible patients, 220 were evaluable for ORR, progression-free survival (PFS), and toxicity. Most (90%) had metastatic, nonfunctional PanNETs; 14% had prior therapy. ORR to FAS was 41% (95% confidence interval [CI]: 36-48%). Median follow-up was 61 months. Median PFS was 20 (95% CI: 15-23) months; median overall survival (OS) was 63 (95% CI: 60-71) months. Cox regression analyses suggested improvement with first-line vs subsequent lines of FAS therapy. Main adverse events ≥ grade 3 were neutropenia (10%) and nausea/vomiting (5.5%). Dose reductions were required in 32% of patients. Post-FAS everolimus (n=108; 68% second line) had a median PFS of 10 (95% CI: 8-14) months. Post-FAS temozolomide (n=60; 53% > fourth line) had an ORR of 13% and median PFS of 5.2 (95% CI: 4-12) months. In this largest reported cohort of PanNETs treated with chemotherapy, FAS demonstrated activity without significant safety concerns. FAS did not appear to affect subsequent PFS with everolimus; this sequence is being evaluated prospectively. Responses were noted with subsequent temozolomide-based regimens although PFS was possibly limited by line of therapy.

scholarly journals Hepatic pseudocystic metastasis of well-differentiated ileal neuroendocrine tumor: a case report with review of the literature

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Stefano Fiori ◽  
Alessandro Del Gobbo ◽  
Gabriella Gaudioso ◽  
Lucio Caccamo ◽  
Sara Massironi ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Review Of The Literature ◽  
Well Differentiated

A Well-Differentiated Liposarcoma in the Digit: A Case Report of the 5-Year Post-Surgical Follow-Up

2018 ◽  
Vol 23 (03) ◽  
pp. 415-418
Author(s):  
Sakiko Mizuno ◽  
Kensuke Ochi ◽  
Jun Miyauchi ◽  
Itsuo Watanabe ◽  
Hiraku Hotta ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Hand Function ◽  
Middle Finger ◽  
Imaging Findings ◽  
Lipomatous Tumor ◽  
Imaging Examination ◽  
Well Differentiated

A liposarcoma is extremely rare in the digits. A 73-year-old woman was diagnosed with a lipoma in her middle finger 10 years ago. As this tumor increased in size and presented with imaging findings that were atypical of lipomas, careful marginal resection biopsy outside the pseudo-capsule was performed, and the tumor was diagnosed as a well-differentiated liposarcoma. At the 5-year follow-up, the patient showed no evidence of local recurrence or metastasis, with no loss of hand function. The findings from this case suggest that even for a lipomatous tumor in the digits, further imaging examination and resection biopsy should be considered if the tumor presents with features that are atypical of lipomas.

Neuroendocrine tumor of the periappendicular area of the cecum bottom – a case report

2021 ◽  
Vol 75 (1) ◽  
pp. 68-71
Author(s):  
Lukáš Bača ◽  
Róbert Psár ◽  
Martin Hanousek ◽  
Petr Fojtík
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Enteroendocrine Cells ◽  
Special Group ◽  
Slow Growing

Neuroendocrine tumors are slow-growing neoplasms, histologically based on enteroendocrine cells. They are tumors with different degrees of differentiation, uncertain bio­logical nature and metastatic ability. Their most common localization is the gastrointestinal tract, with a special group of the neuroendocrine tumors of appendix, which are incidentally found after appendectomy. In case report, we would like to present a case of a patient with neuroendocrine tumors of appendix dia­gnosed by colonoscopy.

Imaging and Contrast-enhanced Ultrasound features of duodenal neuroendocrine tumor: A case report

2020 ◽  
Vol 76 (1) ◽  
pp. 27-32
Author(s):  
Yan-Qun Zhang ◽  
Jie-Xian Wen ◽  
Rong-Kui Luo ◽  
Hai-Xia Yuan ◽  
Wen-Ping Wang
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Endocrine Cells ◽  
Contrast Enhanced Ultrasound ◽  
Duodenal Neoplasms ◽  
Contrast Enhanced ◽  
Duodenal Neuroendocrine Tumors ◽  
Ultrasound Features

Duodenal neuroendocrine tumors are rare neoplasms arising from endocrine cells. Here we present a case of 32-year-old woman with Duodenal neuroendocrine tumors, report the imaging and contrast-enhanced Ultrasound (CEUS) features and review previous literatures of neuroendocrine tumors, which may be valuable for the differential diagnosis of duodenal neoplasms.

scholarly journals The Impact of Repeating Endosonography with Confocal Endomicroscopy for the Diagnosis of Cystic Neuroendocrine Tumor

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Iqra Haq ◽  
Somashekar G. Krishna ◽  
Bhaveshkumar Patel ◽  
Thavam Thambi-Pillai ◽  
Chencheng Xie ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Pancreatic Pseudocyst ◽  
Incidental Finding ◽  
Pancreatic Neuroendocrine Tumor ◽  
Needle Aspiration ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
The Impact

Cystic pancreatic neuroendocrine tumors represent around 13% of all neuroendocrine tumors (Hurtado-Pardo 2017). There has been an increase in the incidence of cases due to improvement in imaging modalities. This is a case of a 68-year-old male with the incidental finding of a pancreatic cyst on CT. Initial Endoscopic Ultrasound with Fine Needle Aspiration (EUS-FNA) showed sonographic and cytology features suggestive of a pancreatic pseudocyst. However the cyst persisted with no change in size after aspiration leading to a follow-up EUS- FNA, which was combined with needle based confocal laser endomicroscopy (nCLE). The nCLE features were consistent with a cystic pancreatic neuroendocrine tumor, which was later confirmed on histology after surgical resection.

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