Heterogeneity of Glucose Metabolism in Esophageal Cancer Measured by Fractal Analysis of Fluorodeoxyglucose Positron Emission Tomography Image: Correlation between Metabolic Heterogeneity and Survival

2016 ◽  
Vol 34 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Toru Tochigi ◽  
Kiyohiko Shuto ◽  
Tsuguaki Kono ◽  
Gaku Ohira ◽  
Takayuki Tohma ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Esophageal Cancer ◽  
Glucose Metabolism ◽  
Image Correlation ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Positron Emission ◽  
Tomography Image ◽  
Metabolic Heterogeneity ◽  
Fluorodeoxyglucose Positron Emission

Altered Regional Cerebral Glucose Metabolism in Internet Game Overusers: A 18F-fluorodeoxyglucose Positron Emission Tomography Study

CNS Spectrums ◽  
2010 ◽  
Vol 15 (3) ◽  
pp. 159-166 ◽  
Author(s):  
Hyun Soo Park ◽  
Sang Hee Kim ◽  
Seong Ae Bang ◽  
Eun Jin Yoon ◽  
Sang Soo Cho ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Impulse Control ◽  
Reward Processing ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Positron Emission ◽  
Regional Cerebral Glucose Metabolism ◽  
Fluorodeoxyglucose Positron Emission

ABSTRACTIntroduction: Internet game overuse is an emerging disorder and features diminished impulse control and poor reward-processing. In an attempt to understand the neurobiological bases of Internet game overuse, we investigated the differences in regional cerebral glucose metabolism at resting state between young individuals with Internet game overuse and those with normal use using 18F-fluorodeoxyglucose positron emission tomography study.Methods: Twenty right-handed male participants (9 normal users: 24.7±2.4 years of age, 11 overusers: 23.5±2.9 years of age) participated. A trait measure of impulsivity was also completed after scanning.Results: Internet game overusers showed greater impulsiveness than the normal users and there was a positive correlation between the severity of Internet game overuse and impulsiveness. Imaging data showed that the overusers had increased glucose metabolism in the right middle orbitofrontal gyrus, left caudate nucleus, and right insula, and decreased metabolism in the bilateral postcentral gyrus, left precentrai gyrus, and bilateral occipital regions compared to normal users.Conclusion: Internet game overuse may be associated with abnormal neurobiological mechanisms in the orbitofrontal cortex, striatum, and sensory regions, which are implicated in impulse control, reward processing, and somatic representation of previous experiences. Our results support the idea that Internet game overuse shares psychological and neural mechanisms with other types of impulse control disorders and substance/non-substance-related addiction.

Motor Cortex Stimulation Improves Local Cerebral Glucose Metabolism in the Ipsilateral Thalamus in Patients With Poststroke Pain: Case Report

Neurosurgery ◽  
2011 ◽  
Vol 69 (2) ◽  
pp. E462-E469 ◽  
Author(s):  
Masaki Ito ◽  
Satoshi Kuroda ◽  
Tohru Shiga ◽  
Nagara Tamaki ◽  
Yoshinobu Iwasaki
Keyword(s):  
Positron Emission Tomography ◽  
Glucose Metabolism ◽  
Motor Cortex ◽  
Cerebral Glucose Metabolism ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Motor Cortex Stimulation ◽  
18F Fluorodeoxyglucose ◽  
Positron Emission ◽  
Fluorodeoxyglucose Positron Emission

Abstract BACKGROUND AND IMPORTANCE: Motor cortex stimulation (MCS) is documented as an effective therapeutic option for patients with poststroke pain. However, its underlying mechanism is still unclear. This study aimed to evaluate local cerebral glucose metabolism before and after MCS in patients with poststroke pain. CLINICAL PRESENTATION: Using 18F-fluorodeoxyglucose positron emission tomography, cerebral metabolic rate for glucose (CMRGlu) was measured in 6 patients with poststroke pain before MCS. Their lesions were located in the corona radiata, internal capsule, and thalamus. An epidural electrode was implanted under the monitoring of intraoperative neuronavigation and somatosensory evoked/motor evoked potentials. 18F-fluorodeoxyglucose positron emission tomography was repeated in 4 patients (67%) who underwent successful MCS. Asymmetry of CMRGlu was semiquantitatively analyzed using an automated region of interest setting method. Before MCS, the ratio of CMRGlu in the ipsilateral to contralateral thalamus was 0.81 ± 0.13 (n = 6), (range, 0.63-0.97). However, there was no significant asymmetry of CMRGlu in other regions. Successful MCS significantly improved the asymmetry of CMRGlu in the ipsilateral thalamus from 0.81 ± 0.14 to 0.89 ± 0.17 (P < .01, n = 4). The therapeutic effect was proportional to the improvement of CMRGlu asymmetry (R = 0.79, P = 0.28; single regression analysis). CONCLUSION: Poststroke pain is closely related to the reduced glucose use in the thalamus contralateral to the painful area. Successful MCS significantly improves glucose use in the thalamus ipsilateral to MCS, suggesting that electrical stimulation of the motor cortex may activate the corticothalamic connection from the motor cortex.

scholarly journals Outcomes of Patients With Esophageal Cancer Staged With [18F]Fluorodeoxyglucose Positron Emission Tomography (FDG-PET): Can Postchemoradiotherapy FDG-PET Predict the Utility of Resection?

2010 ◽  
Vol 28 (31) ◽  
pp. 4714-4721 ◽  
Author(s):  
Arta Monir Monjazeb ◽  
Greg Riedlinger ◽  
Mebea Aklilu ◽  
Kim R. Geisinger ◽  
Girish Mishra ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Esophageal Cancer ◽  
Fdg Pet ◽  
Prospective Trial ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Trimodality Therapy ◽  
Positron Emission ◽  
Improved Outcomes ◽  
Fluorodeoxyglucose Positron Emission

Purpose To determine whether [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) can delineate patients with esophageal cancer who may not benefit from esophagectomy after chemoradiotherapy. Patients and Methods We reviewed records of 163 patients with histologically confirmed stage I to IVA esophageal cancer receiving chemoradiotherapy with or without resection with curative intent. All patients received surgical evaluation. Initial and postchemoradiotherapy FDG-PET scans and prognostic/treatment variables were analyzed. FDG-PET complete response (PET-CR) after chemoradiotherapy was defined as standardized uptake value ≤ 3. Results Eighty-eight patients received trimodality therapy and 75 received chemoradiotherapy. Surgery was deferred primarily due to medical inoperability or unresectable/metastatic disease after chemoradiotherapy. A total of 105 patients were evaluable for postchemoradiotherapy FDG-PET response. Thirty-one percent achieved a PET-CR. PET-CR predicted for improved outcomes for chemoradiotherapy (2-year overall survival, 71% v 11%, P < .01; 2-year freedom from local failure [LFF], 75% v 28%, P < .01), but not trimodality therapy. On multivariate analysis of patients treated with chemoradiotherapy, PET-CR is the strongest independent prognostic variable (survival hazard ratio [HR], 9.82, P < .01; LFF HR, 14.13, P < .01). PET-CR predicted for improved outcomes regardless of histology, although patients with adenocarcinoma achieved a PET-CR less often. Conclusion Patients treated with trimodality therapy found no benefit with PET-CR, likely because FDG-PET residual disease was resected. Definitive chemoradiotherapy patients achieving PET-CR had excellent outcomes equivalent to trimodality therapy despite poorer baseline characteristics. Patients who achieve a PET-CR may not benefit from added resection given their excellent outcomes without resection. These results should be validated in a prospective trial of FDG-PET–directed therapy for esophageal cancer.

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