scholarly journals Persistent Hypotony Associated with Immunosuppressive Therapy in Glaucoma Drainage Implant Surgery

2016 ◽  
Vol 7 (3) ◽  
pp. 410-415 ◽  
Author(s):  
Susana Duch ◽  
Elena Milla ◽  
Oana Stirbu ◽  
David Andreu

Purpose: To describe the histopathology of non-valved implant capsules in three cases of persistent postoperative hypotony after the restrictive tube ligature was released in patients receiving immunosuppressive therapy. Observations: The macroscopic appearance of the capsules 3 and 4 months postoperatively was immature and loose. Microscopic examination disclosed extremely irregular thin tissue, with thicknesses ranging from 0.02 to 0.6 mm, depending on the capsular location studied. Withdrawal of immunosuppressive therapy did not facilitate rebuilding of new capsules. Replacement with a valved implant device was necessary in two cases; the third case recovered with tapering of prednisone. Conclusions and Importance: The use of chronic systemic immunosuppressive therapy might interfere with capsular formation around the plates of drainage devices inducing persistent hypotony. In these cases, the use of valved implants might be safer.

Author(s):  
Gayathri Dinesh Kamath ◽  
Sunil Prabhakar Udgire ◽  
Divya Katewa

Aplastic anaemia with pregnancy is rarely encountered. Management of aplastic anaemia in pregnancy primarily involves a multidisciplinary approach offering supportive care. Our case was challenging as she developed aplastic anaemia during the third trimester and had refractory thrombocytopenia. She required platelet transfusions on a daily basis for few weeks as well as packed red blood cells frequently. Her leucocyte count was low initially but improved quickly unlike the platelet counts. Initiation of immunosuppressive therapy turned out to be beneficial and culminated in a good outcome. After starting immunosuppressive therapy with eltrombopag and cyclosporine she drifted through term and achieved a normal vaginal delivery.


2008 ◽  
Vol 132 (12) ◽  
pp. 1868-1873
Author(s):  
Joseph A. Tworek ◽  
David S. Wilkinson ◽  
Molly K. Walsh

Abstract Context.—The manual microscopic examination (MME) of the urine sediment is an imprecise and labor-intensive procedure. Many laboratories have developed rules from clinical parameters or urinalysis results to limit the number of these examinations. Objective.—To determine the rate of urinalysis specimens on which an MME of the urine sediment was performed, document how various rules influence this rate, and determine whether any new information was learned from the MME. Design.—Participants selected 10 random urinalysis tests received during each traditional shift and determined if an MME was performed until a total of 50 urinalysis tests with an MME were reviewed. Participants recorded the rules that elicited an MME and any new information learned from such an examination. Results.—The MME rate for the median institution was 62.5%. An MME of urine was most frequently done for an abnormal urinalysis result and often resulted in new information being learned, irrespective of the rule that elicited the MME. The median institution learned new information as a result of the manual examination 66% of the time. The use of an automated microscopic analyzer was associated with fewer manual examinations (P = .005), whereas the ability of a clinician to order a manual examination was associated with more manual examinations (P = .004). Conclusions.—The use of an automated microscopic analyzer may decrease the number of MMEs. An MME when triggered by an abnormal macroscopic appearance of urine, a physician request, or virtually any positive urinalysis result often resulted in new information.


2003 ◽  
Vol 51 (3) ◽  
pp. 321-329 ◽  
Author(s):  
A. Al-Samman ◽  
K. Molnár ◽  
Cs. Székely ◽  
J. Reiczigel

The weight of internal organs (swimbladder, kidney, liver, spleen) in relation to the body weight was studied in common carp fingerlings divided into three groups on the basis of swimbladder appearance and microscopic examination of the kidney. The fish had been collected from different Hungarian fish farms at the time when swimbladder inflammation (SBI) usually occurs (in July and August). The first group comprised fish with severe signs of SBI and massive renal sphaerosporosis, the second group consisted of fish with milder swimbladder changes and/or kidney infection by a low number of Sphaerospora renicola, while the third group was constituted by infection-free common carp fry. Statistical analysis of swimbladder, kidney, liver and spleen weight in relation to the body weight revealed that in the infected groups the internal organs were substantially enlarged. This suggests that in common carp fry with SBI the swimbladder changes are accompanied by reno-, hepato- and splenomegaly.


1971 ◽  
Vol 28 (4) ◽  
pp. 608-609 ◽  
Author(s):  
Daniel Hennick

Hermaphroditism in sea scallops is a relatively rare phenomenon. Observations on two hermaphroditic specimens of Placopecten magellanicus have been documented in the literature. Recent studies on the weathervane scallop, Patinopecten caurinus, in Alaska, have resulted in the discovery of a single hermaphroditic individual from sexual examination through dissection of more than 25,000 individuals over a 3-year study period. The specimen appeared to be a functional hermaphrodite, as both male and female follicules containing well-developed eggs and sperms were clearly evident from microscopic examination. Shell examination showed the animal had formed seven annual rings indicating the animal had spawned more than one season, since weathervane scallops mature after formation of the third annual ring.


1886 ◽  
Vol 40 (242-245) ◽  
pp. 10-14 ◽  

After referring to the literature of the subject, the author gives a short account of the macroscopic appearance of the brains of the following species of Plagiostomata, viz., Raja batis, Rhina squatina, Scyllium catulus , and Acanthias vulgaris . He then refers to the distribution of the cranial nerves, especially of the trifacial and vagus, pointing out the resemblance of the distribution of the last-mentioned nerve in Rhina to that described by Gegenbaur in Hexanthus; the difference lying in the fact that in the former the rami branchiales of this nerve, the number of which correspond the number of the branchial arches, divide into two terminal branches only, the rami anteriores and posteriores, the third, the rami pharyngei, being absent.


Neurosurgery ◽  
1990 ◽  
Vol 26 (1) ◽  
pp. 133-136 ◽  
Author(s):  
David J. Gower ◽  
Michael Pollay ◽  
Robert M. Shuman ◽  
Roger A. Brumback

Abstract A pilocytic astrocytoma of the optic nerve, chiasm, hypothalamus, or third ventricle is a relatively common tumor of childhood. This case report illustrates such a tumor, originating from this location, which is unusual because of the association with two very large cystic extensions into the middle cranial fossa and into the third ventricle. The massive size and extent of this tumor and cysts was demonstrated on a magnetic resonance imaging (MRI) scan, with gadolinium enhancement. This case illustrates a novel macroscopic appearance for a pilocytic glioma of the anterior third ventricle. The purpose of this report is to alert clinicians to the varied morphology this tumor may present as we apply increasingly our improved radiological, operative, and histopathological techniques. (Neurosurgery 26:133-137, 1990)


2009 ◽  
Vol 63 (1-2) ◽  
pp. 125-133
Author(s):  
Stanko Bozinovic ◽  
Darko Marinkovic

A dermoid is a malformation, a congenital choristoma, in fact an ectopic part of the skin. This malformation can be located on the eyelids (palpebral), on the palpebral or bulbar part of the conjunctive, on the third eyelid or on the cornea, the limbus edge of the eyelid. Ocular dermoids consist of a cornified squamous-stratified epithelium that can be pigmented to various degrees, located on irregular dermis in which there are hair follicles, sweat and fat glands, and, in rare cases, cartilage and bone can also be observed. Corneal dermoids can be classified into three types: limbal or epibulbar dermoid, a dermoid which covers the greater part or the entire cornea, a dermoid that covers the entire front segment of the eye. Coloboma presents a congenital malformation that is characterized by the absence of an eyelid and it can be located on the upper or on the lower lid. This paper presents the case of an English bulldog puppy in which a limbal dermoid and a palpebral coloboma-dermoid were observed at the same time. In this case, superficial keratectomy was selected for the treatment of the limbal dermoid, while the palpebral colobomadermoid was treated using excision with a plastic reconstruction procedure. A microscopic examination of sample tissue of the corneal demoid showed, on the surface, cornified squamous-stratified epithelium lying on the dermis. The dermis was observed to contain hair follicles, as well as sweat and fat glands.


Author(s):  
Grace Corrine Khong Yin Leong ◽  
Leesha Sharon ◽  
Pooja Pandey ◽  
Nadeem Guldar ◽  
Gopalkrishna K Bhat

  Objective: Rapid diagnosis of pulmonary tuberculosis (PTB) depends on microscopic examination of sputum smear for acid-fast bacilli (AFB). The direct microscopy examination lacks sensitivity. It needs at least 10,000 AFB/ml of sputum to observe in the smear. The objective of this study was to determine the efficacy of three different short-term bleach digestions and concentration of sputum in the diagnosis of PTB.Methods: A total of 171 sputum samples collected from patients suspected of having pulmonary TB were used. Direct smear was prepared using each sample and then divided into three parts to which equal volume of 5% bleach was added. The first part was kept at room temperature for 45 minutes with intermittent shaking. The second part was allowed to stand at room temperature for 45 minutes for sedimentation, and the third part was kept at room temperature for 45 minutes and then centrifuged at 3000 g for 15 minutes for deposit formation. Smears were prepared and stained with Ziehl-Neelsen method and observed for AFB using Revised National TB Control Programme Guidelines.Results: Out of 171 sputum samples, 45 (26.32%), 48 (28.07%), 49 (28.65%), and 55 (32.16%) of specimens were positive by direct, bleach digested mixed method, bleach digested sedimented method, and centrifugation method, respectively. The background of the bleach digested sputum smears was clear.Conclusion: Short-term bleach digestion of sputum improves the sensitivity of microscopic examination and the number of AFB observed in the smear. Bleach being a disinfectant kills AFB and makes handling of sputum safer.


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