Computer-Assisted Evaluation of Retinal Vessel Diameter in Retinitis Pigmentosa

2016 ◽  
Vol 56 (3) ◽  
pp. 139-144 ◽  
Author(s):  
Andrea Sodi ◽  
Dario Pasquale Mucciolo ◽  
Vittoria Murro ◽  
Claudia Zoppetti ◽  
Bianca Terzuoli ◽  
...  
2019 ◽  
pp. 112067211988698
Author(s):  
Andrea Sodi ◽  
Cristina Nicolosi ◽  
Giulio Vicini ◽  
Chiara Lenzetti ◽  
Gianni Virgili ◽  
...  

Purpose: Fabry disease retinal vascular involvement has been widely reported, with narrowing of the retinal arterioles, dilation and irregularity of the retinal veins, and exaggerated tortuosity of the retinal vessels. We evaluated retinal vessel diameter in Fabry disease, by means of a dedicated software, aiming to provide a quantitative marker of retinal vascular network abnormalities in Fabry disease patients. Material and methods: Observational case-control study evaluating different branches of vessels, peripapillary vessels (group A), temporal vascular arcades (group B), and second-order collaterals of the temporal arcades (group C). We obtained the vessel diameters values from eye fundus digital images of eight Fabry disease patients and eight age-sex matched controls, using a semiautomatic software. Mann–Whitney test was used to compare the Fabry disease group versus the control group. Results: The difference between the average diameters of all the types of vessels considered were significantly smaller in Fabry disease patients compared to healthy controls, resulting in a decrease in size (mm) of 10.9% for group A, 7.8% for group B, and 7.4% for group C. The most evident difference between Fabry disease patients and controls was found in the largest vessels. Conclusion: A computer-assisted analysis of retinal vessel diameter in Fabry disease by means of dedicated software showed narrower retinal arteries in Fabry disease patients than in controls. Our data support the use of semiautomatic assessment of retinal vessel attenuation as an objective and reproducible method to evaluate retinal vascular alterations in Fabry disease, providing a clinical non-invasive tool for early diagnosis and disease monitoring.


2015 ◽  
Vol 93 (7) ◽  
pp. e527-e533 ◽  
Author(s):  
Lisette T. Lopez Torres ◽  
Cengiz Türksever ◽  
Andreas Schötzau ◽  
Selim Orgül ◽  
Margarita G. Todorova

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Yong Un Shin ◽  
Sang Eon Lee ◽  
Heeyoon Cho ◽  
Min Ho Kang ◽  
Mincheol Seong

Purpose. This study sought to analyze peripapillary retinal vessel diameter and evaluate its correlation with retinal nerve fiber layer (RNFL) thickness in patients with unilateral normal-tension glaucoma (NTG). Methods. This retrospective study included 37 patients with unilateral NTG and 40 healthy controls. The unilateral NTG patients were selected based on RNFL photography and unilateral visual field (VF) defects from the Humphrey central 30-2 threshold test. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured and calculated using retinal photographs and a computer-assisted calculation program. The RNFL thickness was measured using spectral domain optical coherence tomography. Results. The mean CRAE and CRVE were significantly narrower in the glaucomatous and fellow eyes of the unilateral NTG patients than they were in the normal subjects (p<0.001). There was no significant correlation between CRAE/CRVE and RNFL thickness. There was only a significant correlation between VF severity and RNFL thickness in unilateral NTG eyes. Conclusions. Both NTG-affected eyes and NTG-fellow eyes in the unilateral NTG patients had narrower central retinal vessel diameters than did the eyes of normal subjects. Our results show that vascular factors may play a role in the NTG pathogenesis.


2006 ◽  
Vol 47 (9) ◽  
pp. 4026 ◽  
Author(s):  
Asan Kochkorov ◽  
Konstantin Gugleta ◽  
Claudia Zawinka ◽  
Robert Katamay ◽  
Josef Flammer ◽  
...  

2015 ◽  
Vol 56 (13) ◽  
pp. 7915 ◽  
Author(s):  
Eunjoo Yoo ◽  
Chungkwon Yoo ◽  
Bo-ram Lee ◽  
Tae-Eun Lee ◽  
Yong Yeon Kim

Author(s):  
Medine Gündoğan ◽  
Esra Vural ◽  
Nurettin Bayram ◽  
Orhan Altunel ◽  
Fatih Gündoğan ◽  
...  

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