scholarly journals Cystic Fibrosis Lung Immunity: The Role of the Macrophage

2016 ◽  
Vol 8 (6) ◽  
pp. 550-563 ◽  
Author(s):  
Emanuela M. Bruscia ◽  
Tracey L. Bonfield
Keyword(s):  
Cystic Fibrosis ◽  
Modifier Genes ◽  
Cystic Fibrosis Lung ◽  
Environmental Cues ◽  
Major Morbidity ◽  
Adaptive Immune ◽  
Lung Infections ◽  
Lung Immunity

Cystic fibrosis (CF) pathophysiology is hallmarked by excessive inflammation and the inability to efficiently resolve lung infections, contributing to major morbidity and eventually the mortality of patients with this disease. Macrophages (MΦs) are major players in lung homeostasis through their diverse contributions to both the innate and adaptive immune networks. The setting of MΦ function and activity in CF is multifaceted, encompassing the response to the unique environmental cues in the CF lung as well as the intrinsic changes resulting from CFTR dysfunction. The complexity is further enhanced with the identification of modifier genes, which modulate the CFTR contribution to disease, resulting in epigenetic and transcriptional shifts in MΦ phenotype. This review focuses on the contribution of MΦ to lung homeostasis, providing an overview of the diverse literature and various perspectives on the role of these immune guardians in CF.

scholarly journals Risk factors for respiratory Aspergillus fumigatus in German Cystic Fibrosis patients and impact on lung function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Uta Düesberg ◽  
Julia Wosniok ◽  
Lutz Naehrlich ◽  
Patience Eschenhagen ◽  
Carsten Schwarz
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Lung Function ◽  
Aspergillus Fumigatus ◽  
Age Groups ◽  
Antibiotic Use ◽  
Lower Lung ◽  
Lung Infections ◽  
The Impact

Abstract Airway inflammation and chronic lung infections in cystic fibrosis (CF) patients are mostly caused by bacteria, e.g. Pseudomonas aeruginosa (PA). The role of fungi in the CF lung is still not well elucidated, but evidence for a harmful and complex role is getting stronger. The most common filamentous fungus in CF is Aspergillus fumigatus (AF). Age and continuous antibiotic treatment have been discussed as risk factors for AF colonisation but did not differentiate between transient and persistent AF colonisation. Also, the impact of co-colonisation of PA and AF on lung function is still under investigation. Data from patients with CF registered in the German Cystic Fibrosis Registry database in 2016 and 2017 were retrospectively analysed, involving descriptive and multivariate analysis to assess risk factors for transient or persistent AF colonisation. Age represented an independent risk factor for persistent AF colonisation. Prevalence was low in children less than ten years, highest in the middle age and getting lower in higher age (≥ 50 years). Continuous antibiotic lung treatment was significantly associated with AF prevalence in all age groups. CF patients with chronic PA infection had a lower lung function (FEV1%predicted), which was not influenced by an additional AF colonisation. AF colonisation without chronic PA infection, however, was significantly associated with a lower function, too. Older age up to 49 years and continuous antibiotic use were found to be the main risk factors for AF permanent colonisation. AF might be associated with decrease of lung function if not disguised by chronic PA infection.

Modelling the bacterial communities associated with cystic fibrosis lung infections

2010 ◽  
Vol 29 (3) ◽  
pp. 319-328 ◽  
Author(s):  
T. Spasenovski ◽  
M. P. Carroll ◽  
A. K. Lilley ◽  
M. S. Payne ◽  
K. D. Bruce
Keyword(s):  
Cystic Fibrosis ◽  
Bacterial Communities ◽  
Cystic Fibrosis Lung ◽  
Lung Infections

scholarly journals Transmissible strains ofPseudomonas aeruginosain cystic fibrosis lung infections

2012 ◽  
Vol 40 (1) ◽  
pp. 227-238 ◽  
Author(s):  
Joanne L. Fothergill ◽  
Martin J. Walshaw ◽  
Craig Winstanley
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Lung ◽  
Lung Infections

scholarly journals Cystic Fibrosis Lung Infections: Polymicrobial, Complex, and Hard to Treat

2015 ◽  
Vol 11 (12) ◽  
pp. e1005258 ◽  
Author(s):  
Laura M. Filkins ◽  
George A. O’Toole
Keyword(s):  
Cystic Fibrosis ◽  
Cystic Fibrosis Lung ◽  
Lung Infections

scholarly journals Bacterial activity in cystic fibrosis lung infections

2005 ◽  
Vol 6 (1) ◽  
Author(s):  
Geraint B Rogers ◽  
Mary P Carroll ◽  
David J Serisier ◽  
Peter M Hockey ◽  
Valia Kehagia ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bacterial Activity ◽  
Cystic Fibrosis Lung ◽  
Lung Infections
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