scholarly journals Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

2016 ◽  
Vol 6 (2) ◽  
pp. 20-39 ◽  
Author(s):  
Colleen G. Le Prell ◽  
Angela Fulbright ◽  
Christopher Spankovich ◽  
Scott K. Griffiths ◽  
Edward Lobarinas ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Double Blind Study ◽  
Temporary Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Double Blind ◽  
Distortion Product ◽  
Significant Difference ◽  
Β Carotene

This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. Post-exposure TTS was measured, with no significant difference as a function of treatment. Distortion product otoacoustic emission amplitudes were suppressed after music exposure in both groups, with no significant difference as a function of treatment. Tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.

Electrocochleography is More Sensitive than Distortion-Product Otoacoustic Emission Test for Detecting Noise-Induced Temporary Threshold Shift

2005 ◽  
Vol 133 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Jin Sook Kim ◽  
Eui-Cheol Nam ◽  
Sung Il Park
Keyword(s):  
Sensitivity And Specificity ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Specific Information ◽  
Temporary Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Summating Potential ◽  
A Prospective Study

OBJECTIVE: We investigated and compared the usefulness of the electrocochleography and distortion product otoacoustic emission tests for detecting the earliest noise-induced damage by analyzing the sensitivity and specificity of the 2 tests. STUDY DESIGN: A prospective study. METHODS: After listening to music at 90.3 ± 4.2 dB in the same night-club for 2 hours continuously, 23 healthy normal ears experienced a temporary threshold shift exceeding 5 dB. Pure-tone audiometry, the distortion product otoacoustic emission test, and electrocochleography were performed before, immediately after, and 24 hours after the exposure. RESULTS: Before exposure, the measured distortion product/noise floor was 9.8 ± 10.4, 23.5 ± 6.4, 18.7 ± 6.4, and 19.1 ± 5.6 dB sound pressure level (SPL) at frequencies of 1, 2, 3, and 4 kHz, respectively. Immediately after exposure, it decreased significantly at 2, 3, and 4 kHz to 16.6 ± 7.6, 12.5 ± 6.8, and 14.8 ± 7.7 dB SPL, respectively. Marked increases in the amplitude of the summating potential and summating potential/action potential ratio were recorded from 0.15 ± 0.06 to 0.32 ± 0.11 and 0.23 ± 0.06 to 0.44 ± 0.08, respectively. The respective sensitivity and specificity of electrocochleography were 76.7% to 88.5% and 91.0% to 100%. Those of the distortion product otoacoustic emission test were 54.8% to 62.2% and 75.5% to 87.0%, respectively. CONCLUSION: Electrocochleography appears to provide more sensitive and specific information than the distortion product otoacoustic emission test for detecting a noise-induced temporary threshold shift.

Paradoxical long-term enhancement of distortion product otoacoustic emission amplitude after repeated exposure to moderate level, wide band noise in awake guinea pigs

2009 ◽  
Vol 123 (10) ◽  
pp. 1090-1096 ◽  
Author(s):  
L Mei ◽  
Z-W Huang ◽  
Z-Z Tao
Keyword(s):  
Guinea Pigs ◽  
Noise Exposure ◽  
Wide Band ◽  
Otoacoustic Emission ◽  
Threshold Shift ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Band Noise ◽  
Wide Band Noise

AbstractObjective:Hearing sensitivity usually diminishes with noise exposure. In the present study, we examined the effect of 93 dB(A) wide band noise on cochlear micromechanical sensitivity in awake guinea pigs.Methods:Animals were randomly assigned to groups receiving either single or repeated noise exposure. Distortion product otoacoustic emission amplitudes were recorded before, during and after noise exposure.Results:Ninety-three decibel(A) wide band noise reduced the distortion product otoacoustic emission amplitudes at all tested frequencies. The distortion product otoacoustic emission amplitudes for higher frequencies showed a permanent reduction, whereas those for lower frequencies showed a temporary reduction. Distortion product otoacoustic emission amplitudes for middle frequencies showed prolonged enhancement after repeated noise exposure.Conclusion:Our results suggest that (1) it is likely that there are intermediate stages between permanent threshold shift and temporary threshold shift, and (2) long-term enhancement of distortion product otoacoustic emission amplitudes may be an indication of tinnitus generation.

scholarly journals Effects of dexmedetomidine and esmolol on otoacoustic emissions during controlled hypotensive anesthesia: randomized clinical trial

2020 ◽  
Vol 43 (1) ◽  
pp. E9-E17
Author(s):  
Günhan Gökahmetoğlu ◽  
Sibel Pehlivan ◽  
Recep Aksu ◽  
Cihangir Biçer
Keyword(s):  
Frequency Band ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Sinus Surgery ◽  
Distortion Product Otoacoustic Emission ◽  
Controlled Hypotension ◽  
Double Blind ◽  
Distortion Product ◽  
Arterial Blood ◽  
Before And After

Purpose: The aim of this study was to investigate the ability of esmolol and dexmedetomidine to achieve controlled hypotension on cochlea by measuring otoacoustic emission and stapedius reflex. Methods: In this prospective, double-blind pilot study, patients scheduled for elective tympanoplasty, rhinoplasty and endoscopic sinus surgery operation were randomly assigned to two groups, and received either dexmedetomidine (n=23) or esmolol (n=24) during surgery to maintain a mean arterial blood pressure between 55 and 65 mmHg. Distortion product otoacoustic emission tests (DPOAE) were performed 24 hours before and after the operation and during surgery (in the 20th and 40th minutes of the operation). Results: In the intra-group comparison, a statistically significant decrease was present at t20 (2,000 and 4,000 Hz frequency band) and t40 (1,000 and 1,500 Hz) according to the baseline value in the dexmedetomidine group (n=23); in the esmolol group (n=24), a statistically significant decrease (relative to the baseline value) was also detected at t20 and t40 for the 1,000 Hz frequency band. No damage was found on stapes reflexes with the infusion of these drugs. Conclusions: Infusion of dexmedetomidine and esmolol decreased DPOAE levels during the operations, but DPOAE levels returned to normal in the postoperative period, and had no effect on stapes reflexes. Studies with larger groups of patients are needed to confirm these results in tympanoplasty and other surgeries.

scholarly journals Effect of Radiofrequency Waves of Mobile Phones on Distortion Product Otoacoustic Emissions

2021 ◽  
Author(s):  
Swetapadma Nayak ◽  
Rajeshwary Aroor ◽  
Usha Shastri ◽  
M. K. Goutham ◽  
Devika Sinha
Keyword(s):  
Mobile Phone ◽  
Mobile Phones ◽  
Otoacoustic Emissions ◽  
Prolonged Exposure ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Cochlear Hair Cells ◽  
Post Exposure ◽  
Distortion Product ◽  
Significant Difference

Abstract Objective The prolonged exposure to electromagnetic fields of mobile phones can damage the cochlear hair cells, which can be detected by otoacoustic emission (OAE). To know the effect of mobile phones on hearing, the young volunteers were subjected to prolonged mobile phone usage and changes in OAE were recorded. Materials and Methods Twenty-eight volunteers with normal hearing were made to talk one full hour continuously on the mobile phone. Distortion product otoacoustic emission (DPOAE) was measured prior to the usage of mobile phones and immediately after the use (post-exposure 1) and 24 hours after the use (post-exposure 2). The values were compared. Results Out of the 28 volunteers, 20 were females and 8 were males. Twenty-one volunteers preferred the right ear while using mobile phones, 7 preferred the left ear. There was no statistically significant difference between the baseline DPOAE values and values of post-exposure 1 and 2 when only the preferred ear was taken into consideration. When the preferred ear was compared with nonpreferred ear, a statistically significant difference was found only in the low frequencies between the pre-exposure and post-exposure 1 values. Conclusion This study shows there was no significant correlation between OAE and prolonged mobile phone exposure when the preferred ear was not considered.

scholarly journals Auditory fatigue among call center operators with headset

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Pretty Omar Afifi ◽  
Tayseer Taha Tayseer Abdel Rahman ◽  
Ahmed Gamal Khafagy
Keyword(s):  
Call Center ◽  
Absolute Threshold ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Contralateral Suppression ◽  
Significant Difference ◽  
Auditory Fatigue ◽  
Age Range

Abstract Background To assess whether call center operators are subject to or suffer from any auditory fatigue when compared to normal subjects. A prospective case-control study where twenty-eight call center operators (10 females and 18 males) with an age range from 25 to 46 years and twenty controls (12 females and 8 males) with an age range from 23 to 44 years were included. All call center operators use a headset for up to 8 h daily for a minimum of two consecutive years. Audiological assessments were done to all participants that included pure tone audiometry (PTA), speech audiometry, tympanometry, and acoustic reflexes. Moreover, transient-evoked otoacoustic emission (TEOAE) absolute threshold and distortion product otoacoustic emission (DPOAE) signal to noise thresholds as well as contralateral suppression of TEOAEs and DPOAEs were recorded for both groups. Results There was no significant variation in auditory performances detected with either PTA or OAE (TEOAEs and DPOAEs) test. Besides, there was no statistically significant difference in OAEs (TEOAEs and DPOAEs) with contralateral suppression for both the call center operators and control groups. However, call center operators expressed a feeling of tiredness. Conclusions There was no detectable central or peripheral auditory fatigue experienced by the call center operators when using headsets. However, their sensation of auditory fatigue could be due to cognitive fatigue rather than noise-induced fatigue.

scholarly journals Distortion-product otoacoustic emission growth curves in neonates

2014 ◽  
Vol 60 (6) ◽  
pp. 591-598
Author(s):  
Tania Alves Barbosa ◽  
Alessandra Spada Durante ◽  
Lidio Granato
Keyword(s):  
Otoacoustic Emissions ◽  
Growth Curves ◽  
Otoacoustic Emission ◽  
Acoustic Energy ◽  
Risk Indicators ◽  
Distortion Product Otoacoustic Emission ◽  
Distortion Product ◽  
Significant Difference ◽  
Emission Growth ◽  
To Receive

Background: The recording of otoacoustic emissions (OAE) enabled us to prove that the cochlea is able not only to receive sounds but also to produce acoustic energy. Through the use of distortion-product otoacoustic emission measurements, the growth of the response was seen according to the intensity of the sound stimulus presented (growth curve). Objective: to determine the thresholds for the emergence of distortion-product otoacoustic emissions (DPOAE) on frequencies of 2000 and 4000 Hz with a stimulus varying from 20 to 65dB SPL, and to establish the slope values obtained in the growth curves. Methods: 39 neonates aged 5 to 28 days without risk indicators of hearing loss were studied. The DPOAE growth curves were obtained on the frequencies from 2000 Hz and 4000 Hz with a level of intensity ranging from 20 to 65dB SPL divided into two paradigms (20 to 40dB SPL and 40-65dB SPL). Results: there was a statistically significant difference in the thresholds for the emergence of DPOAE depending on the criteria used. The thresholds were on average higher at 4000 Hz than 2000 Hz and the slope was higher on average at 2000 Hz than 4000 Hz, although not statistically significant in either case. Conclusion: the thresholds were on average 30dB SPL at 2000Hz and 35dB SPL at 4000Hz. The slope values varied between 3 and 4 on average, reaching 15 in some cases.

Pengaruh sisplatin dosis tinggi terhadap penurunan fungsi sel rambut luar koklea

2013 ◽  
Vol 40 (2) ◽  
Author(s):  
Asti Kristianti ◽  
Teti Madiadipoera ◽  
Bogi Soeseno
Keyword(s):  
Hair Cells ◽  
Malignant Neoplasm ◽  
Otoacoustic Emission ◽  
Outer Hair Cells ◽  
High Dose ◽  
Distortion Product Otoacoustic Emission ◽  
Inclusion Criteria ◽  
Cochlear Hair Cells ◽  
Distortion Product ◽  
Bilateral Sensorineural Hearing Loss

Background: Chemotherapy is worldwide used nowadays, and its toxicity still remain a problemespecially toxicity to the ear (ototoxicity). Cisplatin (cis-diamminedichloroplatinum) is one of themost commonly used chemotherapy and highly potent in treating epithelial malignancies. Ototoxicitycaused by cisplatin is irreversible, progressive, bilateral, sensorineural hearing loss especially on highfrequency (4-8 KHz) accompanied by tinnitus. Purpose: To observe the cochlear outer hair cells damagein malignancies patients treated with cisplatin. Methods: This study is an observational analytic studywith prospective design to determine the influence of high dose cisplatin on cochlear outer hair cellsfunction. The research was carried out at the ENT-HNS Department, Hasan Sadikin General HospitalBandung, from November 2007 until June 2008. Audiometry, tympanometry, and distortion productotoacoustic emission (DPOAE) examinations were conducted before chemotherapy and DPOAE, andtimpanometry was again measured three days after first and second cycles of cisplatin administration. McNemar test was performed to calculate the effects of high-dose cisplatin to the cochlear outer haircells function. To compare pre and post-cisplatin on alteration of cochlear hair cells function, Wilcoxontest was used. Results: In this study 60 ears from 30 subjects that meet the inclusion criteria, consistedof 25 man (83.3%) and 5 women (16.7%). The prevalence of damaged cochlear outer hair cells were63% at first cycle and 70% at second cycle of cisplatin administration. The decline of cochlear outerhair cells function was significant (p<0.001). Conclusion: High-dose cisplatin decreases cochlear outerhair cells function in patients with malignant neoplasm. Abstrak : Latar belakang: Kemoterapi sekarang rutin digunakan secara klinis di seluruh dunia. Sejalan denganhal tersebut toksisitas kemoterapi, khususnya terhadap telinga saat ini menjadi perhatian. Sisplatin(cis-diamminedichloroplatinum) adalah salah satu obat kemoterapi yang paling banyak digunakandan paling manjur untuk terapi keganasan epitelial. Efek ototoksik sisplatin yaitu terjadi gangguandengar sensorineural yang irreversible, progresif, bilateral pada frekuensi tinggi (4-8 kHz), dan disertaidengan tinitus. Tujuan: Untuk menilai penurunan fungsi sel rambut luar koklea pada penderita tumorganas sesudah pemberian sisplatin dosis tinggi dengan menggunakan DPOAE. Metode: Studi analitikobservasional dengan rancangan prospektif di Bagian IK. THT-KL RS. Hasan Sadikin Bandung mulaibulan November 2007 sampai dengan Juni 2008. Pada penelitian ini dilakukan pemeriksaan audiometrinada murni, timpanometri, dan distortion product otoacoustic emission (DPOAE) prakemoterapi, kemudianDPOAE dan timpanometri diulang tiga hari sesudah siklus pertama dan kedua kemoterapi sisplatin. Datayang diperoleh diuji dengan uji McNemar dan uji Wilcoxon. Hasil: Dari penelitian didapat 60 telingadari 30 subjek penelitian yang memenuhi kriteria inklusi yang terdiri dari 25 laki-laki (83,3%) dan 5perempuan (16,7%). Insidens penurunan fungsi sel rambut luar koklea sebesar 63% (38 kasus) sesudahsiklus pertama dan 70% (42 kasus) sesudah siklus kedua. Hubungan penurunan fungsi sel rambut luarkoklea memberikan nilai yang sangat bermakna sejak pemberian siklus pertama (p<0,001). Kesimpulan:Pemberian sisplatin dosis tinggi pada penderita tumor ganas menyebabkan penurunan fungsi sel rambutluar koklea.Kata kunci: kemoterapi, sisplatin dosis tinggi, sel rambut luar koklea.

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